Cardiovascular Responses to Nitrous Oxide Exposure for Two Hours in Man

KAWAMURA, R.; STANLEY, T. H.; ENGLISH, J. B.; HILL, G. E.; LIU, W. -S.; WEBSTER, L. R.; Kern, F.

doi:10.1097/00132586-198102000-00015

Cited by 3 publications

(5 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Many years of clinical experience with N 2 O indicate that it possesses mild cardiovascular depressant effects that may be counterbalanced by a simultaneous, reflexly mediated increase in sympathetic tone. These studies demonstrated small increases, 22 small decreases, 23 or no change 24 in indices of contractility. A few in vitro investigations regarding the effects of N 2 O on myocardial muscle have indicated that N 2 O depressed contractility similar to, or more than that in controls.…”

Section: 516mentioning

confidence: 80%

Xenon and nitrous oxide do not depress cardiac function in an isolated rat heart model

Nakayama¹,

Takahashi

Okubo

et al. 2002

Can J Anesth/J Can Anesth

View full text Add to dashboard Cite

Section: 516mentioning

confidence: 80%

Xenon and nitrous oxide do not depress cardiac function in an isolated rat heart model

Nakayama¹,

Takahashi

Okubo

et al. 2002

Can J Anesth/J Can Anesth

View full text Add to dashboard Cite

“…The decreases in systolic blood pressure and heart rate were found greater with increasing concentration of N 2 O. In literature one clinical report has stated that the use of a high concentration (60%) of N 2 O at the beginning caused cardiovascular stimulation was reduced with gas inhalation which continued for a long time [18]. In a study by Turan et al [22], while intraoperative MAP and HR values were found to be similar in patients on whom N 2 O was used and not used, a difference was seen in the Enigma study [23].…”

Section: Discussionmentioning

confidence: 94%

“…In previous studies, it has been reported that N 2 O has shown effects on cardiovascular contractility such as minimal increase, decrease or no change [18][19][20]. In the study of Henry et al [21], the cardiovascular effect of 20%, 40%, 60% concentrations of N 2 O were investigated in both spontaneously hypertensive rat and normotensive Wister-Kyoto counterpart.…”

Section: Discussionmentioning

confidence: 99%

The Effects Of Nitrous Oxide On Postoperative Pain, Nausea Vomiting and Intraoperative Haemodynamics in Robotic Gynecologic Surgery

Yanli¹

2017

SDRP-JAS

View full text Add to dashboard Cite

BACKGROUND n recent years there has been an increase in gynaecological operations performed with robotic surgery. In these procedures, nitrous oxide(N 2 O) or air are used together with inhalation anaesthestics. In this study we aimed to compare the effects of O 2 /N 2 O or O 2 /Air on postoperative pain, nausea vomiting (PONV) and intraoperative thermodynamics in robotic surgery. METHODSAged 28-71 years, classified ASA I-II, 58 patients were separated into 2 groups. Following induction, anaesthesia was maintained O 2 /Air (Group A) or O 2 /N 2 O (Group N) with sevoflurane. Heart rate (HR), mean arterial pressure (MAP), Central Venous Pressure (CVP), end tidal carbon dioxide (ETCO 2 ), peripheral oxygen saturation (SpO 2 ), Aldrete recovery score (ARS), postoperative nausea and vomiting (PONV) and visual analog scale (VAS) were recorded during the operation and postoperative period. RESULTSThe VAS values were higher in Group N at 5th min and higher in Group A at 150th min (p<0.05). In the intragroup analysis, VAS values were significantly lower at 120th, 150th, 180th min compared with 5th, 15th, 30th and 60th min in Group N (p<0.05). In Group A, the values at 15th, 30th min was significantly higher than 60th, 120th and 180th min (p<0.05). Intraoperative haemodynamic parameters (HR, MAP, CVP) were similar in two groups (p>0.05). Intragroup analysis of PONV values were significantly lower at 150th and 180th min compared with both 5th and 30th min in Group N and significantly higher at 5th min compared with 180th min in GroupA(p<0.05). CONCLUSIONWith regard to acute postoperative analgesia we could not find any significant difference between N 2 O and air. Further clinical studies are required to investigate this subject in respect of differences (at 5th min and at 150th min) in the VAS scores.

show abstract

“…Dube et al 13 also observed that HR and MBP were lower in the N 2 O-propofol group, and attributed it to additive analgesic effect of N 2 O. N 2 O can produce direct myocardial depression. 19 However, this is compensated by the simultaneous sympathetic activation of the brain nuclei which control β-adrenergic activity. 20 In addition, N 2 O can also inhibit the uptake of noradrenaline by the lungs, which results in α-adrenergic stimulation.…”

Section: Resultsmentioning

confidence: 99%

“…20 In addition, N 2 O can also inhibit the uptake of noradrenaline by the lungs, which results in α-adrenergic stimulation. 19 Some cardiovascular depression is the net result. In contrast, Carlier et al 21 found that the inhalation of 70% N 2 O in oxygen did not alter the haemodynamic variables during propofol induction.…”

Section: Resultsmentioning

confidence: 99%

A prospective, randomised, controlled clinical trial to evaluate the effect of nitrous oxide on propofol requirement in elective craniotomy in which entropy was used to measure depth of anaesthesia

Nanda

Prakash

Choudhury

et al. 2016

Southern African Journal of Anaesthesia and Analgesia

View full text Add to dashboard Cite

Open Access article distributed under the terms of the Creative Commons License [CC BY-NC-ND 4.0] http://creativecommons.org/licenses/by-nc-nd/4.0 A prospective, randomised, controlled clinical trial to evaluate the effect of nitrous oxide on propofol requirement in elective craniotomy in which entropy was used to measure depth of anaesthesia Background: Propofol is known to have a favourable effect on cerebral haemodynamics. The role of nitrous oxide (N 2 O) in neurosurgical anaesthesia is still being debated. The primary aim of this study was to assess the dose-sparing effect of N 2 O on propofol infusion maintenance dosing. Method: Fifty American Society of Anesthesiology (ASA) grade I and II adults scheduled for elective craniotomies for supratentorial tumours were enrolled in the study. The patients received a standard anaesthetic comprising a fentanyl 2 μg/kg bolus prior to propofol induction. Anaesthesia was maintained with an infusion of fentanyl (2 μg/kg/hour), atracurium and propofol. The patients were randomised into two groups. Group A received 67% N 2 O. Group B did not receive N 2 O concomitantly with the propofol infusion. Entropy was used to guide the titration of the propofol infusion in both groups. Results: The propofol maintenance dose requirements were 47% lower in Group A (54.30 ± 11.47 μg/kg/minute) vs. Group B (102.30 ± 14.00 μg/kg/minute), (p < 0.001). Conclusion: The use of supplemental N 2 O significantly decreased propofol infusion rate requirements, compared with the propofol infusion alone, in ASA I and II patients undergoing elective supratentorial tumour excision.

show abstract

Cardiovascular Responses to Nitrous Oxide Exposure for Two Hours in Man

Cited by 3 publications

References 0 publications

Xenon and nitrous oxide do not depress cardiac function in an isolated rat heart model

Xenon and nitrous oxide do not depress cardiac function in an isolated rat heart model

The Effects Of Nitrous Oxide On Postoperative Pain, Nausea Vomiting and Intraoperative Haemodynamics in Robotic Gynecologic Surgery

A prospective, randomised, controlled clinical trial to evaluate the effect of nitrous oxide on propofol requirement in elective craniotomy in which entropy was used to measure depth of anaesthesia

Contact Info

Product

Resources

About