Cardiovascular health and cognitive function among Mexican older adults: cross-sectional results from the WHO Study on Global Ageing and Adult Health

Perales, Jaime; Hinton, W Ladson; Burns, Jeffrey M.; Vidoni, Eric D.

doi:10.1017/s1041610218000297

Cited by 7 publications

(15 citation statements)

References 40 publications

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“…19,20,[22][23][24][25][26]34 However, in the present study, we found that such associations exist among individuals aged 65 and over. 19,20,[22][23][24][25][26]34 However, in the present study, we found that such associations exist among individuals aged 65 and over.…”

Section: Discussioncontrasting

confidence: 86%

“…[19][20][21][22][23][24][25][26][27]34 Findings are consistent with the Framingham study in that the 0 to 14 continuous CVH index was not associated with dementia incidence. In line with our hypothesis, we found that moderate and ideal levels of CVH were associated with a lower dementia incidence than poor levels.…”

Section: Discussionsupporting

confidence: 85%

“…These findings are in line with a growing literature showing that cumulative indices of modifiable CVH factors are associated with stroke, cognitive functioning, decline, brain integrity, and dementia. [19][20][21][22][23][24][25][26][27]34 Findings are consistent with the Framingham study in that the 0 to 14 continuous CVH index was not associated with dementia incidence. 21 Results are also similar to those in the REGARDS study, which found a lower cognitive impairment incidence among an ethnically diverse American middle-aged adult sample with moderate and ideal CVH levels in a diverse sample of middle agers.…”

Section: Discussionsupporting

confidence: 85%

“…Recentfindings support this idea as comorbid depression and diabetes significantly increased risk for mild cognitive impairment and Alzheimer disease among Mexican-Americans 50. Our previous study found that a similar four-component index was associated with cognitive functioning cross-sectionally in a representative sample of Mexicans 50 and older 34. Our previous study found that a similar four-component index was associated with cognitive functioning cross-sectionally in a representative sample of Mexicans 50 and older 34.…”

mentioning

confidence: 54%

“…For the present analyses, the total score was the sum of all criteria ranging from 0 to 14, which we also categorized into three groups on the basis of data distribution (0-5, 6-10, and 11-14) since studies that show associations may not be linear. 23,26,34…”

Section: Cvh Indexmentioning

confidence: 99%

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Cardiovascular health and dementia incidence among older adults in Latin America: Results from the 10/66 study

Perales‐Puchalt

Vidoni

Rodriguez

et al. 2019

Int J Geriat Psychiatry

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Objectives Growing evidence shows that cardiovascular health (CVH) is associated with brain health. Little is known about this topic among older adults in Latin America, where the number of people living with dementia is rising. This study aimed to assess the longitudinal association between CVH and dementia in six Latin American countries. Methods We analyzed longitudinal data from the 10/66 study that included nondementia residents at baseline aged 65+ in six Latin American countries (n = 6447) and were followed up for 3 years. An index of modifiable CVH factors (ranging from 0 to 14) was calculated. Incident dementia was modeled using competing risk regression to adjust for risk of death. Results The sample included 6.2% participants with poor (0‐5), 81.0% with moderate (6‐10), and 12.8% with ideal CVH (11‐14). At follow‐up, 9.4% had developed dementia and 13.1% had died. Compared with those with poor CVH, participants with moderate and ideal levels of CVH had a significantly lower risk of dementia in both the unadjusted (subhazard ratio for moderate, 0.77; ideal, 0.59) and adjusted models (moderate, 0.73; ideal, 0.66). Conclusion Moderate and ideal levels of CVH in old age may protect against dementia incidence. These findings may inform health promotion efforts within dementia national plans adopted recently in some Latin American countries.

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Section: Discussioncontrasting

confidence: 86%

Section: Discussionsupporting

confidence: 85%

Section: Discussionsupporting

confidence: 85%

mentioning

confidence: 54%

Section: Cvh Indexmentioning

confidence: 99%

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Cardiovascular health and dementia incidence among older adults in Latin America: Results from the 10/66 study

Perales‐Puchalt

Vidoni

Rodriguez

et al. 2019

Int J Geriat Psychiatry

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Effects of diabetes and obesity on cognitive impairment and mortality in older mexicans

Milani

López

Downer³

et al. 2022

Archives of Gerontology and Geriatrics

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Independent and joint effects of vascular and cardiometabolic risk factor pairs for risk of all-cause dementia: a prospective population-based study

Shaaban

Jia

Chang

et al. 2019

Int. Psychogeriatr.

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Objectives:To assess independent and joint effects of pairs of vascular and cardiometabolic risk factors (VCMRFs) in relation to risk of all-cause dementia.Design:Population-based longitudinal cohort study of cognitive impairment. We used an algorithm to select pairs of VCMRFs and tested their joint effects in time-dependent Cox models. We used attributable proportions (AP) to measure the proportion of risk from interactions beyond any additive effect.Setting:Economically depressed small-town population.Participants:Adults age 65+ years with up to 10 yearly study visits (N=1701, median (Q1, Q3) age, 78 (71.0, 83.0), 62.3% female, 94.9% white).Results:Among 1701 participants free from prevalent dementia with at least one follow-up visit, 109 developed incident all-cause dementia. In pairings of APOE*4 with hypertension (HTN) and congestive heart failure (CHF), the variables contributed independently and additively to all-cause dementia risk. In pairings of APOE*4 with stroke and stroke with CHF, the variables demonstrated independent contributions to all-cause dementia risk; their joint effects showed excess detriment demonstrating synergistic interactions (joint HR [95% CI]: 28.33 [6.74, 119.01] and 50.30 [14.57, 173.57] respectively, fully adjusted models). Physical activity (PA) was independently associated with lower all-cause dementia risk when paired with APOE*4, stroke, and CHF in unadjusted models; these associations did not survive covariate adjustment. The joint effect of low PA and APOE*4 was associated with additively increased all-cause dementia risk (joint HR [95% CI]: 4.61 [2.07, 10.23], fully adjusted model).Conclusions:Reduction of VCMRFs, including low PA, could be valuable for dementia prevention, especially among APOE*4 carriers.

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Cardiovascular health and cognitive function among Mexican older adults: cross-sectional results from the WHO Study on Global Ageing and Adult Health

Abstract: If longitudinal research confirms these findings, results would suggest that dementia-related policies in Mexico need to focus on achieving optimal levels of cardiovascular health, especially in midlife.

Cited by 7 publications

References 40 publications

Cardiovascular health and dementia incidence among older adults in Latin America: Results from the 10/66 study

Cardiovascular health and dementia incidence among older adults in Latin America: Results from the 10/66 study

Effects of diabetes and obesity on cognitive impairment and mortality in older mexicans

Independent and joint effects of vascular and cardiometabolic risk factor pairs for risk of all-cause dementia: a prospective population-based study

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