Carotid intima-media thickness is a novel predictor of new onset of hypertension in normotensive subjects

Takase, Hiroyuki; Sugiura, Tonomori; Murai, Shunsuke; Yamashita, Sumiyo; Ohte, Nobuyuki; Dohi, Yasuaki

doi:10.1097/md.0000000000007710

Cited by 17 publications

(10 citation statements)

References 19 publications

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“…Being consistent with our findings, meta-analysis of Liu et al including 16 studies with 41 931 adults has shown that TC, LDL-C, and TG levels were significantly increased and HDL-C level was not significantly different in SCH patients compared with EU individuals [61]. In addition, hypertension is strongly associated with endothelial function and C-IMT can predict the development of hypertension [62]. Noisy living environment contribute to the prevalence of hypertension [63].…”

Section: Publication Bias Evaluationsupporting

confidence: 92%

Endothelial Function in Patients with Subclinical Hypothyroidism: A Meta-Analysis

et al. 2019

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The purpose of this meta-analysis was to determine whether patients with subclinical hypothyroidism (SCH) have impaired endothelial function, which is assessed by carotid intima-media thickness (C-IMT) and flow-mediated dilatation (FMD) of brachial artery. PubMed, Embase and Cochrane Library databases and the key studies references were searched in our study, prior to July 2017 for all language articles about FMD or C-IMT in SCH and euthyroid subjects. Two authors screened documents and extracted data by pre-established standard independently. The pooled estimate for continuous data was calculated using random-effects models. Statistical heterogeneity was evaluated using I2 statistics. Subgroup analyses were conducted to assess the robustness of the meta-analysis. Publication bias was examined with funnel plot analysis and Egger’s test. In this meta-analysis, 10 studies with 760 subjects are related to FMD with SCH and 23 studies with 1521 subjects are related to C-IMT with SCH. The pooled estimate of the weighted mean difference (WMD) has revealed that SCH correlated with increased C-IMT [WMD 0.069 mm; 95% CI (0.042, 0.095); p<0.001] and decreased FMD [WMD −1.848%; 95% CI (−2.298, −1.399); p<0.001] with high heterogeneity. Compared with EU controls, SCH was also associated with an increased diastolic blood pressure (DBP), systolic blood pressure (SBP), triglyceride (TG), total cholesterol (TC) levels, and low density lipoprotein cholesterol (LDL-C). This meta-analysis demonstrates that SCH is associated with endothelial dysfunction, which may relate with increased thyroid-stimulating hormone (TSH). Hypertension and dyslipidemia may play a crucial part in the development of endothelial dysfunction.

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Section: Publication Bias Evaluationsupporting

confidence: 92%

Endothelial Function in Patients with Subclinical Hypothyroidism: A Meta-Analysis

et al. 2019

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“…Subgroup results of studies found that the sources of high heterogeneity were not age and sample size. In the past few decades, a large number of studies have described the deep relationship between hypertension and CIMT, and hypertension patients usually have a higher CIMT [32][33][34]. However, the results of our subgroup analysis showed that CIMT was increased in both patients and controls with hypertension and the general population.…”

Section: Discussioncontrasting

confidence: 66%

Carotid intima-media thickness in patients with hyperuricemia: a systematic review and meta-analysis

