Carotenoids as Anticancer Agents

Dewanjee, Saikat; Das, Sonjit; Joardar, Swarnalata; Bhattacharjee, Surajit; Chakraborty, Pratik

doi:10.1007/978-3-030-46459-2_13

Cited by 6 publications

(5 citation statements)

References 144 publications

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“…OS is regarded as one of the key contributors to disturb brain homeostasis and is involved in carcinogenesis of different types of brain cancers [49]. Thus, antioxidants may act as tumor-growth suppressors by preventing OS caused by different oncogenic factors [135,184,196,197,207,212]. Antioxidants negatively influence cancer initiation by endorsing DNA repair.…”

Section: Discussion and Future Perspectivesmentioning

confidence: 99%

“…Carotenoids are a class of naturally occurring dietary antioxidants with significant chemopreventive and chemotherapeutic potential in different types of cancers including CNS tumors. Carotenoids exhibit chemopreventive effects by suppressing the harmful effects of free radicals that regulate cancer cell proliferation, cell cycle progression, invasion, inflammation, and angiogenesis by regulating several molecular events including Akt/ PI3K/mTOR, cyclin/cyclin-dependent kinase (CDK), PPAR, Wnt, VEGF, MMPs, and NF-κB signaling [207]. Like other antioxidants, carotenoids can also promote ROS production with prooxidant chemistry that aid in their chemotherapeutic potential.…”

Section: Other Naturally Occurring Antioxidants In Brain Tumor Manage...mentioning

confidence: 99%

“…Mutation of PTEN is evident in glioblastoma cells [267]. Vitamin E, carotenoids, curcumin, resveratrol, genistein, xanthohumol, and garlic-derived organosulfides can suppress Akt activation via phosphorylation [107,133,158,205,207,222,223]. Different antioxidants, such as epigallocatechin gallate, genistein, carotenoids, resveratrol, stilbenes etc.…”

Section: Effect Of Antioxidants On Gene Mutation In Brain Cancermentioning

confidence: 99%

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Antioxidants in brain tumors: current therapeutic significance and future prospects

Jha

et al. 2022

Mol Cancer

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Brain cancer is regarded among the deadliest forms of cancer worldwide. The distinct tumor microenvironment and inherent characteristics of brain tumor cells virtually render them resistant to the majority of conventional and advanced therapies. Oxidative stress (OS) is a key disruptor of normal brain homeostasis and is involved in carcinogenesis of different forms of brain cancers. Thus, antioxidants may inhibit tumorigenesis by preventing OS induced by various oncogenic factors. Antioxidants are hypothesized to inhibit cancer initiation by endorsing DNA repair and suppressing cancer progression by creating an energy crisis for preneoplastic cells, resulting in antiproliferative effects. These effects are referred to as chemopreventive effects mediated by an antioxidant mechanism. In addition, antioxidants minimize chemotherapy-induced nonspecific organ toxicity and prolong survival. Antioxidants also support the prooxidant chemistry that demonstrate chemotherapeutic potential, particularly at high or pharmacological doses and trigger OS by promoting free radical production, which is essential for activating cell death pathways. A growing body of evidence also revealed the roles of exogenous antioxidants as adjuvants and their ability to reverse chemoresistance. In this review, we explain the influences of different exogenous and endogenous antioxidants on brain cancers with reference to their chemopreventive and chemotherapeutic roles. The role of antioxidants on metabolic reprogramming and their influence on downstream signaling events induced by tumor suppressor gene mutations are critically discussed. Finally, the review hypothesized that both pro- and antioxidant roles are involved in the anticancer mechanisms of the antioxidant molecules by killing neoplastic cells and inhibiting tumor recurrence followed by conventional cancer treatments. The requirements of pro- and antioxidant effects of exogenous antioxidants in brain tumor treatment under different conditions are critically discussed along with the reasons behind the conflicting outcomes in different reports. Finally, we also mention the influencing factors that regulate the pharmacology of the exogenous antioxidants in brain cancer treatment. In conclusion, to achieve consistent clinical outcomes with antioxidant treatments in brain cancers, rigorous mechanistic studies are required with respect to the types, forms, and stages of brain tumors. The concomitant treatment regimens also need adequate consideration.

