Carotid intima media thickness can predict coronary artery disease

Balta, Şevket; Aparcı, Mustafa; Öztürk, Cengiz; Ünlü, Murat; Çelik, Turgay

doi:10.1016/j.ijcard.2014.10.100

Cited by 12 publications

(8 citation statements)

References 5 publications

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“…Atheroma, which develops due to the accumulation of the cholesterol crystals in the inner layers of the atherosclerotic arteries, causes the narrowing and blockage of the lumen. Systemic inflammation, increased oxidative stress, and alteration in the lipid profile are important in the development and the progression of the process [5,10,18]. There are studies in which the TG and HDL and the ratio of TG and HDL can be used to calculate the PAI.…”

Section: Discussionmentioning

confidence: 99%

Plasma Atherogenic Index is an Independent Indicator of Subclinical Atherosclerosis in Systemic Lupus Erythematosus

et al. 2017

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Objective: Systemic lupus erythematosus (SLE) is characterized by chronic inflammation. Plasma atherogenic index (PAI) is a valuable marker for the cardiovascular disease and cardiac risk. The aim of this study was to evaluate the role and clinical use of PAI in atherosclerosis and the cardiac risk in SLE patients. Materials and Methods:We included 56 female SLE patients who were selected according to the American College of Rheumatology (1997) diagnosis criteria. Furthermore, we selected age-and body mass index (BMI)-matched 56 female healthy individuals. PAI was measured as a logarithmic value of triglyceride to high-density cholesterol ratio. We used carotid intima media thickness (cIMT) as an inflammatory marker because of its widespread use. The lipid and other biochemical parameters of patient and control groups were examined.Results: The PAI and cIMT values of SLE patients were 0.04±0.23 and 0.78±0.18 mm, respectively. Besides, for the control group, the PAI value was −0.09±0.20 and cIMT value was 0.50±0.15 mm (p=0.002, p<0.001; respectively). There was a strong correlation between cIMT and PAI (r=0.273, p=0.003). According to the multiple logistic regression analysis, we found that PAI value is an independent factor for cIMT in SLE patients (odds ratio: 2.6, 95 % confidence interval; 1.506-4.374; p=0.029). Conclusions:We determined that PAI can be used as an independent indicator for subclinical atherosclerosis in SLE patients.Keywords: Plasma atherogenic index, carotid intima-media thickness, systemic lupus erythematosus, atherosclerosis ÖZ Amaç: Sistemik lupus eritematozus (SLE), kronik inflamasyon ile karakterize bir hastalıktır. Plazma aterojenik indeks (PAI), kardiyovasküler hastalık ve kardiyak risk için değerli bir belirteçtir. Bu çalışmanın amacı PAI'in SLE hastalarında aterosklerozu ve kardiyak riski değerlendirmekteki rolü ve klinik kullanılabilirliliğini araştırmaktır.Gereç ve Yöntem: Amerikan Romatoloji Koleji (1997) tanı kriterlerine göre değerlendirilen 56 kadın SLE hastası dahil edildi. Ayrıca yaş ve vucüt kitle indeksi uyumlu 56 kadın sağlıklı kişi seçildi. PAI, trigliserit'in yüksek yoğunluklu kolesterole oranı logartimik ölçümüdür. Karotis intima medya kalınlığı (KIMK) inflamatuvar belirteç olarak yaygın olarak kullanıldığından, bu işareti bu çalışmada kullandık. Hasta ve kontrol gruplarının lipid ve diğer biyokimyasal parametreleri incelendi.Bulgular: Hasta grubunda PAI 0,04±0,23, KIMK 0,78±0,18 mm, kontrol grubunda PAI -0,09±0,20, KIMK 0,50±0,15 mm olduğu tespit edildi. Hasta grubunda PAI ve KIMK'ın kontrol grubuna kıyasla yüksek olduğu görüldü (sırasıyla p=0,002, p<0,001). SLE hastaları içerisine KIMK ile PAI arasında pozitif korelasyon olduğu görüldü (r=0,273, p=0,003). Multipl logistik regresyon analize göre PAI, KIMK için bağımsız risk faktörü olarak değerlendirildi (Olasılık oranı: 2,6, Güven aralığı %95 1,506-4,374, p=0,029).Sonuç: Bu çalışma bize PAI'nın SLE hastalarında subklinik aterosklerozun değerlendirilmesinde kullanılabilecek bağımsız bir belirteç olabileceğini d...