Peng

et al. 2021

Aging Clin Exp Res

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Objective Despite the high incidence and mortality of cardiovascular events in hyperuricemia patients, the role of serum uric acid in cardiovascular diseases is still controversial. The aim of this meta-analysis was to explore the difference of carotid intima-media thickness in hyperuricemia and control groups. Methods We performed this meta-analysis by searching the PubMed, Cochrane Library, Embase and Web of Science databases up to July 2020. The 95% confidence intervals and standard mean differences were calculated to analyze the differences in carotid intima-media thickness in hyperuricemia groups and control groups. Sensitivity analysis, subgroup analysis and meta-regression were used to explore the sources of heterogeneity. Publication bias was evaluated by funnel plot and Begg's regression test. We used Stata 14.0 software to complete our analyses. Results A total of 8 articles were included. The results showed that there was a significant increase in carotid intima-media thickness in the hyperuricemia groups compared with the control groups [SMD = 0.264, 95% CI (0.161-0.366), P < 0.001]. Subgroup analyses showed that age, sample size, blood pressure and body mass index were not the source of heterogeneity. Meta-regression enrolled the method of CIMT measurement, location, age, smoking and diabetes mellitus as categorical variables, but none of these factors was found to be significant in the model. The Begg's test value (P = 0.174) was greater than 0.05, indicating there was no publication bias. ConclusionThe results showed that carotid intima-media thickness was increased in hyperuricemia patients compared with controls, which indicated that hyperuricemia patients may have a higher risk of cardiovascular diseases.

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“…Atherosclerosis examinations are widely performed, and CAVI and carotid IMT are representatives of functional and morphological assessments in large muscular and elastic arteries [17][18][19][20][21][22][23] . The usefulness of atherosclerotic examinations has been established not only in individuals with progressive atherosclerosis in clinical settings, but also in the asymptomatic general population at health check-ups 19,20,23,[32][33][34][35] . The ability to detect subclinical atherosclerosis in asymptomatic individuals is not so great with a single examination, though it could be improved by combining the examinations.…”

Section: Advance Publication Journal Of Atherosclerosis and Thrombosismentioning

confidence: 99%

Examination of Large Artery Atherosclerosis could Reveal Small Artery Retinopathy in Untreated Middle-Aged Individuals

Sugiura

Dohi

Takagi

et al. 2022

JAT

Self Cite

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Small arteries can be visualized in the ocular fundus, and findings of retinopathy based on Scheie classification are often applied to evaluate the impact of hypertension and atherosclerosis. However, the relationship between damage in the large and small arteries has not been investigated sufficiently, especially in the early stages. The present study investigated possible associations between large artery atherosclerosis and small artery retinopathy in untreated middle-aged individuals. Methods: Untreated middle-aged workers undergoing periodic health checkups (n 7,730, 45 8 years) were enrolled in this study. The absence or presence and extent of retinopathy were characterized by ophthalmologists as hypertensive (H0-4) and atherosclerotic grades (S0-4) based on Scheie classification. Large artery atherosclerosis was examined based on functional assessment of the cardio-ankle vascular index (CAVI) and morphological assessment of the carotid intima-media thickness (IMT) by ultrasound. Results: We found significant differences in CAVI and carotid IMT between individuals with and without hypertensive or atherosclerotic retinopathy. Multivariable regression analysis showed that the presence of hypertensive and atherosclerotic retinopathy was significantly associated with CAVI and carotid IMT. Logistic regression analysis with the endpoint of a hypertensive or atherosclerotic lesion revealed that CAVI and carotid IMT are independent determinants of retinopathy. Conclusions: CAVI and carotid IMT were significantly associated with the presence of retinopathy based on Scheie classification in untreated middle-aged subjects, implying that atherosclerotic examination in large arteries could reveal early-stage small artery retinopathy. changes that lead to primary organ damage 1-5). Hence, preventing the progressive processes of atherosclerosis is one of the most critical strategies in public health. Hypertension, dyslipidemia, diabetes mellitus, and smoking promoted atherosclerosis are established cardiovascular risk factors related to unhealthy Copyright©2020 Japan Atherosclerosis Society This article is distributed under the terms of the latest version of CC BY-NC-SA defined by the Creative Commons Attribution License.

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Carotid intima-media thickness is a novel predictor of new onset of hypertension in normotensive subjects

Cited by 17 publications

References 19 publications

Endothelial Function in Patients with Subclinical Hypothyroidism: A Meta-Analysis

Endothelial Function in Patients with Subclinical Hypothyroidism: A Meta-Analysis

Carotid intima-media thickness in patients with hyperuricemia: a systematic review and meta-analysis

Examination of Large Artery Atherosclerosis could Reveal Small Artery Retinopathy in Untreated Middle-Aged Individuals

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