Carrageenans as a New Source of Drugs with Metal Binding Properties

Khotimchenko, Yuri; Khozhaenko, E. V.; Khotimchenko, Maksim; Коленченко, Е. А.; Kovalev, Vladimir A.

doi:10.3390/md8041106

Cited by 36 publications

(20 citation statements)

References 11 publications

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“…Oxidation states of ions, including aluminum (III) and iron (III) ions, have been found to affect viscosity (Zabik, & Aldrich, 1967), but with negligible binding activity from yttrium (III) ions (Khotimchenko, Khozhaenko, Khotimchenko, Kolenchenko, & Kovalev, 2010), and observation of turbid solutions upon FeCl 3 addition (Jones, Cölfen, & Antoneitti, 2000). However, viscoelastic behaviors have not been reported previously, and to the best of our knowledge this communication is the first to describe gelation of lambda-carrageenan.…”

Section: Resultsmentioning

confidence: 99%

Trivalent iron induced gelation in lambda-carrageenan

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Falshaw

Janaswamy

2012

Carbohydrate Polymers

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This communication reports gelation of lambda-carrageenan, for the first time, in the presence of trivalent iron ions. Kappa-, iota- and lambda-carrageenans are sulfated polysaccharides used extensively in food, pharmaceutical and medical applications. Kappa- and iota-carrageenans show gelation in the presence of mono- and di-valent ions, but lambda-carrageenan yields only viscous solutions. Our results show that gelation in lambda-carrageenan indeed is possible, but with trivalent ions. X-ray fiber diffraction patterns of iron (III)-lambda-carrageenan are characteristic of highly oriented and polycrystalline fibers containing well resolved Bragg reflections. The elastic modulus (G') of the product is far greater than the loss modulus (G") indicating the thermal stability of lambda-carrageenan in the presence of iron (III) ions. This novel finding has potential to expand lambda-carrageenan’s current utility beyond a viscosifying agent.

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Section: Resultsmentioning

confidence: 99%

Trivalent iron induced gelation in lambda-carrageenan

Running

Falshaw

Janaswamy

2012

Carbohydrate Polymers

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“…Release of Pb(II) to the environment has caused widespread public concern due to its high toxicity and un-biodegradability [ 1 ]. A variety of removal technologies such as precipitation, membrane separation, solvent extraction have been widely investigated, but these methods are plagued since they are either economically impractical or producing huge amounts of secondary waste [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Algal Foams Applied in Fixed-Bed Process for Lead(II) Removal Using Recirculation or One-Pass Modes

Vincent¹,

Faur

Guibal³

2017

Marine Drugs

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The incorporation of brown algae into biopolymer beads or foams for metal sorption has been previously reported. However, the direct use of these biomasses for preparing foams is a new approach. In this study, two kinds of porous foams were prepared by ionotropic gelation using algal biomass (AB, Laminaria digitata) or alginate (as the reference) and applied for Pb(II) sorption. These foams (manufactured as macroporous discs) were packed in filtration holders (simulating fixed-bed column) and the system was operated in either a recirculation or a one-pass mode. Sorption isotherms, uptake kinetics and sorbent reuse were studied in the recirculation mode (analogous to batch system). In the one-pass mode (continuous fixed-bed system), the influence of parameters such as flow rate, feed metal concentration and bed height were investigated on both sorption and desorption. In addition, the effect of Cu(II) on Pb(II) recovery from binary solutions was also studied in terms of both sorption and desorption. Sorption isotherms are well fitted by the Langmuir equation while the pseudo-second order rate equation described well both sorption and desorption kinetic profiles. The study of material regeneration confirms that the reuse of the foams was feasible with a small mass loss, even after 9 cycles. In the one-pass mode, for alginate foams, a slower flow rate led to a smaller saturation volume, while the effect of flow rate was less marked for AB foams. Competitive study suggests that the foams have a preference for Pb(II) over Cu(II) but cannot selectively remove Pb(II) from the binary solution.

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“…Within the cell wall matrix of brown and red algae, ionic polysaccharides such as alginates, fucoidans and galactans are embedded. These polysaccharides contain a variety of functional sites, such as carboxylic and/or sulfonic acid, which are largely responsible for metal binding affinities of these polymers [35,36]. In the case of alginate, in particular its guluronic acid content, a strong affinity towards divalent cations such as Pb, Cu, Cd, Zn and Ca has been demonstrated [36].…”

Section: Ash and Metal Contentmentioning

confidence: 99%

The nutritional aspects of biorefined Saccharina latissima, Ascophyllum nodosum and Palmaria palmata

Schiener

SuFen

Theodoridou

et al. 2016

Biomass Conv. Bioref.

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The full-text may be used and/or reproduced, and given to third parties in any format or medium, without prior permission or charge, for personal research or study, educational, or not-for-prot purposes provided that: • a full bibliographic reference is made to the original source • a link is made to the metadata record in DRO • the full-text is not changed in any way The full-text must not be sold in any format or medium without the formal permission of the copyright holders. Please consult the full DRO policy for further details. Abstract The chemical profile of biorefined Saccharina latissima, Ascophylum nodosum and Palmaria palmata after carbohydrate and polyphenol extraction was analysed with the aim to evaluate the nutritional aspects of biorefined seaweeds as a novel animal feed supplement. Optimised enzymatic saccharification has been used to show that the protein concentration in the residue of Palmaria palmata and Ascophylum nodosum can be increased by more than two fold. Nutritional value of the residue was further enhanced through an increase in total amino acids and fatty acids. As a consequence of removal of inorganic elements such as sodium, potassium and chloride, the total solid and ash content of all three seaweeds was reduced by around 40%. In contrast, divalent metals such as iron and zinc, as well as silicon accumulated in all three residues. Potentially harmful components such as arsenic and iodine were reduced only in brown biorefined seaweeds, whilst in biorefined P. palmata iodine increased by 39% compared to a 24% decline of arsenic. Polyphenol removal in all three seaweeds was >80% and, in combination with enzymatic saccharification, enhanced protein recovery in A. nodosum. This highlights the potential of biorefinery concepts to generate multiple products from seaweed such as extracts enriched in polyphenols and carbohydrates and residue with higher protein and lipid content.

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Carrageenans as a New Source of Drugs with Metal Binding Properties

Cited by 36 publications

References 11 publications

Trivalent iron induced gelation in lambda-carrageenan

Trivalent iron induced gelation in lambda-carrageenan

Algal Foams Applied in Fixed-Bed Process for Lead(II) Removal Using Recirculation or One-Pass Modes

The nutritional aspects of biorefined Saccharina latissima, Ascophyllum nodosum and Palmaria palmata

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