Cardiovascular Effects of Propofol and of Thiopentone Anaesthesia in the Sheep

Runciman, William B.; Mather, Laurence E.; Selby, Debbie

doi:10.1093/bja/65.3.353

Cited by 55 publications

(30 citation statements)

References 13 publications

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“…Isoflurane at 1 MAC also depresses mean arterial pressure in humans by ≈ 25%, mainly as a function of decreasing systemic vascular resistance with little effect on cardiac output ( Stevens et al ., 1971 ). Propofol at similar doses has been shown to increase heart rate and blood pressure without affecting cardiac output in sheep ( Runciman et al ., 1990 ).…”

Section: Discussionmentioning

confidence: 99%

A comparison of the haemodynamic effects of propofol and isoflurane in pregnant ewes

Gaynor

Alvis

et al. 1998

Vet Pharm & Therapeutics

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The purpose of this study was to compare the effects of inhaled isoflurane and a constant infusion of propofol on maternal haemodynamics and uterine arterial and umbilical venous flows in pregnant ewes. Late term pregnant ewes (n = 5) were randomly assigned to receive either inhaled isoflurane or an intravenous infusion of propofol for 1 h, each on separate occasions. Maternal systemic arterial, right atrial and pulmonary arterial blood pressures, cardiac index, systemic vascular resistance index, stroke volume index, heart rate, and uterine arterial and umbilical venous flows were determined over the 1 h period of each treatment. Data were analysed using an univariate analysis of variance for repeated measures performed on the ranks of the data. Propofol anaesthetized ewes had significantly higher heart rate (P = 0.0040), mean arterial pressure (P = 0.0003) and cardiac index (P = 0.0475) compared to isoflurane anaesthetized ewes. There were no significant differences in uterine arterial flows, umbilical venous flows, or other measured variables. Continuous propofol infusions maintain maternal haemodynamics at significantly higher levels than does inhaled isoflurane, while uterine arterial and umbilical venous flows do not differ significantly.

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Section: Discussionmentioning

confidence: 99%

A comparison of the haemodynamic effects of propofol and isoflurane in pregnant ewes

Gaynor

Alvis

et al. 1998

Vet Pharm & Therapeutics

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“…4 In contrast, studies in dogs established that propofol had no effect on HBF, HaBF, or PvBF. 5,8 As a final point, other animal studies have reported a reduction in hepatic blood flow 3,6,7 A number of explanations for these discrepancies are feasible: differences in drug dos- ‡P < 0.05 vs t 60 in the Group C; *P < 0.05 vs t 0 in the Group P; #P < 0.05 vs t 10 in the Group P. hDO 2 = total hepatic oxygen delivery; hVO 2 = total hepatic oxygen consumption; ShvO 2 = hemoglobin oxygen saturation in hepatic vein; ErO 2 = hepatic oxygen extraction ratio.…”

Section: Effect Of Propofol Infusion On Hepatic Blood Flowmentioning

confidence: 94%

“…Despite these limitations, with appropriate precautions, electromagnetic flowmeters provide an accurate measure of blood flow. 9,11 Studies measuring blood flow, using indirect methods such as indictor dye clearance 3,6,7 or radio labelled microspheres, 4,5 are susceptible to experimental error, and their calculations require numerous assumptions. 7,[9][10][11] One common finding is the apparent inhibition of the hepatic arterial buffer response.…”

Section: Effect Of Propofol Infusion On Hepatic Blood Flowmentioning

confidence: 99%

Effect of propofol on hepatic blood flow and oxygen balance in rabbits

Zhu

Pang

McCluskey

et al. 2008

Can J Anesth/J Can Anesth

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reports of original investigations CAN J ANESTH 55: 6 www.cja-jca.org June, 2008 Purpose: Propofol has been reported to alter hepatic blood flow and to increase hepatic oxygen consumption. This study was designed to determine the effect of propofol on hepatic blood flow and oxygenation in rabbits, in order to establish its net effect on hepatic oxygen balance.Methods: Twenty, adult male, New Zealand white rabbits were randomly divided into two groups: Group P (propofol, 0.6 mg·kg). An electromagnetic flowmeter was used to measure hepatic blood flow, and blood, from the carotid artery, the portal vein, and the hepatic vein, was used to determine hepatic oxygenation. After we obtained baseline values, we repeated measurements ten, 30, and 60 min after initiating the infusion.Results: Intralipid did not affect systemic hemodynamics, hepatic blood flow, or oxygenation during the 60 min infusion; however, propofol caused a time-dependent decrease in mean arterial blood pressures and an increase in portal venous flow and total hepatic blood flow. In contrast, hepatic arterial blood flow remained unchanged during the propofol infusion. Hepatic oxygen delivery and consumption increased in a time-dependent manner to maximums of 25% and 21.4% (both, P < 0.05) above baseline, respectively. Hepatic venous oxygen saturation and extraction was unchanged throughout the study period. Conclusion:Propofol increases total hepatic blood flow, primarily by increasing hepatic portal venous flow. The increase in liver oxygen consumption was fully compensated by an increase in oxygen supply to the liver, resulting in a preserved, hepatic oxygen balance.

