Carvedilol improves glucose tolerance and insulin sensitivity in treatment of adrenergic overdrive in high fat diet-induced obesity in mice

Nguyen, Linh V.; Ta, Quang Van; Dang, Thao; Nguyen, Phu Hung; Nguyen, Thach; Pham, Thi Van Huyen; Nguyen, Trang; Baker, Stephen; Tran, Le Trung; Yang, Dong; Kim, Ki Woo; Doan, Khanh V.

doi:10.1371/journal.pone.0224674

Cited by 17 publications

(11 citation statements)

References 47 publications

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“…Leptin, an adipose tissue-derived cytokine, acts as a regulator of appetite and energy homeostasis. The association between leptin dysfunction and progression of insulin resistance has previously documented ( van der Wijden et al, 2015 ), and hyperleptinemia has been associated with insulin resistance in HFD-induced obese mice ( Nguyen et al, 2019 ). After 6 weeks of treatment with MC, obese mice had decreased hyperleptinemia and significantly elevated levels of serum adiponectin.…”

Section: Discussionmentioning

confidence: 97%

Mentha cordifolia Leaf Extract Improves Hepatic Glucose and Lipid Metabolism in Obese Mice Fed with High-Fat Diet

Naowaboot

Nanna

Chularojmontri

et al. 2021

Prev. Nutr. Food Sci.

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Mentha cordifolia (MC) is a popular herb used to flavor food in Thailand that exhibits several biological effects. The present study aimed to determine the role of MC in regulating glucose and lipid metabolism in mice fed a high-fat diet (HFD). ICR obese mice were fed an HFD (45 kcal% lard fat) for 12 weeks, with MC (100 and 200 mg/kg/d) treatment from Week 7. After treatment with MC for 6 weeks, mice showed significantly lower rates of hyperglycemia, hyperinsulinemia, hyperleptinemia, and hyperlipidemia, and increased amounts of serum adiponectin. Furthermore, in mice treated with MC, serum interleukin-6 and tumor necrosis factor alpha were significantly inhibited and liver histology results showed decreased lipid accumulation and liver triglyceride content vs. untreated mice. In addition, MC treatment was associated with smaller fat cells and lower gene expression of liver sterol regulatory element binding protein 1c, acetyl-CoA carboxylase, and fatty acid synthase. However, MC treatment was associated with higher carnitine palmitoyltransferase 1a gene expression and significantly higher rates of adenosine monophosphate-activated protein kinase (AMPK) phosphorylation in liver, but lower levels of phosphoenolpyruvate carboxykinase and glucose-6-phosphatase. These results indicate MC regulates glucose and lipid metabolism in a HFD-induced obese mouse model, possibly via activation of AMPK signaling pathway.

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Section: Discussionmentioning

confidence: 97%

Mentha cordifolia Leaf Extract Improves Hepatic Glucose and Lipid Metabolism in Obese Mice Fed with High-Fat Diet

Naowaboot

Nanna

Chularojmontri

et al. 2021

Prev. Nutr. Food Sci.

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“…3AR-specific agonists rescue metabolic dysfunction in mice [32][33][34] , cause beigeing of iWAT more than eWAT 35 , and enhances lipolysis and insulin secretion 36 , but 2AR-specific antagonists improve glucose and insulin tolerance without affecting body weight 37 . The three ARs have been genetically deleted.…”

Section: Discussionmentioning

confidence: 99%

Gnas ablation in CD11c+ cells prevents high-fat diet-induced obesity by elevating adipose tissue catecholamine levels and thermogenesis

Zeng

Herdman

Lee

et al. 2022

Preprint

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CD11c+ immune cells are a potential therapeutic target for treatment of obesity-related insulin resistance and type 2 diabetes (T2D). In obesity, CD11c+ immune cells are recruited to white adipose tissue and create an inflammatory state that causes both insulin and catecholamine resistance. In this study, we found that ablation of Gnas, the gene that encodes Gαs, in CD11c expressing cells protects mice from high-fat diet-induced obesity, glucose intolerance and insulin resistance. GnasΔCD11c mice (KO) had increased oxygen consumption, energy expenditure, and beigeing of white adipose tissue (WAT). Transplantation studies showed that the lean phenotype was conferred by bone marrow-derived cells and the absence of T and B cells by crossing the KO to a Rag1-/- background did not alter the phenotype. Notably, we observed elevated norepinephrine and elevated cAMP signaling in the WAT of KO mice. The KO adipose tissue also had reduced expression of catecholamine transport and degradation enzymes. Collectively, our results identified an important role of Gαs in CD11c+ cells in whole body metabolism regulation by controlling norepinephrine levels in WAT, modulating catecholamine-induced lipolysis and increasing thermogenesis that together created a lean phenotype.

