Carnitine palmitoyl transferase I: Conformational changes induced by long-chain fatty acyl CoA ligands

The evolution of small molecule enzyme activators

“…51,52 CPT1 is considered as the rate controlling enzyme for the CPT system and the FAO cycle. 53–55 Therefore, the activation of CPT1 has been identified as a mechanism to promote FAO, which results in the reduction of lipid accumulation and a decreased tendency for metabolic disorders. 56,57…”