Cardiovascular toxicity and tissue proton T1 response to manganese injection in the dog and rabbit

Gl, Wolf; Baum, Larry

doi:10.2214/ajr.141.1.193

Cited by 147 publications

(93 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The authors suggest that all this may be due to the blocked slow channel and inhibited Ca 2+ influx by Mn (21). These and other experimental data on Mn cardiotoxicity are summarized in Table 1 (13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25).…”

Section: Effect Of Mn Exposure On Myocardial Contractionmentioning

confidence: 99%

See 1 more Smart Citation

Cardiovascular Toxicities Upon Manganese Exposure

Jiang

Zheng

2005

118

View full text Add to dashboard Cite

Manganese (Mn)-induced Parkinsonism has been well documented; however, little attention has been devoted to Mn-induced cardiovascular dysfunction. This review summarizes literature data from both animal and human studies on Mn's effect on cardiovascular function. Clinical and epidemiological evidence suggests that the incidence of abnormal electrocardiogram (ECG) is significantly higher in Mn-exposed workers than that in the control subjects. The main types of abnormal ECG include sinus tachycardia, sinus bradycardia, sinus arrhythmia, sinister megacardia, and ST-T changes. The accelerated heartbeat and shortened P-R interval appear to be more prominent in female exposed workers than in their male counterparts. Mn-exposed workers display a mean diastolic blood pressure that is significantly lower than that of the control subjects, especially in the young and female exposed workers. Animal studies indicate that Mn is capable of quickly accumulating in heart tissue, resulting in acute or sub-acute cardiovascular disorders, such as acute cardiodepression and hypotension. These toxic outcomes appear to be associated with Mn-induced mitochondrial damage and interaction with the calcium channel in the cardiovascular system.

show abstract

Section: Effect Of Mn Exposure On Myocardial Contractionmentioning

confidence: 99%

“…MnDPDP appears to be about 10 times less potent than MnCl 2 in eliciting these cardiovascular responses (35,36). Table 2 summarizes general experimental observations on Mn vascular effect (17,19,(22)(23)(24)(25)30).…”

Section: Effect Of Mn On Arginaseor Ca-mediated Vasoconstrictionmentioning

confidence: 99%

Cardiovascular Toxicities Upon Manganese Exposure

Jiang

Zheng

2005

118

View full text Add to dashboard Cite

show abstract

“…Only limited information is available regarding acute toxicity of Mn in dogs. Previously reported acute exposure studies in dogs (10,22) were limited to single intravenous doses of Mn at levels of 10-100 ~,mol/kg, which caused changes in cardiac electrophysiology and arterial blood pressure. Histomorphologic changes in the liver were characterized by severe periportal to massive hepatocellular necrosis, resulting in collapse of parenchymal architecture and periportal hemorrhages (Fig.…”

Section: Introductionmentioning

confidence: 99%

Toxicity of Subacute Intravenous Manganese Chloride Administration in Beagle Dogs

Khan¹,

Andress²,

Smith³

1997

Toxicol Pathol

View full text Add to dashboard Cite

“…The main discrepancy and limitation of MEMRI, however, is that separate groups of animals must be used for each stimulus, whereas during fMRI it is possible to present several different stimuli consecutively and alternately to the same animal. The use of manganese has therefore been limited to small animals because of concerns about toxicity, specifically acute cardiovascular depression (152), as it acts as a transient competitive antagonist to calcium activity, reducing contractility and systemic blood pressure. To date it has been approved for clinical imaging only in a chelated form: manganese dipyridoxyl diphosphate (153).…”

Section: Advantages and Disadvantages Of Different Fmri Methodsmentioning

confidence: 99%

Current status of functional MRI on small animals: application to physiology, pathophysiology, and cognition

et al. 2007

View full text Add to dashboard Cite

This review aims to make the reader aware of the potential of functional MRI (fMRI) in brain activation studies in small animal models. As small animals generally require anaesthesia for immobilization during MRI protocols, this is believed to be a serious limitation to the type of question that can be addressed with fMRI. We intend to introduce a fresh view with an in-depth overview of the surprising number of fMRI applications in a wide range of important research domains in neuroscience. These include the pathophysiology of brain functioning, the basic science of activity, and functional connectivity of different sensory circuits, including sensory brain mapping, the challenges when studying the hypothalamus as the major control centre in the central nervous system, and the limbic system as neural substrate for emotions and reward. Finally the contribution of small animal fMRI research to cognitive neuroscience is outlined. This review avoids focusing exclusively on traditional small laboratory animals such as rodents, but rather aims to broaden the scope by introducing alternative lissencephalic animal models such as songbirds and fish, as these are not yet well recognized as neuroimaging study subjects. These models are well established in many other neuroscience disciplines, and this review will show that their investigation with in vivo imaging tools will open new doors to cognitive neuroscience and the study of the autonomous nervous system in experimental animals.

show abstract

Cardiovascular toxicity and tissue proton T1 response to manganese injection in the dog and rabbit

Cited by 147 publications

References 20 publications

Cardiovascular Toxicities Upon Manganese Exposure

Cardiovascular Toxicities Upon Manganese Exposure

Toxicity of Subacute Intravenous Manganese Chloride Administration in Beagle Dogs

Current status of functional MRI on small animals: application to physiology, pathophysiology, and cognition

Contact Info

Product

Resources

About