Cardiovascular autonomic dysfunction in Parkinson's disease

Ziemssen, Tjalf; Reichmann, Heinz

doi:10.1016/j.jns.2009.08.031

Cited by 134 publications

(92 citation statements)

References 60 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A decline in HRV has also been shown to be an independent predictor of fatal arrhythmic events and sudden death due to congestive heart failure (Fauchier et al 1999). Several reports have shown ANS dysfunction among patients with diabetes mellitus (Lindmark et al 2003), hypertension (Mussalo et al 2001), multiple system atrophy (Kitae et al 2001), and Parkinson disease (Ziemssen and Reichmann 2010). Additionally, the prevalence of sleep-disordered breathing may increase with age to a prevalence of approximately 20% in older patients relative to 5% to 10% in younger populations in The Sleep Heart Health Study (Young et al 2002).…”

Section: Discussionmentioning

confidence: 99%

Consciously Controlled Breathing Decreases the High-Frequency Component of Heart Rate Variability by Inhibiting Cardiac Parasympathetic Nerve Activity

Sasaki

Maruyama

2014

Tohoku J. Exp. Med.

View full text Add to dashboard Cite

Heart rate variability (HRV), the beat-to-beat alterations in heart rate, comprises sympathetic and parasympathetic nerve activities of the heart. HRV analysis is used to quantify cardiac autonomic regulation. Since respiration could be a confounding factor in HRV evaluation, some studies recommend consciously controlled breathing to standardize the method. However, it remains unclear whether controlled breathing affects HRV measurement. We compared the effects of controlled breathing on HRV with those of spontaneous breathing. In 20 healthy volunteers, we measured respiratory frequency (f), tidal volume, and blood pressure (BP) and recorded electrocardiograms during spontaneous breathing (14.8 ± 0.7 breaths/min) and controlled breathing at 15 (0.25 Hz) and 6 (0.10 Hz) breaths/min. Compared to spontaneous breathing, controlled breathing at 0.25 Hz showed a higher heart rate and a lower highfrequency (HF) component, an index of parasympathetic nerve activity, although the f was the same. During controlled breathing at 0.10 Hz, the ratio of the low frequency (LF) to HF components (LF/HF), an index of sympathetic nerve activity, increased greatly and HF decreased, while heart rate and BP remained almost unchanged. Thus, controlled breathing at 0.25 Hz, which requires mental concentration, might inhibit parasympathetic nerve activity. During controlled breathing at 0.10 Hz, LF/HF increases because some HF subcomponents are synchronized with f and probably move into the LF band. This increment leads to misinterpretation of the true autonomic nervous regulation. We recommend that the respiratory pattern of participants should be evaluated before spectral HRV analysis to correctly understand changes in autonomic nervous regulation.

show abstract

Section: Discussionmentioning

confidence: 99%

Consciously Controlled Breathing Decreases the High-Frequency Component of Heart Rate Variability by Inhibiting Cardiac Parasympathetic Nerve Activity

Sasaki

Maruyama

2014

Tohoku J. Exp. Med.

View full text Add to dashboard Cite

show abstract

“…23 Disturbed sympathetic nerve traffic [24][25][26] and depressed arterial BRS 27 underlie the increased cardiovascular mortality reported in association with the condition. 28 Stimulation of the STN improves the skeletal motor dysfunction in these patients 29 and alters cardiovascular parameters.…”

Section: Msna and Brs In Stn Targetsmentioning

confidence: 99%

Differentiated Baroreflex Modulation of Sympathetic Nerve Activity During Deep Brain Stimulation in Humans

