Cardiovascular Risk Factors and Subclinical Atherosclerosis in Greek Adolescents with Polycystic Ovary Syndrome: Its Relationship with Body Mass Index

Garoufi, Anastasia; Pagoni, Athanasia; Papadaki, Maria; Marmarinos, Antonios; Karapostolakis, Georgios; Michala, Lina; Soldatou, Alexandra

doi:10.3390/children9010004

Cited by 11 publications

(8 citation statements)

References 46 publications

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“…Which Creates psychological effects on Women's daily routine 33 . Foodstuffs: Bodyweight combined with an improvement in "insulin sensitivity" has been showing an effective therapy for the metabolic and hormonal imbalances seen in People with PCOS 34 . INTERIOR COMPONENT Body Inflammation "PCOS" is associated with low-level body inflammation, which can raise the risk of atherogenesis.…”

Section: Hazard Level and Morphology Exterior Component Phenotypicmentioning

confidence: 99%

Prediction a woman having Polycystic Ovary Syndrome (PCOS) those having Insulin Resistance (IR)

Talib¹,

Khadija²,

Khan³

et al. 2022

PJMHS

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Background: "Polycystic Ovary Syndrome" (PCOS) has been identified as a hazard for growing diabetes. Although it indicates and symptoms of "Polycystic Ovary Syndrome" (PCOS) appear before the signs and symptoms of "Insulin resistance" (IR) first, According to an assumption "Insulin resistance" (IR) may have a part in developing PCOS instead of another factor. Insulin resistance caused by obesity modifies the function of the pituitary gland and hypothalamus in the brain, leading to an increase in the synthesis of androgenic hormones, which correlate to PCOS1. Aim: To analyze outcomes of insulin resistance in women having polycystic ovaries Methodology: A literature search was performed with the use of search engines. The following search engines provided the articles for this systematic review, PubMed, Medscape, NCBI, and Google Scholar. For article searching following keywords were used; Polycystic ovaries, insulin resistance. Results: As a literature review of 45 articles and only 39 were included in this review, it is found that the Mean age of all subjects was 24-37 years. Obese females were 20-30 years and non-obese were 18-34 years. Insulin resistance occurs in 70-95% of females who were obese and had PCOS and 30-75% of females who were lean and developed PCOS. Hirsutism was observed mostly in obese patients diagnosed of having PCOS. Incidence of Amenorrhea was found higher in lean patients. Conclusion: It is concluded that high insulin is not just a symptom of PCOS it's also one of the major drivers of this condition. Insulin resistance acts as a key factor of PCOS. It mostly occurs among people who are obese and had developed PCOS. Keywords: (PCOS) Polycystic Ovary Syndrome, Resistance, Insulin

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Section: Hazard Level and Morphology Exterior Component Phenotypicmentioning

confidence: 99%

Prediction a woman having Polycystic Ovary Syndrome (PCOS) those having Insulin Resistance (IR)

Talib¹,

Khadija²,

Khan³

et al. 2022

PJMHS

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“…Although the association between NAFLD and PCOS has been widely studied in adults, liver manifestations in adolescents with PCOS are largely unaddressed in the current literature. There are only seven original studies examining hepatic steatosis exclusively in adolescent patients [ 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 ]. Hepatic fibrosis has been assessed only in one study of PCOS patients, which included an adolescent sample [ 24 ].…”

Section: Introductionmentioning

confidence: 99%

“…Hepatic fibrosis has been assessed only in one study of PCOS patients, which included an adolescent sample [ 24 ]. Regarding the Greek population, NAFLD has been studied only in two adult PCOS samples and one adolescent sample [ 21 , 25 , 26 ]. Acknowledging this gap in the literature as well as PCOS’ metabolic implications and its comparable pathogenesis with NAFLD, we aimed to assess NAFLD and its risk factors in adolescents with PCOS.…”

Section: Introductionmentioning

confidence: 99%

The Burden of Non-Alcoholic Fatty Liver Disease in Adolescents with Polycystic Ovary Syndrome: A Case–Control Study