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Section: Discussion and Future Perspectivesmentioning

confidence: 99%

Section: Other Naturally Occurring Antioxidants In Brain Tumor Manage...mentioning

confidence: 99%

Section: Effect Of Antioxidants On Gene Mutation In Brain Cancermentioning

confidence: 99%

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Antioxidants in brain tumors: current therapeutic significance and future prospects

Jha

et al. 2022

Mol Cancer

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“…Carotenoids are a class of natural antioxidants which can have chemo preventive and chemotherapeutical properties in different types of cancers, including the CNS ones. Their mechanism of action is based on the suppression of the damaging effects of the free radicals that can regulate cell proliferation, cell cycle progression, invasion, inflammation (Dewanjee et al, 2021). Crocetin showed chemo preventive effects on glioblastoma cells, inhibiting proliferation, and inducing morphology changes.…”

Section: Potential Therapeutic Effects Of Saffron In Brain Tumoursmentioning

confidence: 99%

Therapeutic potential of saffron in brain disorders: From bench to bedside

Bej,

Volpe,

Cesare

et al. 2024

Phytotherapy Research

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Saffron is a spice derived from the flower of Crocus sativus L., which has been used for centuries as a coloring and flavoring agent, as well as a source of medicinal compounds. Saffron contains various bioactive constituents, such as crocin, crocetin, safranal, picrocrocin, and kaempferol, that have shown potential benefits for human health. Among them, crocin is the most abundant and characteristic constituent of saffron, responsible for its bright red color and antioxidant properties. One of the most promising applications of saffron and its constituents is in the prevention and treatment of neurological disorders, such as depression, anxiety, Alzheimer's disease, Parkinson's disease, and other brain disorders. Saffron and its constituents have been reported to exert neuroprotective effects through various mechanisms, such as modulating neurotransmitters, enhancing neurogenesis, reducing neuroinflammation, regulating oxidative stress, activating the Nrf2 signaling pathway, and modulating epigenetic factors. Several clinical and preclinical studies have demonstrated the efficacy and safety of saffron and its constituents in improving cognitive function, mood, and other neurological outcomes. In this review, we summarize the current evidence on the therapeutic potential of saffron and its constituents in neurological disorders, from bench to bedside. We also discuss the challenges and future directions for the development of saffron‐based therapies for brain health.

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“…Chemoprevention is another approach that is widely practiced worldwide, and it is useful during the initiation phase of carcinogenesis, while some have even reported its effectiveness in the promotion and progression phases too [32]. The chemopreventive agents are generally classified into two principal categories, where one group includes blocking agents, while others are suppressive agents majorly sourced from plant phytochemicals [33]. Blocking agents work uniquely; they suppress the carcinogen activation through the metabolic pathway and do not allow carcinogenic agents to interact with the biomolecule.…”

Section: Development Of Cancer and Phytochemical Pathways Of Actionmentioning

confidence: 99%

Exploring the Phytochemicals and Anti-Cancer Potential of the Members of Fabaceae Family: A Comprehensive Review

et al. 2022

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Cancer is the second-ranked disease and a cause of death for millions of people around the world despite many kinds of available treatments. Phytochemicals are considered a vital source of cancer-inhibiting drugs and utilize specific mechanisms including carcinogen inactivation, the induction of cell cycle arrest, anti-oxidant stress, apoptosis, and regulation of the immune system. Family Fabaceae is the second most diverse family in the plant kingdom, and species of the family are widely distributed across the world. The species of the Fabaceae family are rich in phytochemicals (flavonoids, lectins, saponins, alkaloids, carotenoids, and phenolic acids), which exhibit a variety of health benefits, especially anti-cancer properties; therefore, exploration of the phytochemicals present in various members of this family is crucial. These phytochemicals of the Fabaceae family have not been explored in a better way yet; therefore, this review is an effort to summarize all the possible information related to the phytochemical status of the Fabaceae family and their anti-cancer properties. Moreover, various research gaps have been identified with directions for future research.

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Carotenoids as Anticancer Agents

Cited by 6 publications

References 144 publications

Antioxidants in brain tumors: current therapeutic significance and future prospects

Antioxidants in brain tumors: current therapeutic significance and future prospects

Therapeutic potential of saffron in brain disorders: From bench to bedside

Exploring the Phytochemicals and Anti-Cancer Potential of the Members of Fabaceae Family: A Comprehensive Review

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