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Section: Discussionmentioning

confidence: 99%

Plasma Atherogenic Index is an Independent Indicator of Subclinical Atherosclerosis in Systemic Lupus Erythematosus

et al. 2017

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“…Thus, CIMT may be used as a predictor of AS [30]. In some other studies CIMT was also found to be associated with CADs [31]. However, these studies are done in the western world most of the time.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic accuracy of carotid intima media thickness by B-mode ultrasonography in coronary artery disease patients

Zaidi

Gilani

Mehboob

et al. 2020

Arch Med Sci Atheroscler Dis

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Introduction: Cardiovascular diseases (CVD) are the main cause of premature deaths worldwide, and atherosclerosis (AS) is a major risk factor associated with them. B-mode ultrasound is a well-validated research tool that has been translated increasingly into clinical practice. The aim of the study was to assess the diagnostic accuracy of carotid intima media thickness by B-mode ultrasonography in coronary artery disease patients. Material and methods: This was a case control study, including 100 cases and the same number of controls. Patients with positive angiographic findings and chest pain were considered as cases and those without as negative. Duplex carotid ultrasound was used to detect intima-media thickness (IMT). B-mode real-time ultrasonic images were obtained with a 7 MHz transducer. An intima media thickness of 0.6 mm was considered as being without plaque. Results: The angiographic findings were single-vessel disease, double-vessel disease, and triple-vessel disease in 18%, 11.5%, and 20.5% of cases, respectively, while there were no findings in controls. There was plaque formation in 14.5% and calcification in 12% of the cases. Sensitivity of B-mode ultrasonography was found to be 78%, specificity 75%, positive predictive value 75.72%, and negative predictive value 77.31%. Conclusions: Carotid ultrasonography can be utilised as a valuable screening tool due to having several advantages, including ease of application, reproducibility, low cost, and strong correlation with atherosclerosis.

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“…More recently, intima-media thickness (IMT) of the common carotid artery has been suggested as quick, non-invasive, and reproducible marker for CAD [4][5][6][7]. IMT is usually assessed by quantifying the distance between the echogenic media-adventitia layer and the echogenic lumenintima layer with B-mode ultrasound images [8].…”

Section: Introductionmentioning

confidence: 99%

Diagnostic Role of Carotid Intima-Media Thickness for Coronary Artery Disease: A Meta-Analysis

Liu

Shao

et al. 2020

BioMed Research International

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Background. The present meta-analysis was conducted to confirm whether carotid intima-media thickness (IMT) could serve as an accurate diagnostic method for coronary artery disease (CAD). Methods. Databases of PubMed, Google Scholar, and Embase were searched for potential articles. The articles were selected according to inclusion criteria. Pooled sensitivity and specificity with corresponding 95% confidence interval (CI) were used to confirm the diagnostic role of IMT for CAD. I2 and P value were used to assess the existence of heterogeneity. I2≥50% or P<0.05 indicated significant heterogeneity. Area under the curve (AUC) of summary receiver operating characteristics (SROC) represented the diagnostic accuracy of IMT. Sensitivity analysis was performed to evaluate the robustness of pooled outcomes. Deek’s funnel plot was drawn to detect potential publication bias. Results. 22 eligible articles were selected in the present meta-analysis. Pooled sensitivity and specificity of IMT for diagnosing CAD were 0.68 (0.57–0.77) and 0.70 (0.64–0.75), respectively. The corresponding AUC was 0.74 (0.70–0.78). Subgroup analyses based on cutoff value of IMT were performed. A cutoff value of 1 mm was demonstrated to be much more accurate diagnostic criteria for CAD (sensitivity: 0.66; specificity: 0.79; AUC: 0.80). Sensitivity analysis indicated that the pooled results were robust. Deek’s funnel plot indicated no significant publication bias (P=0.195). Conclusion. Carotid IMT may serve as an accurate diagnostic tool. A cutoff value of 1 mm seems to provide much more accurate diagnostic results for CAD.

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Carotid intima media thickness can predict coronary artery disease

Cited by 12 publications

References 5 publications

Plasma Atherogenic Index is an Independent Indicator of Subclinical Atherosclerosis in Systemic Lupus Erythematosus

Plasma Atherogenic Index is an Independent Indicator of Subclinical Atherosclerosis in Systemic Lupus Erythematosus

Diagnostic accuracy of carotid intima media thickness by B-mode ultrasonography in coronary artery disease patients

Diagnostic Role of Carotid Intima-Media Thickness for Coronary Artery Disease: A Meta-Analysis

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