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“…Although propofol has been reported to affect haemodynamics by negative inotropy and vasodilation, its effect on renal blood flow in healthy subjects is minimal 33,34 . While propofol may reduce renal function, similar to other anaesthetic compounds, in healthy animals, the depression in renal blood flow appears to be less than that during anaesthesia induction using volatile anaesthetics 35 .…”

Section: Discussionmentioning

confidence: 99%

Kısa-Etkili Anesteziklerin Tavşanlarda Hemodinamik Fonksiyonlara Etkilerinin Doppler Ultrasonografi ile Değerlendirilmesi

Kaya¹,

Pekcan²,

Şen³

et al. 2009

Kafkas Univ Vet Fak Derg

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SummaryThis study was carried out to determine the effects of short-acting anaesthetics on haemodynamic function determined by Doppler ultrasonography. Prior to anaesthesia, Doppler parameters [peak systolic blood flow velocity (psBFV), end-diastolic blood flow velocity (edBFV), minimum diastolic blood flow velocity (mdBFV) and resistive index (RI)] were obtained from the right common carotid artery (CCA), abdominal aorta (AA) and right kidney in New Zealand rabbits (n=24). Animals were then divided into 3 groups to be anaesthetized with propofol (Group P), 2.5% thiopental sodium (Group T) and xylazine/ketamine HCl (Group XK). During anaesthesia the same Doppler measurements were made. Compared with baseline values, psBFV obtained from CCA increased in Group P (P<0.02) and insignificantly changed in Groups T and XK. psBFV measured from AA in Groups T and XK decreased as compared with baseline values. In the right kidney, psBFV in Group P and edBFV in Group T increased, whereas RI value in Groups T and XK decreased. In conclusion, comparing baseline values, propofol anaesthesia did not significantly alter RI measured from CCA and kidney and blood flow velocities measured from AA. The data suggest that propofol anaesthesia in rabbits results in minimal changes in Doppler parameters. Keywords: Short-acting anaesthetic, Haemodynamic function, Doppler ultrasonography, Rabbit Kısa-Etkili Anesteziklerin Tavşanlarda Hemodinamik Fonksiyonlara Etkilerinin Doppler Ultrasonografi ile Değerlendirilmesi ÖzetBu çalışma, kısa etkili anesteziklerin Doppler ultrasonografi ile saptanan hemodinamik fonksiyonlara etkilerini belirlemek amacıyla yürütüldü. Anestezi öncesi Yeni Zelanda tavşanlarının (n=24) sağ arteria carotis communis (CCA), aorta abdominalis (AA) ve sağ böbreğinden Doppler parametreleri [en yüksek sistolik kan akım hızı (psBFV), diyastol sonu kan akım hızı (edBFV), en düşük diyastolik kan akım hızı (mdBFV) ve rezistif indeks (RI)] elde edildi. Hayvanlar propofol (Grup P), %2.5 tiyopental sodyum (Grup T) ve ksilazin/ ketamin HCl (Grup XK) ile anestezi altına alınarak, üç grup oluşturuldu. Anestezi sırasında aynı ölçümler tekrarlandı. Bazal değerler ile karşılaştırıldığında CCA'dan elde edilen psBFV Grup P'de yükseldi ve Grup T ve XK'daki değişim önemsizdi. Grup T ve XK'da AA'dan ölçülen psBFV bazal değerler ile kıyaslandığında azaldı. Sağ böbrekte, Grup P'nin psBFV ve Grup T'nin edBFV değerleri artarken, Grup T ve XK'da RI değeri azaldı. Sonuç olarak, propofol anestezisi bazal parametreler ile karşılaştırıldığında, CCA'deki RI, intrarenal RI ve AA'daki kan akımı hızlarını önemli ölçüde değiştirmediği tespit edildi. Veriler propofol anestezisinin tavşanlarda Doppler parametrelerini minimal düzeyde etkilediğini göstermektedir.

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Cardiovascular Effects of Propofol and of Thiopentone Anaesthesia in the Sheep

Cited by 55 publications

References 13 publications

A comparison of the haemodynamic effects of propofol and isoflurane in pregnant ewes

A comparison of the haemodynamic effects of propofol and isoflurane in pregnant ewes

Effect of propofol on hepatic blood flow and oxygen balance in rabbits

Kısa-Etkili Anesteziklerin Tavşanlarda Hemodinamik Fonksiyonlara Etkilerinin Doppler Ultrasonografi ile Değerlendirilmesi

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