Cardiovascular manifestations in hyperthyroidism

Kandan, Vairamani; P, Sathyamurthy; Rajkumar, M; Narayanan, Lavanya

doi:10.18203/2320-6012.ijrms20161999

Cited by 9 publications

(19 citation statements)

References 9 publications

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“…In the present study, tachycardia (heart rate >100/min) was present in 65.3%, which was similar to the study conducted by Zarger et al 7 This finding correlated well with the study conducted by Kandan et al, 5 in which tachycardia was found in 46% patients.…”

Section: Parameterssupporting

confidence: 93%

“…In the study conducted by Kandan et al 5 cardiac chamber enlargement was observed in 18% of study population. Twelve patients (16%) had left ventricular hypertrophy.…”

Section: Parametersmentioning

confidence: 79%

“…The common cardiovascular symptoms in the study conducted by Kandan et al 5 were palpitation (78%), followed by dyspnea (26%) and chest pain (4%). Though the most common symptom was palpitation in our study too, the percentage was less (49.3%).…”

Section: Parametersmentioning

confidence: 88%

“…The prevalence of atrial fibrillation in the study conducted by Zarger et al 7 was 8.9%, Osman et al 8 was 6% and Dhadke et al 9 was 11.4% among patients with thyrotoxicosis. Kandan et al 5 reported atrial fibrillation in 28% and Bar-Sela et al 10 reported in 21%. Prevalence of atrial fibrillation was observed in 5.5 % (3 out of 55 cases) of Grave's disease , 20 % of Thyroiditis (2 out of 10cases) and 30 % of MNG (3 out of 10 cases) amongst study population and this difference was statistically significant.…”

Section: Parametersmentioning

confidence: 98%

“…Grave 5 . Thyroid hormones have a profound effect on numerous metabolic processes, virtually in all tissues and hence every tissue in the body gets affected to a greater or lesser extent in thyroid hormone disturbances, the heart being particularly sensitive to its effect.…”

Section: Parametersmentioning

confidence: 99%

See 4 more Smart Citations

Cardiovascular Manifestations in Patients With Thyrotoxicosis Based on Aetiology

Shetty¹,

Acharya²,

Khan³

2018

jebmh

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Section: Parameterssupporting

confidence: 93%

“…In the study conducted by Kandan et al 5 cardiac chamber enlargement was observed in 18% of study population. Twelve patients (16%) had left ventricular hypertrophy.…”

Section: Parametersmentioning

confidence: 79%

Section: Parametersmentioning

confidence: 88%

Section: Parametersmentioning

confidence: 98%

Section: Parametersmentioning

confidence: 99%

See 3 more Smart Citations

Cardiovascular Manifestations in Patients With Thyrotoxicosis Based on Aetiology

Shetty¹,

Acharya²,

Khan³

2018

jebmh

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Thyrotoxicosis and dilated cardiomyopathy in developing countries

Abera

Berhe

et al. 2021

BMC Endocr Disord

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Background Thyrotoxicosis is the state of thyroid hormone excess. But, in sub-Saharan Africa (SSA), specifically Northern Ethiopia, scientific evidence about thyrotoxicosis and its cardiac complications like dilated cardiomyopathy is limited. Therefore, this study aimed to explore the thyrotoxicosis presentation and management and identify factors associated with dilated cardiomyopathy in a tertiary hospital in Northern Ethiopia. Methods An institution-based cross-sectional study was conducted in Ayder Comprehensive Specialized Hospital from 2017 to 2018. Data from 200 thyrotoxicosis cases were collected using a structured questionnaire. After describing variables, logistic regression was conducted to identify independent predictors of dilated cardiomyopathy. Statistical significance was declared at p < 0.05. Results Mean age at presentation of thyrotoxicosis was 45 years and females accounted for 89 % of the cases. The most frequent etiology was multinodular toxic goiter (51.5 %). As well, the most common symptoms and signs were palpitation and goiter respectively. Thyroid storm occurred in 6 % of the cases. Out of 89 patients subjected to echocardiography, 35 (39.3 %) of them had dilated cardiomyopathy. And, the odds of dilated cardiomyopathy were higher in patients who had atrial fibrillation (AOR = 15.95, 95 % CI:5.89–38.16, p = 0.001) and tachycardia (AOR = 2.73, 95 % CI:1.04–7.15, p = 0.040). All patients took propylthiouracil and 13.0 % of them experienced its side effects. Concerning β-blockers, propranolol was the most commonly (78.5 % of the cases) used drug followed by atenolol (15.0 %). Six patients underwent surgery. Conclusions In developing countries like Ethiopia, patients with thyrotoxicosis have no access to methimazole which is the first-line anti-thyroid drug. Besides, they greatly suffer from dilated cardiomyopathy (due to late presentation) and side effects of propylthiouracil. Therefore, we recommend that patients should get adequate health information about thyrotoxicosis and anti-thyroid drugs including their side effects. Additionally, hospitals and other concerned bodies should also avail of TSH tests and methimazole at an affordable cost. Furthermore, community awareness about iodized salt and iodine-rich foods should be enhanced.