et al. 2014

View full text Add to dashboard Cite

Targeted electric deep brain stimulation in midbrain nuclei in humans alters cardiovascular parameters, presumably by modulating autonomic and baroreflex function. Baroreflex modulation of sympathetic outflow is crucial for cardiovascular regulation and is hypothesized to occur at 2 distinct brain locations. The aim of this study was to evaluate sympathetic outflow in humans with deep brain stimulating electrodes during ON and OFF stimulation of specific midbrain nuclei known to regulate cardiovascular function. Multiunit muscle sympathetic nerve activity was recorded in 17 patients undergoing deep brain stimulation for treatment of chronic neuropathic pain (n=7) and Parkinson disease (n=10). Sympathetic outflow was recorded during ON and OFF stimulation. Arterial blood pressure, heart rate, and respiratory frequency were monitored during the recording session, and spontaneous vasomotor and cardiac baroreflex sensitivity were assessed. Head-up tilt testing was performed separately in the patients with Parkinson disease postoperatively. Stimulation of the dorsal most part of the subthalamic nucleus and ventrolateral periaqueductal gray resulted in improved vasomotor baroreflex sensitivity, decreased burst frequency and blood pressure, unchanged burst amplitude distribution, and a reduced fall in blood pressure after tilt. Stimulation of the dorsolateral periaqueductal gray resulted in a shift in burst amplitude distribution toward larger amplitudes, decreased spontaneous beat-to-beat blood pressure variability, and unchanged burst frequency, baroreflex sensitivity, and blood pressure. Our results indicate that a differentiated regulation of sympathetic outflow occurs in the subthalamic nucleus and periaqueductal gray. These results may have implications in our understanding of abnormal sympathetic discharge in cardiovascular disease and provide an opportunity for therapeutic targeting.

show abstract

“…Durante la RC los sujetos sanos presentaron valores significativamente mayores en LF en comparación con los sujetos con EP. Post-CP se encontró un aumento significativo de ambos índices, LFPTT y HFPTT , en los pacientes con EP con respecto a los sujetos sanos, este resultado soporta el comportamiento de los índices obtenidos con la señal de intervalos RR y sugiere una alteración en la respuesta del SNA por parte de los pacientes con EP, coincidiendo con resultados previos [6,17] . Además, se observó una diferencia significativa entre sanos y pacientes con EP en Post-Hip.…”

Section: Resultados Y Discusiónunclassified

Assessment of the Dysautonomia Presence in Parkinson disease through Cardiovascular Signal Analysis

Jalomo

Álvarez

Dorantes-Méndez

2017

Rev. Mex. Ing. Biomed.

View full text Add to dashboard Cite

RESUMENEn este trabajo se evalúa y compara la respuesta del sistema nervioso autónomo (SNA) en pacientes con enfermedad de Parkinson (EP) y sujetos sanos para detectar la posible presencia de disautonomía. Las señales de electrocardiograma y fotopletismografía fueron adquiridas durante las maniobras: reposo, cambio de postura (Post-CP), respiración controlada (RC) e hiperventilación (Hip.). El análisis de las señales incluyó índices de la variabilidad de la frecuencia cardiaca (VFC) lineales y no lineales, índices de la señal de tiempo de tránsito de pulso y la sensibilidad del barorreflejo (índice α). Los pacientes con Parkinson mostraron una alteración en la modulación simpática principalmente durante Post-CP y una deficiencia en la respuesta cardiovagal en RC. La entropía aproximada disminuyó significativamente en sujetos sanos respecto a pacientes con EP durante RC. El índice α fue menor en pacientes con EP con respecto a sujetos sanos durante todo el protocolo, lo cual sugiere una alteración en el control del barorreflejo en EP. Sin embargo, es necesario aumentar el número de sujetos con la finalidad de determinar grados de disautonomía. El protocolo diseñado para evaluar la presencia de disautonomía en mexicanos con EP a través de señales no invasivas aportó información sobre el comportamiento del SNA.

show abstract

Cardiovascular autonomic dysfunction in Parkinson's disease

Cited by 134 publications

References 60 publications

Consciously Controlled Breathing Decreases the High-Frequency Component of Heart Rate Variability by Inhibiting Cardiac Parasympathetic Nerve Activity

Consciously Controlled Breathing Decreases the High-Frequency Component of Heart Rate Variability by Inhibiting Cardiac Parasympathetic Nerve Activity

Differentiated Baroreflex Modulation of Sympathetic Nerve Activity During Deep Brain Stimulation in Humans

Assessment of the Dysautonomia Presence in Parkinson disease through Cardiovascular Signal Analysis

Contact Info

Product

Resources

About