Giannouli

Efthymiou

Konidari

et al. 2023

JCM

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The aim of this case–control study was to assess the burden of non-alcoholic fatty liver disease (NAFLD) in adolescents with polycystic ovary syndrome (PCOS) and its associations with insulin resistance, hyperandrogenism, and other metabolic characteristics of the syndrome. A total of 87 Caucasian adolescent girls (47 with PCOS and 40 controls), aged 12.3–20.4 years, underwent blood sampling for glucose metabolism, hormonal and lipid profile, gynecological and liver ultrasound, and liver elastography. Indices of insulin resistance, liver steatosis, and liver fibrosis were calculated. NAFLD diagnosed by ultrasound was more prevalent in adolescents with PCOS than controls (22.7% vs. 6.1%, p = 0.046), and was also verified by liver steatosis indices. The latter was not apparent for hepatic fibrosis, as assessed by Fibroscan® and calculated indices. The homeostatic model assessment for insulin resistance (HOMA-IR) was found to predict NAFLD diagnosis by the liver fat score (LFS) index (β = 0.709, p = 0.002). Adolescents with PCOS and high free androgen index (FAI) presented worse NAFLD than those adolescents with PCOS and lower FAI. In addition, adolescents with PCOS and concurrent NAFLD had worse insulin sensitivity indices (HOMA-IR, QUICKI, and glucose to insulin ratio) than adolescents with PCOS alone. Adolescent insulin resistance could be considered a confounder of the association between PCOS and NAFLD.

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“…Continuous screening has focused on reducing possible remotely associated complications in the vasculature. Increased intima-media thickness (IMT) of the arterial walls associated with IR [5,6] is one of the screening methods. The atherogenic milieu among PCOS women causes widespread premature atherosclerosis in virtually every artery in the body [7].…”

Section: Introductionmentioning

confidence: 99%

Area Under the Curve of carotid artery Doppler as a sensitive marker of insulin sensitivity among Iraqi women with polycystic ovarian syndrome: a cross sectional study

Akram¹,

Nori²,

Zghair³

2023

It Journ Gyn Obs

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Objective. Polycystic ovarian syndrome (PCOS), a common endocrinopathy of reproductive-aged women, harbors increased insulin resistance (IR) and cardiovascular risk. Screening for associated health risks reduces morbidity and mortality. Measurement of intima-media thickness (IMT) by carotid artery Doppler (CCA) was tested as a marker for IR previously; herein, we aimed to verify the value of area under the curve (AUC) of CCA Doppler wave as a possible marker for IR in PCOS.Patients and Methods. 140 PCOS women were recruited from the ultrasound department of Al-Yarmouk Hospital; from CCA-Doppler, we recorded CCA-IMT, pulsatility index (PI), and resistance index (RI). By Graph software, AUC-CCA was calculated for all. Patients' biochemical (lipid and glucose) and hormonal parameters (FSH, LH, insulin, and testosterone) were checked. Lastly, PCOS cases were split into three subgroups based on IR centile to show the relationship between CCA and AUC.Results. There are strong inverse correlations between CCA-AUC versus HDL and SHBG (-0.98, -0.99), P < 0.0001. CCA-AUC correlated strongly and positively with [LDL, Cholesterol, LH/FSH, Serum Insulin, CCA-IMT, and HOMA-IR], r = (0.99,0.78,0.98,0.97,0.99,0.99) P< 0.0001. Sub-group analysis signified increased CCA-AUC with increasing IR severity (31.83 ± 3.90, 46.54 ± 5.03, 59.96 ± 2.57) P < 0.001; likewise, RI and PI of the CCA showed positive correlations (P = 0.040, P = 0.758) respectively. Conclusions.A strong correlation of CCA-AUC with all hormonals, biochemical, and biophysical changes among PCOS cases, in addition to its simplicity and accuracy, makes CCA-AUC a recommendable parameter in PCOS women for diagnostic and prognostic values.

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Cardiovascular Risk Factors and Subclinical Atherosclerosis in Greek Adolescents with Polycystic Ovary Syndrome: Its Relationship with Body Mass Index

Cited by 11 publications

References 46 publications

Prediction a woman having Polycystic Ovary Syndrome (PCOS) those having Insulin Resistance (IR)

Prediction a woman having Polycystic Ovary Syndrome (PCOS) those having Insulin Resistance (IR)

The Burden of Non-Alcoholic Fatty Liver Disease in Adolescents with Polycystic Ovary Syndrome: A Case–Control Study

Area Under the Curve of carotid artery Doppler as a sensitive marker of insulin sensitivity among Iraqi women with polycystic ovarian syndrome: a cross sectional study

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