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Study of Cardiovascular Manifestations in Patients with Thyroid dysfunction at Tertiary Care Center

Berad¹,

Chaudhari²,

Chafekar³

2021

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Introduction: Thyroid hormones have effects on virtually every organ system. The heart is the major target organ for thyroid action. It was thought that thyroid disorder is a circulatory disorder and manifestations of thyroid disorders are due to changes in cardiac work. Over the period it has become clear that the explanation for the altered circulatory hemo-dynamics of thyroid disease is because of involvement of cardiovascular system. Aims and Objectives: To find out the incidence of overt and subclinical cardiac manifestations in patients with thyroid dysfunction and to compare the prevalence of overt and subclinical cardiac manifestations in two subsets of patients belonging to hyperthyroid and hypothyroid groups respectively. Materials and Methods: It was an observational study carried out at the Department of Medicine for the period of August 2017 to December 2019. In total, 230 newly diagnosed patients with thyroid dysfunction were included in the study. Focused clinical and detailed cardiovascular system examination, necessary biochemical investigations were done. All patients underwent detailed 12 lead electrocardiogram and 2D Echo-cardiography procedure. Incidence of overt and subclinical cardiac manifestations in Hyperthyroid and Hypothyroid cases was calculated; and the Prevalence of overt and subclinical manifestations in the two subsets of patients belonging to Hyperthyroid and Hypothyroid groups respectively was compared and data was analyesd. Results: Total hypothyroid patients were 115 and that of hyperthyroid were 115. Incidence of thyroid is much more common in females as compared to males (81% in hyperthyroidism and 92% in hypothyroidism). In hyperthyroid group, 92% patients showed cardiac involvement either in the form of ECG, CXR, 2D ECHO abnormalities and in hypothyroid patients it was 93%. Statistically significant patients presented with symptoms of congestive cardiac failure in hyperthyroid group (73%) but not in hypothyroid group. In the both groups, fatigue was the most commonest presenting symptom related to cardiovascular system. In hypothyroid group, most common cardiac sign was Pulse, Pressure<40 mm of Hg (73%) whereas in hyperthyroidism it was sinus tachycardia (73%). 73% hyperthyroid patients showed sinus tachycardia as the most common ECG finding where again 73% hypothyroid patients showed ST-T changes as a most common ECG finding. Nearly 70% hyperthyroid patients had ejection fraction more than 60% on Echocardiogrphy the procedure and almost all patients of hypothyroidism had ejection fraction less than 60%. Conclusion: Thyroid dysfunction was found to be more common in the females with 41-50 years of age group in hypothyroidism group and 21-30 years in the hyperthyroidism group. Cardiovascular manifestations were the major presenting factors in both the groups pointing towards the adverse effects of thyroid dysfunction, Dyspnea and fatigue were the major cardiac symptoms in the hypothyroidism group. While chest pain and fatigue were the major cardiac symptoms in the hyperthyroidism group. The ECG and 2D ECHO findings in the current study also suggested that in both the groups of thyroid dysfunction, cardiac manifestations are likely to have higher incidence.

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Cardiovascular manifestations in hyperthyroidism

Cited by 9 publications

References 9 publications

Cardiovascular Manifestations in Patients With Thyrotoxicosis Based on Aetiology

Cardiovascular Manifestations in Patients With Thyrotoxicosis Based on Aetiology

Thyrotoxicosis and dilated cardiomyopathy in developing countries

Study of Cardiovascular Manifestations in Patients with Thyroid dysfunction at Tertiary Care Center

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