Cardiovascular Pharmacology of the Domestic Fowl

Buñag, Ruben D.; Walaszek, Edward J.

doi:10.1254/jjp.11.171

Cited by 9 publications

(3 citation statements)

References 61 publications

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“…14 The same compounds were unable to antagonize the convulsions induced by pentylenetetrazole15 or strichnine16 and to interfere with the motor coordination in mice as assessed by the performance on the rotating rod test.17 Furthermore, 29 was as active as imipramine in antagonizing serotonin-induced contraction of the isolated guinea-pig ileum. 18 Experimental Section Synthetic Procedures. Melting points were taken in open capillary tubes using a Tottoli apparatus (N. Buchi, Flawil, Switzerland) and are uncorrected.…”

Section: Resultsmentioning

confidence: 99%

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Basic derivatives of 6,7-dihydroindolo[1,7-ab][1]benzazepine and 6H-indolo[7,1-cd][1,5]benzoxazepine as potential antidepressant agents

Toscano¹,

Grisanti²,

Fioriello³

et al. 1976

J. Med. Chem.

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Basic derivatives of 6,7-dihydroindolo[1,7-ab][1]benzazepine and 6H-indolo[7,1-cd][1,5]benzoxazepine incorporating the imipramine basic side chain were synthesized and screened for antidepressant activity in mice. With few exceptions, the compounds unsubstituted at C-2 antagonized reserpine-induced ptosis and hypothermia showing negligible anticholinergic and antihistaminic properties. The compound 1-[2-(N-methyl-N-benzylamino)ethyl]-6,7-dihydroindolo[1,7-ab][1]benzazepine had the highest toxicity-activity ratio.

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Section: Resultsmentioning

confidence: 99%

“…After 30 hr at 20-25°, the Et20 was evaporated and the crude product was purified by column chromatography on Florisil (ratio 1:30) using CeHe as eluent. The collected fractions gave 7.6 g of 18 which was used in the next step without further purification. [l]benzazepine-l-(jV-benzyl-N-methylacetamide) (22) (Table III, 20-23).…”

Section: Resultsmentioning

confidence: 99%

Basic derivatives of 6,7-dihydroindolo[1,7-ab][1]benzazepine and 6H-indolo[7,1-cd][1,5]benzoxazepine as potential antidepressant agents

Toscano¹,

Grisanti²,

Fioriello³

et al. 1976

J. Med. Chem.

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show abstract

“…2 or with epinephrine in either experiment. The injection of serotonin has been demonstrated to cause a decrease in blood pressure in chickens presumably via histamine release (8). Serotonin did not significantly influence leg scores in either experiment.…”

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confidence: 78%