“…10,11 For the future, use of more homogeneous outcomes for pain studies as well as control for procedure type could help in the development of more effective protocols to relieve pain during the wait for new agents. Additionally, in 2014, manufacturers will also have to add a boxed warning to the label of products with acetaminophen to reduce the incidence of liver failure, need for liver transplantation, and death from unintentional overdose.…”