Cascade catalytic nanoplatform for enhanced starvation and sonodynamic therapy

Zhang, Yingjie; Wang, Huiling; Jia, Xuedong; Du, Shouying; Yin, Yong; Zhang, Xiaojian

doi:10.1080/1061186x.2019.1641507

Cited by 46 publications

(27 citation statements)

References 41 publications

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“…[133] MnO 2 nanomaterials together with GOx are widely applied to starvation therapy by a cascade reaction to disrupt the glucose metabolism, thereby suppressing adenosine triphosphate (ATP) production. [29,134] As shown in Figure 18, MnO 2 -GOx-hyaluronic acid (MG/HA) nanoplatforms were built to achieve O 2 -promoted starvation therapy. [135] Here, GOx can catalyze the oxidation of glucose into gluconic acid and H 2 O 2 accompanying the consumption of O 2 .…”

Section: Starvation Therapymentioning

confidence: 99%

Manganese Oxide Nanomaterials: Synthesis, Properties, and Theranostic Applications

et al. 2020

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Despite the comprehensive applications in bioimaging, biosensing, drug/gene delivery, and tumor therapy of manganese oxide nanomaterials (MONs including MnO2, MnO, Mn2O3, Mn3O4, and MnOx) and their derivatives, a review article focusing on MON‐based nanoplatforms has not been reported yet. Herein, the representative progresses of MONs on synthesis, heterogene, properties, surface modification, toxicity, imaging, biodetection, and therapy are mainly introduced. First, five kinds of primary synthetic methods of MONs are presented, including thermal decomposition method, exfoliation strategy, permanganates reduction method, adsorption–oxidation method, and hydro/solvothermal. Second, the preparations of hollow MONs and MON‐based composite materials are summarized specially. Then, the chemical properties, surface modification, and toxicity of MONs are discussed. Next, the diagnostic applications including imaging and sensing are outlined. Finally, some representative rational designs of MONs in photodynamic therapy, photothermal therapy, chemodynamic therapy, sonodynamic therapy, radiotherapy, magnetic hyperthermia, chemotherapy, gene therapy, starvation therapy, ferroptosis, immunotherapy, and various combination therapy are highlighted.

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Section: Starvation Therapymentioning

confidence: 99%

Manganese Oxide Nanomaterials: Synthesis, Properties, and Theranostic Applications

et al. 2020

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“…The GOx was shown to first catalyze the oxidization of glucose into H 2 O 2 and gluconic acid for starvation therapy. [125] The generated H 2 O 2 was further catalyzed by MnO 2 to generate O 2 , which in turn supplied the glucose-depletion reaction in starvation therapy and enhanced the generation of ROS in the HMME-mediated SDT process. Both in vitro and in vivo experiments have confirmed advantages of such the synergistic effect.…”

Section: Sonodynamic Therapy Combined With Starvation Therapymentioning

confidence: 99%

Recent Advances in Nanomaterial‐Assisted Combinational Sonodynamic Cancer Therapy

et al. 2020

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Ultrasound (US)-triggered sonodynamic therapy (SDT), as a promising noninvasive therapeutic modality, has received ever-increasing attention in recent years. Its specialized chemical agents, named sonosensitizers, are activated by low-intensity US to produce lethal reactive oxygen species (ROS) for oncotherapy. Compared with phototherapeutic strategies, SDT provides many noteworthy opportunities and benefits, such as deeper penetration depth, absence of phototoxicity, and fewer side effects. Nevertheless, previous studies have also demonstrated its intrinsic limitations. Thanks to the facile engineering nature of nanotechnology, numerous novel nanoplatforms are being applied in this emerging field to tackle these intrinsic barriers and achieve continuous innovations. In particular, the combination of SDT with other treatment strategies has demonstrated a superior efficacy in improving anticancer activity relative to that of monotherapies alone. Therefore, it is necessary to summarize the nanomaterial-assisted combinational sonodynamic cancer therapy applications. Herein, the design principles in achieving synergistic therapeutic effects based on nanomaterial engineering methods are highlighted. The ultimate goals are to stimulate the design of better-quality combined sonodynamic treatment schemes and provide innovative ideas for the perspectives of SDT in promoting its future transformation to clinical application.

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“…As shown in Fig. 4, Zhang et al used the mesoporous MnO2 NPs as a loading platform [82]. The surface of MnO2 NPs was modified with glucose oxidase (GOx), and the inner pores were loaded with molecular sonosensitizers (hematoporphyrin monomethyl ether, HMME).…”

Section: Inorganic Nanomaterials As the Nano Carriers Of Molecular Somentioning

confidence: 99%

“…Schematic illustration of the cascade catalytic nanoplatform (GOx-MnO2/HMME) for enhanced starvation and sonodynamic therapy (reproduced with permission from Ref [82],. © Taylor & Francis 2020).…”

mentioning

confidence: 99%

Recent advances in nanomaterials for sonodynamic therapy

et al. 2020

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Sonodynamic therapy (SDT), as a novel non-invasive strategy for eliminating tumor, has the advantages of deeper tissue penetration, fewer side effects, and better patient compliance, compared with photodynamic therapy (PDT). In SDT, ultrasound was used to activate sonosensitizer to produce cytotoxic reactive oxygen species (ROS), induce the collapse of vacuoles in solution, and bring about irreversible damage to cancer cells. In recent years, much effort has been devoted to developing highly efficient sonosensitizers which can efficiently generate ROS. However, the traditional organic sonosensitizers, such as porphyrins, hypericin, and curcumins, suffer from complex synthesis, poor water solubility, and low tumor targeting efficacy which limit the benefits of SDT. In contrast, inorganic sonosensitizers show good in vivo stability, controllable physicochemical properties, ease of achieving multifunctionality, and high tumor targeting, which greatly expanded their application in SDT. In this review, we systematically summarize the nanomaterials which act as the carrier of molecular sonosensitizers, and directly produce ROS under ultrasound. Moreover, the prospects of inorganic nanomaterials for SDT application are also discussed.

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Cascade catalytic nanoplatform for enhanced starvation and sonodynamic therapy

Cited by 46 publications

References 41 publications

Manganese Oxide Nanomaterials: Synthesis, Properties, and Theranostic Applications

Manganese Oxide Nanomaterials: Synthesis, Properties, and Theranostic Applications

Recent Advances in Nanomaterial‐Assisted Combinational Sonodynamic Cancer Therapy

Recent advances in nanomaterials for sonodynamic therapy

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