Case-control cytogenetic study in offspring of mothers treated with bromocriptine during early pregnancy

Hyperprolactinemia and Woman’s Health

“…Studies have shown successful ovulation induction and pregnancy with BC in the absence of galactorrhea or HP in previous nonresponders to clomiphin (Porcile, et al;. Pregnancies that result from BC therapy do not appear to be at increased teratogenic risk (Czeizel, et al;, even though BC crosses the placenta and lowers fetal PRL concentrations (Bigazzi, et al;. Nevertheless, it is recommended that BC treatment be stopped when pregnancy is diagnosed to avoid potential risks to fetal neural development.…”

“…Binding of DAs to dopamine D2 receptors on the surface of lactotroph cells reduces AC activity and inhibits PRL secretion (Melmed, 1997). Several DA therapies are available for the treatment of HP and are outlined in the following table (Hutchinson and Zacur, 1997): Long history of use; does not appear to be teratogenic (Czeizel, et al;; inexpensive Good efficacy; low frequency of adverse events; may be useful in BC-resistant patients 1997); weekly or twice-weekly dose Good efficacy and tolerability (Webster, 1996) DAs play a major role in the management of both idiopathic/non-tumoral and prolactinoma-related PRL excess. These agents act on dopamine D2-type receptors on pituitary lactotroph cells, resulting in a decrease in synthesis and release of PRL (Vallar, et al;.…”

Genética‌‌ de‌‌ las‌‌ fisuras‌‌ labiopalatinas‌‌:‌ una‌‌ visión‌ general‌‌ de‌‌ los‌‌ factores‌‌ de‌‌ riesgo‌‌ genéticos‌‌ y‌‌ ambientales

“…Los estudios realizados por Safra y Oakley dieron cuenta de la asociación de CLP con la exposición al diazepam durante el primer trimestre del embarazo (30). Así mismo, los trabajos presentados por Czeizel et al, abordaron la cuestión de la teratogenicidad de las benzodiazepinas en su conjunto (31). Aunque el diazepam en dosis altas es un teratógeno débil en ratones susceptibles, su interferencia con el desarrollo de la cara fetal es probablemente modesta o inexistente.…”