CARP Is a Potential Tumor Suppressor in Gastric Carcinoma and a Single-Nucleotide Polymorphism in CARP Gene Might Increase the Risk of Gastric Carcinoma

Lü, Fang; Xue, Jianxin; Hu, Yongfeng; Gan, Lu; Shi, Yi; Yang, Huiling; Wei, Yuquan

doi:10.1371/journal.pone.0097743

Cited by 10 publications

(8 citation statements)

References 32 publications

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“…It was also demonstrated that CARP-1 and zyxin cooperate to promote apoptosis [26] . CARP-1 was found to be downregulated in 63% of gastric cancer tissues; of which, low-intensity staining was identified in 81% cases while no patients with gastric cancer had a high-intensity staining for CARP-1 [27] . Another study on zyxin found that it is downregulated in Ewing sarcoma where zyxin is more concentrated in the cytoplasm rather than cell adhesion junctions.…”

Section: Introductionmentioning

confidence: 95%

The role of zyxin in regulation of malignancies

Kotb¹,

Hyndman²,

Patel

2018

Heliyon

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Focal adhesions are highly dynamic multi-protein complexes found at the cell surface and effectively link the cell's internal cytoskeleton to a complex mixture of macromolecules known as the extracellular matrix and mediate transmission of signals from the extracellular matrix to the nucleus. Zyxin is one of the key focal adhesion proteins and is also found to shuttle in the nucleus. Although the mechanism of shuttling to the nucleus unclear, it moves out from the nucleus through a leucine-rich nuclear export signal sequence. It is known to contribute to fundamental cellular activities such as cell migration, adhesion and proliferation by interacting with a variety of cellular proteins. It is also linked with a number of cancers such as melanoma, hepatocellular carcinoma, oral squamous-cell carcinoma, Ewing sarcoma and prostate cancer. However, in many cases, the precise mechanisms by which the absence or presence of zyxin contributes to cancer progression or suppression is unknown. Thus, more work is required to gain insights into how zyxin modulates cellular functions in relationship to cancer. This review summarises the role of zyxin in cancer, with an emphasis on conflicting roles in prostate cancer.

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Section: Introductionmentioning

confidence: 95%

The role of zyxin in regulation of malignancies

Kotb¹,

Hyndman²,

Patel

2018

Heliyon

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“…Another example is MINDY3 in prostate cancer; MINDY3 codes for a protein that contains a caspase-associated recruitment domain and may be involved in apoptosis ( Safran et al 2010 ). Even though it has been identified as a tumor suppressor in lung and gastric cancers ( Lu et al 2014 ), our study is the first to link it with prostate cancer. For the same cancer type, prostate cancer, we find C9orf72, a gene that has been associated with several neurodegenerative disorders ( McCauley et al 2020 ).…”

Section: Resultsmentioning

confidence: 82%

A functional analysis of omic network embedding spaces reveals key altered functions in cancer

et al. 2023

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Motivation Advances in omics technologies have revolutionized cancer research by producing massive datasets. Common approaches to deciphering these complex data are by embedding algorithms of molecular interaction networks. These algorithms find a low-dimensional space in which similarities between the network nodes are best preserved. Currently available embedding approaches mine the gene embeddings directly to uncover new cancer-related knowledge. However, these gene-centric approaches produce incomplete knowledge, since they do not account for the functional implications of genomic alterations. We propose a new, function-centric perspective and approach, to complement the knowledge obtained from omic data. Results We introduce our Functional Mapping Matrix to explore the functional organization of different tissue-specific and species-specific embedding spaces generated by a Non-negative Matrix Tri-Factorization algorithm. Also, we use our FMM to define the optimal dimensionality of these molecular interaction network embedding spaces. For this optimal dimensionality, we compare the FMMs of the most prevalent cancers in human to FMMs of their corresponding control tissues. We find that cancer alters the positions in the embedding space of cancer-related functions, while it keeps the positions of the non-cancer-related ones. We exploit this spacial “movement” to predict novel cancer-related functions. Finally, we predict novel cancer-related genes that the currently available methods for gene-centric analyses cannot identify; we validate these predictions by literature curation and retrospective analyses of patient survival data. Availability Data and source code can be accessed at https://github.com/gaiac/FMM Supplementary information Supplementary data are available at Bioinformatics online.

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“…Overexpression of zinc finger, DHHC-type containing 14 (ZDHHC14) promotes the migration and invasion of scirrhous GC (4). Caspase-associated recruitment domain-containing protein (CARP) is a potential tumor suppressor in GC, and a single-nucleotide polymorphism in the CARP gene may increase the risk of GC (5). Ras association domain family member 10 (RASSF10) is an epigenetically silenced tumor suppressor in GC (6).…”

Section: Introductionmentioning

confidence: 99%

“…Ras association domain family member 10 (RASSF10) is an epigenetically silenced tumor suppressor in GC (6). It has previously been demonstrated that the inactivation of tumor suppressor genes and activation of oncogenes serve a significant role in carcinogenesis (3)(4)(5)(6). However, the etiology of GC remains poorly understood.…”

Section: Introductionmentioning

confidence: 99%

Lactotransferrin expression is downregulated and affects the mitogen-activated protein kinase pathway in gastric cancer

Luo

Zhou

et al. 2015

Oncology Letters

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Abstract. Gastric cancer (GC) is the second leading cause of cancer-associated mortality worldwide. In advanced and metastatic GC, conventional chemotherapy results in limited efficacy and the average survival rate is currently approximately 10 months. Dysregulated activation of numerous genes, including zinc finger, DHHC-type containing 14; caspase-associated recruitment domain-containing protein; and Ras association domain family member 10, have been implicated in GC. The tumor suppressor function of lactotransferrin (LTF) has been reported in a variety of tumors, including GC, nasopharyngeal carcinoma (NPC) and prostate cancer. However, the mechanism of the tumor suppressor function of LTF in GC remains unclear. In the present study, the expression levels of LTF in patient GC tissue samples were investigated using reverse transcription-quantitative polymerase chain reaction, and it was demonstrated that the LTF mRNA expression level in GC tissue samples was reduced by ~20-fold compared with the adjacent non-cancerous tissues (t=4.56, P<0.01). A similar trend in LTF protein expression was observed by western blot analysis. Furthermore, the present study demonstrated that the mitogen-activated protein kinase (MAPK) signaling pathway intermediates p38, c-Jun N-terminal kinase (JNK) and c-Jun were highly expressed in GC tissue samples, and indicated that LTF downregulation may be associated with the dysregulation of the MAPK signaling pathway in GC tissues. In addition, the present study indicated that LTF overexpression reduced the expression of p38, JNK2 and c-Jun in the GC cell line, SGC7901. The present study demonstrates that LTF expression is downregulated in GC tissues and that LTF may serve an important role in the dysregulation of the MAPK signaling pathway.

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CARP Is a Potential Tumor Suppressor in Gastric Carcinoma and a Single-Nucleotide Polymorphism in CARP Gene Might Increase the Risk of Gastric Carcinoma

Cited by 10 publications

References 32 publications

The role of zyxin in regulation of malignancies

The role of zyxin in regulation of malignancies

A functional analysis of omic network embedding spaces reveals key altered functions in cancer

Lactotransferrin expression is downregulated and affects the mitogen-activated protein kinase pathway in gastric cancer

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