Cardiotonic and antidysrhythmic effects of oleanolic and ursolic acids, methyl maslinate and uvaol

Cardioprotective Effect of Oleanolic Acid on Isoproterenol-Induced Myocardial Ischemia in Rats

“…Oleanolic acid (OA) (Figure 1) is a triterpenoid compound that exists widely in food and herbs (Liu, 1995). It has a variety of biological effects, such as anti-oxidants (Balanehru andNagarajan, 1991), antifungal, anti-inflammatory, anti-hyperlipdemia, hepatoprotective, tumor prevention, immunomodulatory, (Price et al, 1987;Nishino et al, 1988), anti-HIV (Kashiwada et al, 2000), anti-arrhythmic and cardiotonic (Somova et al, 2004). OA has been used successfully to treat liver disease in humans (Hunan Medical Institute, 1997).…”

Antimicrobial Activity of Oleanolic Acid for Foodborne Bacteria

“…, 특히 정향 잎(Syzygium aromaticum; 1.65 g/100 g 건조중량) 24) , 올리브 잎(Olea europaea; 3.1 g/100 g 건조중량) [25][26][27] , 로즈마리 잎(Rosmarinus officinalis; 1.23/100 g 건조중량) [28][29][30] 등에서 추출 된다. .…”

Use of solid residue from the olive industry

“…Numerous studies have been published on the possible biological activity of this acid and its glucosides. It has been studied in its activity as an inhibitor of the proliferation of leucemic cells (Es-Saady et al, 1994), as a hypoglucemiant (Yoshikawa et al, 1994), as an anti-tumoral agent (Gerhauser et al, 2003), as a hepatoprotective agent (Yim et al, 2001), as an anti-inflammatory (Ismaili et al, 2002;Takeoka et al, 2000 andChoi et al, 2002), as an anti-bacterial (Sasazuka et al, 1995), as an inhibitor of the production of nitric acid (Honda et al, 1997), as an anti-HIV agent (Mengoni et al, 2002), in its anti-atherogenic activity (Somova et al, 2003) and as a cardiotonic (Somova et al, 2004). Also in existence are publications and patents for the preparation of functional foods with oleanolic acid (Hassel et al, 1998;Putte, 2000;Guinda et al, 2004).…”