2014
DOI: 10.1002/jbm.a.35126
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Cartilage regeneration using biodegradable oxidized alginate/hyaluronate hydrogels

Abstract: Despite the widespread use of alginate (AL) hydrogels in many biomedical applications, including tissue engineering, AL is inherently non-degradable under physiological conditions. We hypothesized that degradable alginate (dAL) would be useful for cartilage regeneration when combined with hyaluronate (HA). We prepared dAL by partial oxidation of AL using sodium periodate, and the degradation rate of AL hydrogel was able to be regulated by control of sodium periodate concentration. The degradable oxidized AL/HA… Show more

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Cited by 38 publications
(37 citation statements)
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“…Furthermore, owing to its lack of cell adhesion ability, alginate is usually blended with other polymers. 143,144 An injectable, biodegradable, oxidized alginate/hyaluronic acid hydrogel has been prepared by Park and Lee. 143 At 6 weeks after injection of the hydrogel with primary chondrocytes into mice, effective cartilage regeneration has been observed.…”
Section: Injectable Hydrogels Prepared With Different Biomaterialsmentioning
confidence: 99%
See 1 more Smart Citation
“…Furthermore, owing to its lack of cell adhesion ability, alginate is usually blended with other polymers. 143,144 An injectable, biodegradable, oxidized alginate/hyaluronic acid hydrogel has been prepared by Park and Lee. 143 At 6 weeks after injection of the hydrogel with primary chondrocytes into mice, effective cartilage regeneration has been observed.…”
Section: Injectable Hydrogels Prepared With Different Biomaterialsmentioning
confidence: 99%
“…143,144 An injectable, biodegradable, oxidized alginate/hyaluronic acid hydrogel has been prepared by Park and Lee. 143 At 6 weeks after injection of the hydrogel with primary chondrocytes into mice, effective cartilage regeneration has been observed. In another study, a class of biocompatible and biodegradable alginate-based hydrogel blend has been synthesized by using alginate and O -carboxymethyl chitosan with the addition of fibrin nanoparticles.…”
Section: Injectable Hydrogels Prepared With Different Biomaterialsmentioning
confidence: 99%
“…The physiological environment of articular cartilage is typically avascular and aneural . Moreover, it is well established that the microenvironment of cartilage is hypoxic, with oxygen (O 2 ) tension ranging from <10% at the surface to <1% in the deepest layer …”
Section: Introductionmentioning
confidence: 99%
“…The physiological environment of articular cartilage is typically avascular and aneural. 1 Moreover, it is well established that the microenvironment of cartilage is hypoxic, with oxygen (O 2 ) tension ranging from <10% at the surface to <1% in the deepest layer. 2 However, although cartilage naturally resides in this specific low oxygen tension microenvironment, articular chondrocytes are customarily cultured at normal atmospheric oxygen tension (19-21%).…”
Section: Introductionmentioning
confidence: 99%
“…A limitation of alginate is that it frequently does not interact with cells and proteins. As stated above, it is necessary for alginate to be combined in a scaffold with another compound that increases its cell attachment capabilities to optimize regeneration of the tissue . Although hydrogels, like alginate, generally promote regeneration, they are not suitable for load‐bearing applications .…”
Section: Materials Used For 3d Bioprintingmentioning
confidence: 99%