Cardiovascular Autonomic Dysfunction and Falls in People With Multiple Sclerosis: Is There a Link? An Opinion Article

Zanotto, Tobia; Hernandez, Manuel E.; Medrano, Cristina N; Wilund, Kenneth R.; Sosnoff, Jacob J.

doi:10.3389/fnins.2020.610917

Cited by 2 publications

(2 citation statements)

References 62 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Numerous studies have outlined a relationship between fatigue and autonomic dysfunction in people with MS. 59 It was found that cardiac autonomic dysfunction in MS patients could result in fatigue-related processes and result in falls. 60 A study observed that patients with MS displayed lower blood pressure response, compared to that fatigue-free. 60 Fatigue and impaired upright postural balance are the hallmarks of MS, which all increases risk of MS-related falls.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Exploring Factors Associated with Falls in Multiple Sclerosis: Insights from a Scoping Review

Kaddoura,

Faraji,

Othman

et al. 2024

CIA

View full text Add to dashboard Cite

Multiple sclerosis (MS) is a chronic inflammatory condition that causes demyelination of the central nervous system accompanied by a wide range of symptoms. The high prevalence of falls among patients diagnosed with MS within the initial six months highlights the importance of this issue. The objective of this study is to identify factors associated with falls in MS patients in order to increase awareness and reduce the risk of falls. This scoping review used specific Mesh terms to formulate the literature search around falls and MS using Medline, Google Scholar, Scopus, and Embase search engines. English papers published between 2012 and 2022, studies with a clear definition of falls, McDonald's diagnostic criteria for MS, and those with Expanded Disability Status Scale (EDSS) or Patient Determined Disease Steps (PDDS) scores were included. Critical data from the selected articles were extracted and classified according to the different factors associated with falls in MS patients. Eighteen articles were included in this review. The most important factors associated with falls in MS patients identified were the severity and progression of the disease, mobility and balance problems, bladder dysfunction, fear of falling, fatigue, and cognitive dysfunction. In conclusion, this scoping review yielded the most common factors associated with falls in patients with MS. Study findings can be used to develop future interventions focusing on improving mobility, proprioception, and balance to decrease fall risk and injury amongst MS patients.

show abstract

Section: Discussionmentioning

confidence: 99%

“… 60 A study observed that patients with MS displayed lower blood pressure response, compared to that fatigue-free. 60 Fatigue and impaired upright postural balance are the hallmarks of MS, which all increases risk of MS-related falls. 61 …”

Section: Discussionmentioning

confidence: 99%