Cartilage and Soft Tissue Imaging Using X-rays

Horng, Annie; Brun, Emmanuel; Mittone, Alberto; Gasilov, S. V.; Weber, Loriane; Geith, Tobias; Adam-Neumair, Silvia; Auweter, Sigrid; Bravin, A.; Reiser, Maximilian; Coan, Paola

doi:10.1097/rli.0000000000000063

Cited by 74 publications

(39 citation statements)

References 30 publications

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“…technique of interest to biomedical research for its ability to visualize soft-matter biological tissues [33][34][35][36] , providing a sensitivity 2 to 3 order of magnitudes higher than that of absorption CT 37,38 in the hard X-ray regime. We presume that PCI-CT might be able to contribute to the study of X-ray irradiation effects on brain tissue, since the technique was reported to provide high nervous-tissue contrast complementary to MRI 39…”

Section: X-ray Phase Contrast Ct (Pci-ct) Is An Experimental High-resmentioning

confidence: 99%

Micro-imaging of Brain Cancer Radiation Therapy Using Phase-contrast Computed Tomography

Barbone

Bravin

Romanelli³

et al. 2018

International Journal of Radiation Oncology*Biology*Physics

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Section: X-ray Phase Contrast Ct (Pci-ct) Is An Experimental High-resmentioning

confidence: 99%

Micro-imaging of Brain Cancer Radiation Therapy Using Phase-contrast Computed Tomography

Barbone

Bravin

Romanelli³

et al. 2018

International Journal of Radiation Oncology*Biology*Physics

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“…Several applications have confirmed the higher sensitivity of XPC compared with conventional radiology, sometimes opening new applications that were previously impossible using conventional X-ray imaging. To mention some: mammography (Castelli et al, 2011;Wang et al, 2014), lung research (Lewis et al, 2005) and cartilage imaging (Muehleman et al, 2004;Tanaka et al, 2013;Horng et al, 2014). Thanks to XPC, Ap are visible without the need for contrast agents such as tracers or dyes.…”

Section: Introductionmentioning

confidence: 99%

Amyloid-β plaque deposition measured using propagation-based X-ray phase contrast CT imaging

et al. 2016

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“…Additionally, although PCI and ACI have different imaging abilities for vessel detection, both exhibit significant correlations with the histological method, as determined in our study. These methods have been used in combination with histology for cerebellum visualization, the early diagnosis of breast cancer and hyaline cartilage imaging (Zhao et al, 2012;Schulz et al, 2010;Horng et al, 2014). Although previous research studies have been conducted in this area, the 3D visualization of the intramedullary artery structure in the spinal cord by PCI and ACI combined with histological methods remains a challenge.…”

Section: Discussionmentioning

confidence: 99%

Visualization of mouse spinal cord intramedullary arteries using phase- and attenuation-contrast tomographic imaging

Cao

Zhang

et al. 2016

J Synchrotron Radiat

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Many spinal cord circulatory disorders present the substantial involvement of small vessel lesions. The central sulcus arteries supply nutrition to a large part of the spinal cord, and, if not detected early, lesions in the spinal cord will cause irreversible damage to the function of this organ. Thus, early detection of these small vessel lesions could potentially facilitate the effective diagnosis and treatment of these diseases. However, the detection of such small vessels is beyond the capability of current imaging techniques. In this study, an imaging method is proposed and the potential of phase-contrast imaging (PCI)- and attenuation-contrast imaging (ACI)-based synchrotron radiation for high-resolution tomography of intramedullary arteries in mouse spinal cord is validated. The three-dimensional vessel morphology, particularly that of the central sulcus arteries (CSA), detected with these two imaging models was quantitatively analyzed and compared. It was determined that both PCI- and ACI-based synchrotron radiation can be used to visualize the physiological arrangement of the entire intramedullary artery network in the mouse spinal cord in both two dimensions and three dimensions at a high-resolution scale. Additionally, the two-dimensional and three-dimensional vessel morphometric parameter measurements obtained with PCI are similar to the ACI data. Furthermore, PCI allows efficient and direct discrimination of the same branch level of the CSA without contrast agent injection and is expected to provide reliable biological information regarding the intramedullary artery. Compared with ACI, PCI might be a novel imaging method that offers a powerful imaging platform for evaluating pathological changes in small vessels and may also allow better clarification of their role in neurovascular disorders.

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Cartilage and Soft Tissue Imaging Using X-rays

Abstract: Phase-contrast imaging CT may facilitate a more complete evaluation of the human knee joint by providing concurrent comprehensive information about cartilage, the underlying subchondral bone, and their changes in osteoarthritic conditions.

Cited by 74 publications

References 30 publications

Micro-imaging of Brain Cancer Radiation Therapy Using Phase-contrast Computed Tomography

Micro-imaging of Brain Cancer Radiation Therapy Using Phase-contrast Computed Tomography

Amyloid-β plaque deposition measured using propagation-based X-ray phase contrast CT imaging

Visualization of mouse spinal cord intramedullary arteries using phase- and attenuation-contrast tomographic imaging

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