Cardiovascular effects of midazolam and thiopentone for induction of anaesthesia in Ill surgical patients

Abstract

The cardiovascular effects of mldazolam (0.15 mg kg -t ) and

Evaluation of blood pressure in feline night monkeys (Aotus azarae infulatus) under different restraint protocols

“…Although midazolam is to be considered among the benzodiazepines, which further reduce blood pressure [12,20], this was not observed in the KET group. However, pressure reduction occurred with the use of isoflurane, confirming literature reports [6,16], and with findings by Vasconcellos et al [26] in Cebus apella.…”

Respiratory and cardiovascular effects in relation to plasma levels of midazolam and diazepam.

“…Both midazolam and diazepam transiently depress the baroreflex function and decrease the sympathetic tone (Marty et al, 1986a). The reduction in MAP after midazolam induction in both healthy (Marty et al, 1986a;Lebowitz et al,1982) and ill patients (Marty et al, 1986b;Lebowitz et al, 1983) is reported to be 15-19% when measuring the blood pressure invasively, despite doses ranging from 0.15 to 0.30 mg kg'-1. This supports our findings of a maximal effect on blood pressure evoked by midazolam at lower, sedative doses with a maximum decrease on MAP of 18%.…”

The effect of a pre‐operative infusion of Ringer's solution on splanchnic perfusion in patients undergoing coronary artery bypass grafting

“…Traditionally, a variety of fluid regimes have been used around induction of general anaesthesia to ameliorate these combined effects of pre-operative fluid deficit, vasodilation and the cardiovascular depressant actions of anaesthetic drugs [12,13]. This study was designed to investigate the effect of a pre-operative infusion of crystalloid solution (to allow for the patients' maintenance requirements overnight, calculated as 1.5 ml.kg )1 .h )1 ) on pre-operative haemodynamic data, global oxygenation parameters and splanchnic perfusion.…”