Cardiovascular Disease Prevention and Therapy in Women With Type 2 Diabetes

Cocchi, Camilla; Coppi, Francesca; Farinetti, Alberto; Mattioli, Anna Vittoria

doi:10.2217/fca-2021-0011

Cited by 18 publications

(12 citation statements)

References 78 publications

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“…Studies in mouse models have also shown the involvement of Lonp1 in atherosclerosis [ 69 ], and its oxidative inactivation after transaortic constriction (TAC) in mouse heart [ 70 ]. Atherosclerosis is a chronic inflammatory and metabolic disease and a major risk factor for myocardial infarction [ 71 , 72 ]. During atherosclerosis, Lonp1 is upregulated in macrophages by saturated fatty acids and by PERK-eIF2α activated signaling.…”

Section: The Role Of Lonp1 In Heart Homeostasis and Response To Stressmentioning

confidence: 99%

The Role of Lonp1 on Mitochondrial Functions during Cardiovascular and Muscular Diseases

et al. 2023

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The mitochondrial protease Lonp1 is a multifunctional enzyme that regulates crucial mitochondrial functions, including the degradation of oxidized proteins, folding of imported proteins and maintenance the correct number of copies of mitochondrial DNA. A series of recent studies has put Lonp1 at the center of the stage in the homeostasis of cardiomyocytes and muscle skeletal cells. During heart development, Lonp1 allows the metabolic shift from anaerobic glycolysis to mitochondrial oxidative phosphorylation. Knock out of Lonp1 arrests heart development and determines cardiomyocyte apoptosis. In adults, Lonp1 acts as a cardioprotective protein, as its upregulation mitigates cardiac injury by preventing the oxidative damage of proteins and lipids, and by preserving mitochondrial redox balance. In skeletal muscle, Lonp1 is crucial for cell development, as it mediates the activation of PINK1/Parkin pathway needed for proper myoblast differentiation. Skeletal muscle-specific ablation of Lonp1 in mice causes reduced muscle fiber size and strength due to the accumulation of mitochondrial-retained protein in muscle. Lonp1 expression and activity decline with age in different tissues, including skeletal muscle, and are associated with a functional decline and structural impairment of muscle fibers. Aerobic exercise increases unfolded protein response markers including Lonp1 in the skeletal muscle of aged animals and is associated with muscle functional recovery. Finally, mutations of Lonp1 cause a syndrome named CODAS (Cerebral, Ocular, Dental, Auricular, and Skeletal anomalies) characterized by the impaired development of multiple organs and tissues, including myocytes. CODAS patients show hypotonia and ptosis, indicative of skeletal muscle reduced performance. Overall, this body of observations points Lonp1 as a crucial regulator of mitochondrial functions in the heart and in skeletal muscle.

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Section: The Role Of Lonp1 In Heart Homeostasis and Response To Stressmentioning

confidence: 99%

The Role of Lonp1 on Mitochondrial Functions during Cardiovascular and Muscular Diseases

et al. 2023

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“…22 The physiology of subcutaneous and visceral adipose in women is different compared to men, with over 2800 genes differentially expressed. 23 Men have larger fat cell sizes in the intra-abdominal compartment, whereas women have larger fat cell sizes in subcutaneous depots. 24 These sex differences in adiposity distribution influence the flux of fatty acids that occurs in fasting and feeding.…”

Section: Obesity and Womenmentioning

confidence: 99%

Long COVID: A New Challenge for Prevention of Obesity in Women

Mattioli

Nasi

Gallina

2022

American Journal of Lifestyle Medicine

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The long COVID affects individuals that do not recover for several weeks or months following the onset of symptoms of COVID-19. Obesity could play a role in the long COVID syndrome. During the pandemic, various factors contributed greatly to aggravating obesity in women leading to a pro-inflammatory and prothrombotic status. The present commentary explores the relationship between long COVID and obesity in women.

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“…The gap in the diagnosis and treatment of cardiovascular disease in women depends on several factors: the lack of self-perception of cardiovascular risk, the exposure to risk factors that act with a difference in women and men, and specific sex-related risk factors, which are still little known. 41 …”

Section: Primary Prevention Of Cardiovascular Diseasementioning

confidence: 99%

“…40 The gap in the diagnosis and treatment of cardiovascular disease in women depends on several factors: the lack of self-perception of cardiovascular risk, the exposure to risk factors that act with a difference in women and men, and specific sex-related risk factors, which are still little known. 41 Sexual dimorphism in fat distribution and metabolism of adipose tissue and skeletal muscle affects sex differences in tissue-specific insulin sensitivity and cardiometabolic health. Additionally, sex hormones, such as estrogen and testosterone, as well as the complement of sex chromosomes, are likely to play a role in sex differences in cardiovascular disease.…”

mentioning

confidence: 99%

Subclinical Vascular Damage: Current Insights and Future Potential

Mattioli¹,

Coppi²,

Manenti³

et al. 2021

VHRM

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The cardiovascular risk assessment must be carried out during all the different phases of life because the cardiovascular risk and the related prevention actions are dynamic and constantly evolving. As patients age, they change their exposure to various risk factors and accumulate comorbidities by changing their subjective cardiovascular risk, so it is necessary to undertake personalized early and preventive diagnostic actions. The main approach to asymptomatic vascular disease is based on primary prevention with the adoption of a healthy lifestyle. Indeed, lifestyle influences most of the traditional risk factors. In recent years, important differences between the sexes regarding cardiovascular risk factors have emerged and in particular, risk factors specific for female sex have been identified. Women are more likely to be categorized into lower risk categories for cardiovascular disease and, as a result, receive less lifestyle counseling than men, as well as less intensive prevention. This narrative review aims to analyze CVD risk prevention in asymptomatic atherosclerosis with a look at new emerging factors. In the end, we quickly analyzed the effects of the recent pandemic on lifestyle and cardiovascular risk and the potential negative effects in the long term.

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Cardiovascular Disease Prevention and Therapy in Women With Type 2 Diabetes

Cited by 18 publications

References 78 publications

The Role of Lonp1 on Mitochondrial Functions during Cardiovascular and Muscular Diseases

The Role of Lonp1 on Mitochondrial Functions during Cardiovascular and Muscular Diseases

Long COVID: A New Challenge for Prevention of Obesity in Women

Subclinical Vascular Damage: Current Insights and Future Potential

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