Cartilage Oligomeric Matrix Protein (COMP): A Biomarker of Arthritis

Abstract

Arthritis is a chronic disease with a signifi cant impact on the population. It damages the cartilage, synovium, and bone of the joints causing pain, impairment, and disability in patients. Current methods for diagnosis of and monitoring the disease are only able to detect clinical manifestations of arthritis late in the process. However, with the recent onset of successful treatments for rheumatoid arthritis and osteoarthritis, it becomes important to identify prognostic factors that can predict the evolution of arthritis. This is especially critical in the early phases of disease so that these treatments can be started as soon as possible to slow down progression of the disease. A valuable approach to monitor arthritis would be by measuring biological markers of cartilage degradation and repair to refl ect variations in joint remodeling. One such potential biological marker of arthritis is cartilage oligomeric matrix protein (COMP). In various studies, COMP has shown promise as a diagnostic and prognostic indicator and as a marker of the disease severity and the effect of treatment. This review highlights the progress in the utilization of COMP as a biomarker of arthritis.

Efficacy of Chondroitin Sulfate for Painful Knee Osteoarthritis: A One-Year, Randomized, Double-Blind, Multicenter Clinical Study in Japan

“…Cartilage oligomeric matrix protein (COMP) is a well-established biomarker for OA, with its serum level reportedly increasing as the disease progresses, 39) whereas HA synthesis has been shown to be greater in inflamed synovium, resulting in an increase in the serum level of HA. 40,41) Therefore, we evaluated serum levels of COMP and HA before and after CS therapy.…”

Immunosuppressive Effects of Mesenchymal Stem Cells versus Corticosteroid in Experimental Model of Arthritis

“…COMP is associated with cartilage breakdown and has been studied as a potential diagnostic and prognostic indicator as well as a marker of disease severity or the efficacy of treatment Tseng et al [33].…”

Correlation Study of Disease Activity Score and Serum Cartilage Oligomeric Matrix Proteinlevels of Rheumatoid Arthritis Patients in Bandung, Indonesia

“…Cartilage oligomeric matrix protein (COMP) is a potential biomarker to support the RA diagnosis [5]. COMP was contributed in assembly the collagen fiber type II in cartilage and in cooperation with other matrix proteins which stabilize the collagen network [6].…”