Cardiovascular system participation in Alzheimer's disease pathogenesis

Roher, A. E.

doi:10.1111/joim.12311

Cited by 9 publications

(11 citation statements)

References 22 publications

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“…An increased in intracranial PI is an indicator of increased distal resistance to blood flow within the microvasculature which is often related to small vessel disease [85]. These results are in agreement with other studies that have used TCD to determine the effect of AD on blood flow to the brain [82].…”

Section: Alterations In 4dflow and Pulsatility Related To Dementiasupporting

confidence: 81%

“…There is increasing evidence that cerebral arteries are often morphologically altered and dysfunctional in Alzheimer's disease (AD) [82]. Cerebral blood flow, arterial pulsation and vasomotion are reduced in AD patients, and thus the normal perivascular transmission of metabolites out of the brain is diminished.…”

Section: Alterations In 4dflow and Pulsatility Related To Dementiamentioning

confidence: 99%

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Neurovascular 4DFlow MRI (Phase Contrast MRA): emerging clinical applications

et al. 2016

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Recent advances in 4DFlow MRI (Phase Contrast MRA) acquisition and reconstruction enable high resolution exams to be obtained in practical imaging times. 4DFlow MRI provides images of vascular morphology and quantitative measurements of blood velocity throughout a 3D imaging volume. Hemodynamic parameters such as flow volume, relative wall shear stress, streamlines, vorticity and pressure gradients can be derived from the velocity data. The combination of anatomic vessel wall imaging, lumen visualization and physiologic data derived from accelerated 4DFlow MRI augments the characterization of intracranial arterial stenosis, aneurysms, vascular malformations and dural sinus pathology. This review provides an update for clinicians interested in 4DFlow MRI of the brain.

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Section: Alterations In 4dflow and Pulsatility Related To Dementiasupporting

confidence: 81%

Section: Alterations In 4dflow and Pulsatility Related To Dementiamentioning

confidence: 99%

Neurovascular 4DFlow MRI (Phase Contrast MRA): emerging clinical applications

et al. 2016

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“…Increasing evidence exists indicating pathologic alterations of the cerebral vasculature in Alzheimer’s disease (AD) and dementia with Lewy bodies patients (3–6). In light of the mounting evidence, there is a necessity to assess the cerebrovascular network.…”

Section: Introductionmentioning

confidence: 99%

Comparison of ferumoxytol‐based cerebral blood volume estimates using quantitative R₁ and relaxometry

Rivera‐Rivera

Schubert

Knobloch

et al. 2017

Magnetic Resonance in Med

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“…[1][2][3] Cerebral blood flow, arterial pulsation, and vasomotion are reduced in AD patients, and thus the normal transmission of metabolites out of the brain is diminished. 4 Reduction in vascular elasticity and contractile force decrease the amplitude of the arterial pulse and slow the driving force for the perivascular clearance of interstitial fluid.…”

Section: Introductionmentioning

confidence: 99%

4D flow MRI for intracranial hemodynamics assessment in Alzheimer’s disease

Rivera‐Rivera

Turski

Johnson

et al. 2016

J Cereb Blood Flow Metab

121

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Cerebral blood flow, arterial pulsation, and vasomotion play important roles in the transport of waste metabolites out of the brain. Impaired vasomotion results in reduced driving force for the perivascular/glymphatic clearance of beta-amyloid. Noninvasive cerebrovascular characteristic features that potentially assess these transport mechanisms are mean blood flow (MBF) and pulsatility index (PI). In this study, 4D flow MRI was used to measure intra-cranial flow features, particularly MBF, PI, resistive index (RI) and cross-sectional area in patients with Alzheimer's disease (AD), mild cognitive impairment and in age matched and younger cognitively healthy controls. Three-hundred fourteen subjects participated in this study. Volumetric, time-resolved phase contrast (PC) MRI data were used to quantify hemodynamic parameters from 11 vessel segments. Anatomical variants of the Circle of Willis were also cataloged. The AD population reported a statistically significant decrease in MBF and cross-sectional area, and also an increase in PI and RI compared to age matched cognitively healthy control subjects. The 4D flow MRI technique used in this study provides quantitative measurements of intracranial vessel geometry and the velocity of flow. Cerebrovascular characteristics features of vascular health such as pulsatility index can be extracted from the 4D flow MRI data.

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Cardiovascular system participation in Alzheimer's disease pathogenesis

Cited by 9 publications

References 22 publications

Neurovascular 4DFlow MRI (Phase Contrast MRA): emerging clinical applications

Neurovascular 4DFlow MRI (Phase Contrast MRA): emerging clinical applications

Comparison of ferumoxytol‐based cerebral blood volume estimates using quantitative R₁ and relaxometry

4D flow MRI for intracranial hemodynamics assessment in Alzheimer’s disease

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Cardiovascular system participation in Alzheimer's disease pathogenesis

Cited by 9 publications

References 22 publications

Neurovascular 4DFlow MRI (Phase Contrast MRA): emerging clinical applications

Neurovascular 4DFlow MRI (Phase Contrast MRA): emerging clinical applications

Comparison of ferumoxytol‐based cerebral blood volume estimates using quantitative R1 and relaxometry

4D flow MRI for intracranial hemodynamics assessment in Alzheimer’s disease

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Comparison of ferumoxytol‐based cerebral blood volume estimates using quantitative R₁ and relaxometry