Carrageenan Gels for Oral Sustained Delivery of Acetaminophen to Dysphagic Patients

Miyazaki, Shôzo; Ishitani, Mariko; Takahashi, Akie; Shimoyama, Tetsuya; Itoh, Ken; Attwood, David

doi:10.1248/bpb.34.164

Cited by 33 publications

(13 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The protocol for preparing the gelatin was based on the procedure described by Miyazaki et al (2011), while the used assay volume (125 mL) was based on the existing forms of commercial gelatin. The used extract amount (and corresponding microspheres) was defined considering the DPPH scavenging activity EC50 of the free extract (EC50 = 86.17 µg/mL).…”

Section: Incorporation Of Free and Microencapsulated F Vesca Extractmentioning

confidence: 99%

A bioactive formulation based on Fragaria vesca L. vegetative parts: Chemical characterisation and application in κ-carrageenan gelatin

Días

Barros

Fernandes

et al. 2015

Journal of Functional Foods

View full text Add to dashboard Cite

Available online A B S T R A C TA bioactive formulation based on the vegetative parts of the wild strawberry, Fragaria vesca L., was developed by using a microencapsulated extract (lyophilised infusion form). For that purpose, a process based on an atomisation/coagulation technique with alginate as the wall material was applied. Among the tested hydromethanolic and aqueous extracts, both obtained from wild and commercial samples, the infusion of a wild species emerged as the most antioxidative one. The higher amounts of flavonols and flavan-3-ols found in the aqueous extracts seem to be responsible for this greater antioxidant activity. Furthermore, the developed bioactive formulation was applied in k-carrageenan gelatin, which was observed to preserve the antioxidant properties of the extract as compared with the free form. Thus, the antioxidant activity of the F. vesca L. vegetative parts was demonstrated, as well as the advantages of using microencapsulation to produce effective bioactive formulations.

show abstract

Section: Incorporation Of Free and Microencapsulated F Vesca Extractmentioning

confidence: 99%

A bioactive formulation based on Fragaria vesca L. vegetative parts: Chemical characterisation and application in κ-carrageenan gelatin

Días

Barros

Fernandes

et al. 2015

Journal of Functional Foods

View full text Add to dashboard Cite

show abstract

“…Berdasarkan sifat fisikokimianya karagenan kappa dan iota dapat membentuk gel dengan mudah, terutama bila terdapat monovalen dan ion divalen. Gel yang dibentuk oleh iota karagenan memiliki reologi dan karakteristik pelepasan berkelanjutan, dengan potensi penggunaan sebagai kendaraan untuk pengiriman obat secara oral kepada pasien disfagik (Miyazaki et al, 2011).…”

Section: Karagenan Sebagai Agen Pembentuk Gel Atau Peningkat Viskositasunclassified

Karagenan dan Aplikasinya di Bidang Farmasetika

Prihastuti

Abdassah²

2019

Maj. Farmasetika

View full text Add to dashboard Cite

Karagenan merupakan polisakarida linier tersulfasi dari D-galaktosa dan 3, 6-anhidro-D-galaktosa yang diekstraksi secara komersial dari rumput laut merah kelas Rhodophyceae. Nama karagenan sendiri berasal dari spesies rumput laut yaitu Chondrus crispus yang dikenal sebagai Carrageen Moss atau Irish Moss di Inggris, dan Carraigin di Irlandia. Tiga tipe utama karagenan yang dibedakan berdasakan struktur diantaranya, kappa (κ), iota (ι), dan lambda (λ). Secara komersial karagenan digunakan sebagai agen pengental dan penstabil terutama pada produk makanan dan saus. Selain itu karagenan digunakan pada formulasi farmasetik dan kosmetik sebagai penstabil dalam sistem dispersi, pengatur viskositas dan sebagai pembentuk gel. Dalam bidang farmasetik karagenan banyak digunakan dalam sistem penghantaran obat untuk memperoleh kerja obat yang lebih panjang. Karagenan digunakan sebagai matriks tablet, ektruksi dalam pembuatan pelet, agen pembentuk gel, peningkat viskositas, peningkat permiabilitas dan digunakan pula dalam pembuatan mikrokapsul, beads serta nanopartikel. Selain itu karagenan juga digunakan dalam produksi antibiotik semi sintetik, tetrasiklin, klorotetrasiklin dan asam D-aspartat.Kata kunci: karagenan, aplikasi dalam bidang farmasetik, sistem penghantaran obat

show abstract

“…Liquids or powders can be used for such patients; however, there may be compliance issues, because these formulations do not have portability and they are also not easy to administer. To improve administration, jelly preparations (1)(2)(3), orally disintegrating tablets (4-7), and oral film preparations (8)(9)(10) have been developed. Although, almost all films can dissolve in the mouth, the films can only contain a small amount of drug.…”

Section: Introductionmentioning

confidence: 99%

Preparation of an oral acetaminophen film that is expected to improve medication administration: Effect of polyvinylpyrrolidone on physical properties of the film

Ito

Unezaki

2016

DD&T

View full text Add to dashboard Cite

Carrageenan Gels for Oral Sustained Delivery of Acetaminophen to Dysphagic Patients

Cited by 33 publications

References 8 publications

A bioactive formulation based on Fragaria vesca L. vegetative parts: Chemical characterisation and application in κ-carrageenan gelatin

A bioactive formulation based on Fragaria vesca L. vegetative parts: Chemical characterisation and application in κ-carrageenan gelatin

Karagenan dan Aplikasinya di Bidang Farmasetika

Preparation of an oral acetaminophen film that is expected to improve medication administration: Effect of polyvinylpyrrolidone on physical properties of the film

Contact Info

Product

Resources

About