Cardiovascular risk factor control and outcomes in peripheral artery disease patients in the Reduction of Atherothrombosis for Continued Health (REACH) Registry

Cacoub, Patrice; Abola, Maria Teresa B.; Baumgartner, Iris; Bhatt, Deepak L.; Creager, Mark A.; Liau, Chiau Suong; Goto, Shinya; Röther, Joachim; Steg, Philippe Gabriel; Hirsch, Alan T.

doi:10.1016/j.atherosclerosis.2008.10.023

Cited by 230 publications

(183 citation statements)

References 24 publications

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“…Furthermore, overestimation of the treatment given by others, lack of education, training, and organizational facilities to implement guidelines properly play a role,48 as well as the beliefs of the physician themselves 49. Cacoub et al showed that the extent of risk factor management was significantly associated with the type of doctor that treated the PAD patient 50. Hackam et al calculated in a systematic review and modeling study that more widespread implementation of antiplatelet therapy, statins, and ACE inhibition (85% use of each) in the PAD population may prevent more than 200 000 cardiovascular events each year (myocardial infarction, stroke, and cardiovascular death; 212 166 events; 95% CI 95 823–310 392) in North America and Western Europe alone 51…”

Section: Trends In Medical Therapy For Padmentioning

confidence: 99%

Critical Limb Ischemia: Current Trends and Future Directions

Teraa

Conte

Moll

et al. 2016

JAHA

207

150

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Section: Trends In Medical Therapy For Padmentioning

confidence: 99%

Critical Limb Ischemia: Current Trends and Future Directions

Teraa

Conte

Moll

et al. 2016

JAHA

207

150

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“…TASC-II reports that half of patients with PAD have concomitant CAD 1) , and the baseline data in the REduction of Atherothrombosis for Continued Health (REACH) registry indicate that 25.5% and 29.7% of PAD patients have a history of acute myocardial infarction (AMI) and stable angina, respectively, worldwide 20) . Among the Japanese population in the REACH registry, 27.8% of the PAD patients had a history of CAD 21) , and Hirose et al found a prevalence of concomitant CAD of 55% in Japanese patients with PAD using pharmacologic stress singlephoton emission computed tomography 22) .…”

Section: Discussionmentioning

confidence: 99%

High-sensitivity C-reactive Protein, Lipoprotein(a) and Homocysteine are Risk Factors for Coronary Artery Disease in Japanese Patients with Peripheral Arterial Disease

Kumakura

Fujita

Kanai

et al. 2015

JAT

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Aim:The goal of the study was to investigate the relationships between coronary artery disease (CAD) and risk factors, including the serum levels of high-sensitivity C-reactive protein (hs-CRP), lipoprotein(a) (Lp(a)) and homocysteine, in Japanese patients with peripheral arterial disease (PAD). Methods: Coronary angiography was performed in 451 patients with PAD, among whom the prevalence and clinical characteristics of CAD were analyzed. A multiple logistic analysis was used to evaluate the relationships between CAD and the risk factors. The relationships between the severity of coronary arterial lesions and the risk factors were evaluated using multiple regression analysis. Results: The prevalence of CAD (≥ 70% luminal diameter narrowing or a history of CAD) and coronary artery stenosis (≥ 50%) was 55.9% and 74.1%, respectively, and the rate of CAD (≥ 70%) with single-, double-and triple-vessel disease was 25.9%, 13.5% and 10.6%, respectively. The prevalence of diabetes was higher among the patients with CAD than among those without. The serum levels of hs-CRP, Lp(a), and homocysteine were higher in the patients with CAD, whereas the estimated glomerular filtration rates and HDL-cholesterol levels were lower in these patients. According to the multiple logistic analysis, CAD was related to diabetes (hazard ratio [

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“…Однако было показано, что больные ОЗАНК существенно реже (p<0,001) полу-чают необходимую терапию, чем пациенты с ИБС: бета-блокаторы получали 34% и 74% больных, соот-ветственно, аспирин -40% и 88%, иАПФ -31% и 57% [7]. Среди 8322 больных с симптомами ОЗАНК в включенных в исследование REACH в 2003-2004гг 64% принимали статины, 82% -антиагреганты и 44% -иАПФ [9]. В исследовании Hamilton в Канаде 31% больных получали статины, 59% -антиагре-ганты или антикоагулянты и 42% -иАПФ [10].…”

Section: результатыunclassified

Outpatient Follow-Up of the Lower Extremities Atherosclerosis Patients From Cardiologist Point of View

Sumin¹,

Косова²,

Medvedeva³

et al. 2016

Russ J Cardiol

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Цель. Изучить клинические характеристики больных с атеросклерозом арте-рий нижних конечностей с позиций кардиолога. Материал и методы. В исследование были включены 456 пациентов (372 (79%) мужчины и 84 (18,4%) женщины, медиана для возраста составила 63 лет, от 45 до 81 лет) с облитерирующим атеросклерозом артерий нижних конечно-стей. Пациенты были осмотрены кардиологом в рамках регистра на базе кли-ники Кемеровского кардиологического центра с 2009 по 2013гг. Для изучения были выделены две группы согласно принятой в России классификации ста-дии хронической ишемии сосудов нижних конечностей (ХИНК) (по Фонтену-Покровскому): I группа (n=196) -пациенты с ХИНК I-IIа стадией, II группа (n=260) -пациенты ХИНК IIб-IV стадией. Результаты. Среди больных облитерирующими заболеваниями артерий нижних конечностей отмечена высокая частота кардиоцеребральной патологии: наличие инфаркта миокарда в анамнезе выявлено у 34,4% больных, клинические проявле-ния стенокардии -у 48,5% больных, инсульт в анамнезе -у 14,3% больных, стенозы экстракраниальных артерий -у 12,3% больных. В то же время назначе-ние кардиоваскулярной протективной терапии было неоптимальным среди обследованных пациентов: статины принимали 64,5% больных, бета-блока-торы -65,6%, ингибиторы АПФ -52,4%. Отличий по частоте кардиоваскулярной патологии и получаемой терапии в группах с различной выраженностью облите-рирующими заболеваниями артерий нижних конечностей не отмечено. Заключение. Для повышения эффективности вторичной профилактики у больных облитерирующими заболеваниями артерий нижних конечностей целесообразно использовать новые организационные подходы на амбулатор-ном этапе их лечения.

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Cardiovascular risk factor control and outcomes in peripheral artery disease patients in the Reduction of Atherothrombosis for Continued Health (REACH) Registry

Cited by 230 publications

References 24 publications

Critical Limb Ischemia: Current Trends and Future Directions

Critical Limb Ischemia: Current Trends and Future Directions

High-sensitivity C-reactive Protein, Lipoprotein(a) and Homocysteine are Risk Factors for Coronary Artery Disease in Japanese Patients with Peripheral Arterial Disease

Outpatient Follow-Up of the Lower Extremities Atherosclerosis Patients From Cardiologist Point of View

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