Carotenoid composition and conformation in retinal oil droplets of the domestic chicken*

Arteni, Ana-Andreea; LaFountain, Amy M.; Alexandre, Maxime; Fradot, Mathias; Mendes-Pinto, Maria Manuela; Sahel, José‐Alain; Picaud, Serge; Frank, Harry A.; Robert, Bruno; Pascal, Andrew A.

doi:10.1371/journal.pone.0217418

Cited by 6 publications

(4 citation statements)

References 19 publications

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“…Mixed bands of lipids and proteins and proteins and nucleic acids can be seen at 1,337 and 935 cm −1 , respectively. In the mean spectrum, the characteristic spectral pattern of carotenoids can be observed at 1,523, 1,160, and 1,007 cm −1 ( 29 , 31 ) that represent the most prominent peaks in the difference spectrum. These signals derive mainly from the carotenoid staphyloxanthin, the characteristic golden pigment of S. aureus present in the majority of the strains of this species ( 32 , 33 ).…”

Section: Resultsmentioning

confidence: 99%

Comparison of Different Label-Free Raman Spectroscopy Approaches for the Discrimination of Clinical MRSA and MSSA Isolates

et al. 2022

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Section: Resultsmentioning

confidence: 99%

Comparison of Different Label-Free Raman Spectroscopy Approaches for the Discrimination of Clinical MRSA and MSSA Isolates

et al. 2022

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“…In photosynthetic organisms and tissues, the lipophilic carotenoid and bacteriochlorophyll (Bchl) or chlorophyll (Chl) pigment molecules associate non-covalently, but specifically, with integral membrane proteins. In non-photosynthetic organisms and tissues, carotenoids, often protein-bound, occur in cytoplasmic or cell wall membranes, oil droplets, crystals, and fibrils [16,30,31].…”

Section: Reconstruction Of a Metabolic Map For Global Carotenogenesismentioning

confidence: 99%

Deciphering Pathways for Carotenogenesis in Haloarchaea

et al. 2020

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Bacterioruberin and its derivatives have been described as the major carotenoids produced by haloarchaea (halophilic microbes belonging to the Archaea domain). Recently, different works have revealed that some haloarchaea synthetize other carotenoids at very low concentrations, like lycopene, lycopersene, cis- and trans-phytoene, cis- and trans-phytofluene, neo-β-carotene, and neo-α-carotene. However, there is still controversy about the nature of the pathways for carotenogenesis in haloarchaea. During the last decade, the number of haloarchaeal genomes fully sequenced and assembled has increased significantly. Although some of these genomes are not fully annotated, and many others are drafts, this information provides a new approach to exploring the capability of haloarchaea to produce carotenoids. This work conducts a deeply bioinformatic analysis to establish a hypothetical metabolic map connecting all the potential pathways involved in carotenogenesis in haloarchaea. Special interest has been focused on the synthesis of bacterioruberin in members of the Haloferax genus. The main finding is that in almost all the genus analyzed, a functioning alternative mevalonic acid (MVA) pathway provides isopentenyl pyrophosphate (IPP) in haloarchaea. Then, the main branch to synthesized carotenoids proceeds up to lycopene from which β-carotene or bacterioruberin (and its precursors: monoanhydrobacterioriberin, bisanhydrobacterioruberin, dihydrobisanhydrobacteriuberin, isopentenyldehydrorhodopsin, and dihydroisopenthenyldehydrorhodopsin) can be made.

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“…[ 7 ] In bird and turtle retinas, carotenoids are concentrated in oil droplets and color tune the absorption spectra of the adjacent cone photoreceptors. [ 8–10 ]…”

Section: Introductionmentioning

confidence: 99%

Aster la vista: Unraveling the biochemical basis of carotenoid homeostasis in the human retina

Bandara

Lintig

2022

BioEssays

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Carotenoids play pivotal roles in vision as light filters and precursor of chromophore.Many vertebrates also display the colorful pigments as ornaments in bare skin parts and feathers. Proteins involved in the transport and metabolism of these lipids have been identified including class B scavenger receptors and carotenoid cleavage dioxygenases. Recent research implicates members of the Aster protein family, also known as GRAM domain-containing (GRAMD), in carotenoid metabolism. These multi-domain proteins facilitate the intracellular movement of carotenoids from their site of cellular uptake by scavenger receptors to the site of their metabolic processing by carotenoid cleavage dioxygenases. We provide a model how the coordinated interplay of these proteins and their differential expression establishes carotenoid distribution patterns and function in tissues, with particular emphasis on the human retina.

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Carotenoid composition and conformation in retinal oil droplets of the domestic chicken*

Cited by 6 publications

References 19 publications

Comparison of Different Label-Free Raman Spectroscopy Approaches for the Discrimination of Clinical MRSA and MSSA Isolates

Comparison of Different Label-Free Raman Spectroscopy Approaches for the Discrimination of Clinical MRSA and MSSA Isolates

Deciphering Pathways for Carotenogenesis in Haloarchaea

Aster la vista: Unraveling the biochemical basis of carotenoid homeostasis in the human retina

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