Carotid inter‐adventitial diameter is more strongly related to plaque score than lumen diameter: An automated tool for stroke analysis

Saba, Luca; Araki, Tadashi; Kumar, Pankaj; Rajan, Jeny; Lavra, Francesco; Ikeda, Nobutaka; Sharma, Aditya; Shafique, Shoaib; Nicolaides, Andrew; Laird, John R.; Gupta, Ajay; Suri, Jasjit S.

doi:10.1002/jcu.22334

Cited by 28 publications

(15 citation statements)

References 46 publications

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“…The common carotid interadventitial diameter (IAD) can be easily measured as well as carotid IMT by using carotid ultrasonography. It is associated with vascular risk factors, carotid IMT, plaque scores, left ventricular mass, and myocardial infarction 26 , 101 – 103 ) . It was reported that the presence of both increased IAD, and increased IMT was the strongest predictor of stroke incidence in the general population 104 ) .…”

Section: Other Aspects Of Assessments Using Carotid Ultrasonographmentioning

confidence: 99%

Usefulness of Carotid Ultrasonography for Risk Stratification of Cerebral and Cardiovascular Disease

Nezu

Hosomi

2020

JAT

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Carotid ultrasonography is useful for the assessments of the risk stratification for stroke or coronary artery disease, because it is a simple, repeatable, and noninvasive procedure. The carotid intima-media thickness (IMT), which is assessed using carotid ultrasonography, is a widely used surrogate marker for the severity of atherosclerosis. Several large clinical studies showed that increased carotid IMT is associated with the future stroke or cardiovascular events. In addition, in many clinical trials, it has been adopted for surrogate markers of clinical endpoints of medical intervention. Moreover, carotid ultrasonography allows the measurement of the presence and characteristics of plaques and the severity of carotid artery stenosis. The unstable morphology of plaque, such as hypoechoic, ulcer, and mobility, is associated with future ischemic stroke events. The screening tool of asymptomatic carotid artery stenosis is also important, although whether routine carotid ultrasonography assessment is recommended in the general population remains controversial. The screening of carotid artery stenosis using ultrasonography is essential for not only daily clinical settings but also management of patients with acute ischemic stroke. The patients with atherothrombotic stroke with severe internal carotid artery stenosis should be considered to surgical intervention, and duplex ultrasound approach is important to estimate for the severity of carotid stenosis. Physicians should keep in mind the usefulness of carotid ultrasonography for risk stratification of cerebral and cardiovascular disease based on various aspects. In addition, visual assessment or dynamic changes using carotid ultrasonography could provide the various and valuable insights in clinical settings.

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Section: Other Aspects Of Assessments Using Carotid Ultrasonographmentioning

confidence: 99%

Usefulness of Carotid Ultrasonography for Risk Stratification of Cerebral and Cardiovascular Disease

Nezu

Hosomi

2020

JAT

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“…Current systems are not fully automated 30 and lack advanced image-based features for risk assessment. 31,32 Often, these systems lack reliability, accuracy, reproducibility, and provide no comparative reference marker needed for monitoring. Furthermore, there is no standardization towards clinical trials.…”

Section: Introductionmentioning

confidence: 99%

Accurate cloud-based smart IMT measurement, its validation and stroke risk stratification in carotid ultrasound: A web-based point-of-care tool for multicenter clinical trial

Saba

Banchhor

Suri³

et al. 2016

Computers in Biology and Medicine

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“…Saba et al found that the correlation between AD and plaque score throughout the CCA, ICA, and bulb segments was 0.38 in a Japanese population. 54 The mechanisms affecting this measure of vascular remodeling during the menopause transition may be due to other factors such as endogenous hormones E2 and FSH, which dramatically change in the years surrounding the final menstrual period. 55 In the extended models in which we considered potential intermediate factors, we further adjusted for SBP, hsCRP, tPA, and PAI-1, and the effect size did not change appreciably.…”

Section: Discussionmentioning

confidence: 99%

Residential Exposure to PM_2.5 and Ozone and Progression of Subclinical Atherosclerosis Among Women Transitioning Through Menopause: The Study of Women's Health Across the Nation

Duan

Talbott

Broadwin

et al. 2019

Journal of Women's Health

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Objective: This article aims to examine the association between long-term ambient air pollution and progression of subclinical atherosclerosis with 2-year follow-up among midlife women from the Study of Women's Health Across the Nation (SWAN). Materials and Methods: Carotid duplex ultrasonography was performed in participants from a SWAN ancillary study carried out at the Pittsburgh and Chicago sites. Mean and maximum carotid intima-media thickness (CIMT) and plaque burden were assessed throughout the common, bulb, and internal carotid artery. The yearly mean exposure to PM 2.5 (particulate matter) and ozone was generated based on monitors within 20 km of the participants' home. The effect of air pollutants during follow-up on progression of CIMT was estimated using linear mixed-effects models, and the effect on progression of plaque presence and plaque index, a measure of extent of plaque, was evaluated using logistic regression. Results: This study included 417 (257 White and 160 Black) women with a mean age of 51 years at baseline. A 1 lg/m 3 higher yearly mean exposure to PM 2.5 during follow-up was associated with a 4.28 (95% confidence interval [CI]: 0.02-8.54) lm/year increase in maximum CIMT, after adjusting for socioeconomic and traditional cardiovascular disease (CVD) risk factors. Exposure to PM 2.5 contributed to a 30% (95% CI: 3%-65%) higher odds of plaque index progression adjusting for socioeconomic factors only. Conclusions: PM 2.5 independently contributed to progression of subclinical atherosclerosis, among women transitioning through menopause, a time of increasing CVD risk. Yet no significant associations between ozone and subclinical atherosclerosis were observed.

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Carotid inter‐adventitial diameter is more strongly related to plaque score than lumen diameter: An automated tool for stroke analysis

Abstract: Our automated measurement system gave satisfying results in comparison with manual measurements. Carotid IAD was more strongly correlated to PS than carotid LD in this population sample of Japanese diabetic patients.

Cited by 28 publications

References 46 publications

Usefulness of Carotid Ultrasonography for Risk Stratification of Cerebral and Cardiovascular Disease

Usefulness of Carotid Ultrasonography for Risk Stratification of Cerebral and Cardiovascular Disease

Accurate cloud-based smart IMT measurement, its validation and stroke risk stratification in carotid ultrasound: A web-based point-of-care tool for multicenter clinical trial

Residential Exposure to PM_2.5 and Ozone and Progression of Subclinical Atherosclerosis Among Women Transitioning Through Menopause: The Study of Women's Health Across the Nation

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Carotid inter‐adventitial diameter is more strongly related to plaque score than lumen diameter: An automated tool for stroke analysis

Abstract: Our automated measurement system gave satisfying results in comparison with manual measurements. Carotid IAD was more strongly correlated to PS than carotid LD in this population sample of Japanese diabetic patients.

Cited by 28 publications

References 46 publications

Usefulness of Carotid Ultrasonography for Risk Stratification of Cerebral and Cardiovascular Disease

Usefulness of Carotid Ultrasonography for Risk Stratification of Cerebral and Cardiovascular Disease

Accurate cloud-based smart IMT measurement, its validation and stroke risk stratification in carotid ultrasound: A web-based point-of-care tool for multicenter clinical trial

Residential Exposure to PM2.5 and Ozone and Progression of Subclinical Atherosclerosis Among Women Transitioning Through Menopause: The Study of Women's Health Across the Nation

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Residential Exposure to PM_2.5 and Ozone and Progression of Subclinical Atherosclerosis Among Women Transitioning Through Menopause: The Study of Women's Health Across the Nation