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“…A previous study reported that dyslipidemia model mice had a narrowed incisor dental pulp cavity 41 . Others that investigated the relationship between leptin and the LDL receptor also showed that HFD consumption induced increased plasma leptin levels in both WT and Ldlr −/− mice 42,43 , while it is known that leptin promotes odontoblastic differentiation 44,45 . Together, these findings indicate that an increased plasma leptin level induces narrowed pulp with thickened dentin in WT mice.…”

Section: Discussionmentioning

confidence: 99%

Effects of lipid metabolism on mouse incisor dentinogenesis

Kurotaki

Sakai

Miyazaki

et al. 2020

Sci Rep

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Tooth formation can be affected by various factors, such as oral disease, drug administration, and systemic illness, as well as internal conditions including dentin formation. Dyslipidemia is an important lifestyle disease, though the relationship of aberrant lipid metabolism with tooth formation has not been clarified. This study was performed to examine the effects of dyslipidemia on tooth formation and tooth development. Dyslipidemia was induced in mice by giving a high-fat diet (HFD) for 12 weeks. Additionally, LDL receptor-deficient (Ldlr −/− ) strain mice were used to analyze the effects of dyslipidemia and lipid metabolism in greater detail. In the HFD-fed mice, incisor elongation was decreased and pulp was significantly narrowed, while histological findings revealed disappearance of predentin. In Ldlr −/− mice fed regular chow, incisor elongation showed a decreasing trend and pulp a narrowing trend, while predentin changes were unclear. Serum lipid levels were increased in the HFDfed wild-type (WT) mice, while Ldlr −/− mice given the HFD showed the greatest increase. These results show important effects of lipid metabolism, especially via the LDL receptor, on tooth homeostasis maintenance. In addition, they suggest a different mechanism for WT and Ldlr −/− mice, though the LDL receptor pathway may not be the only factor involved.A regular high-fat diet (HFD) has been shown to result in such lifestyle diseases as dyslipidemia, obesity, and diabetes 1,2 . Notably, dyslipidemia causes serious alterations of systemic tissue, including accumulation of lipids in blood vessel walls and the liver 3,4 . It has also been reported that lipid metabolism alteration produces changes in calcified tissue phenotypes 5 . Low-density lipoprotein (LDL) is known to transport cholesterol produced in the liver to peripheral cells 6 . However, as noted above, an increase in native LDL in blood induces dyslipidemia and atherosclerosis, which then induces typical cardiovascular events such as cardiac and cerebral infarction 7 . Increasing evidence shows that lifestyle, especially diet, can induce chronic disease. Furthermore, a previous study showed that patients with dyslipidemia can develop osteoporosis [8][9][10] . The gene disorder related to lipid metabolism known as familial hypercholesterolemia (FH) has been shown to be related to development of coronary heart disease as well as the LDL receptor, which is essential for lipid uptake 11,12 . Also, patients with FH have been reported to develop Achilles tendon (AT) xanthomas, resulting in an incrassate AT condition 13,14 , suggesting increased collagen in the tendon. However, detailed analysis findings regarding bone or teeth in FH patients are scarce. There are some reports of the relationship of lipids and teeth based on analyses of the components of enamel [15][16][17] and dentin 17-20 , though details regarding the effects of lipid metabolism aberration on tooth

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Carvedilol improves glucose tolerance and insulin sensitivity in treatment of adrenergic overdrive in high fat diet-induced obesity in mice

Cited by 17 publications

References 47 publications

Mentha cordifolia Leaf Extract Improves Hepatic Glucose and Lipid Metabolism in Obese Mice Fed with High-Fat Diet

Mentha cordifolia Leaf Extract Improves Hepatic Glucose and Lipid Metabolism in Obese Mice Fed with High-Fat Diet

Gnas ablation in CD11c+ cells prevents high-fat diet-induced obesity by elevating adipose tissue catecholamine levels and thermogenesis

Effects of lipid metabolism on mouse incisor dentinogenesis

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