Case–control risk factor study of methicillin-resistant Staphylococcus pseudintermedius (MRSP) infection in dogs and cats in Germany

Lehner, Georg; Линек, Моника; Bond, R.; Lloyd, D. H.; Prenger‐Berninghoff, Ellen; Thom, Nina; Straube, Iris; Verheyen, K. L. P.; Loeffler, Anette

doi:10.1016/j.vetmic.2013.10.023

Cited by 75 publications

(71 citation statements)

References 35 publications

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“…In agreement with the present study, other studies have also found that isolates from surgical site infections were at higher risk of being resistant to methicillin when compared to other sites [10, 40]. In parallel to the work here, animals that were hospitalised, visited veterinary clinics frequently or had previous antimicrobial treatment were at higher risk for MRSP infections [41]. Compared to studies from 2006, [20, 34] it appears that MRSP infections are becoming increasingly common in veterinary companion animal practice in Australia.…”

Section: Discussionsupporting

confidence: 92%

Antimicrobial resistance in coagulase-positive staphylococci isolated from companion animals in Australia: A one year study

et al. 2017

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Methicillin-resistant coagulase-positive staphylococci (CoPS) have become increasingly recognised as opportunistic pathogens that limit therapeutic options in companion animals. The frequency of methicillin resistance amongst clinical isolates on an Australia-wide level is unknown. This study determined antimicrobial susceptibility patterns for CoPS isolated from clinical infections in companion animals (dogs, cats and horses) as part of the first nation-wide survey on antimicrobial resistance in animal pathogens in Australia for a one-year period (January 2013 to January 2014). Clinical Staphylococcus spp. isolates (n = 888) obtained from 22 veterinary diagnostic laboratories were identified by MALDI-TOF mass spectrometry and subjected to antimicrobial susceptibility testing for 16 antimicrobials, representing 12 antimicrobial classes. Potential risk factors associated with methicillin resistance in Staphylococcus pseudintermedius isolates from dogs were analysed based on demographic factors and clinical history, including gender, age, previous antimicrobial treatment, chronic and/or recurrent diseases and site of infections. The most commonly identified CoPS were S. pseudintermedius (70.8%; dogs n = 616, cats n = 13) and S. aureus (13.2%, horses n = 53, dogs n = 47 and cats n = 17). Overall, the frequency of methicillin resistance among S. pseudintermedius (MRSP) and S. aureus (MRSA) was 11.8% and 12.8%, respectively. MRSP isolates were strongly associated with resistance to fluoroquinolones (OR 287; 95%CI 91.2–1144.8) and clindamycin (OR 105.2, 95%CI 48.5–231.9). MRSA isolates from dogs and cats were also more likely to be resistant to fluoroquinolones (OR 5.4, 95%CI 0.6–252.1), whereas MRSA from horses were more likely to be resistant to rifampicin. In multivariate analysis, MRSP-positive status was significantly associated with particular infection sites, including surgical (OR 8.8; 95%CI 3.74–20.7), and skin and soft tissue (OR 3.9; 95%CI 1.97–7.51). S. pseudintermedius isolated from dogs with surgical site infections were three times more likely to be methicillin-resistant if cases had received prior antimicrobial treatment. Whilst the survey results indicate the proportion of CoPS obtained from Australian companion animals that are methicillin-resistant is currently moderate, the identified risk factors suggest that it could rapidly increase without adequate biosecurity and infection control procedures in veterinary practice.

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Section: Discussionsupporting

confidence: 92%

Antimicrobial resistance in coagulase-positive staphylococci isolated from companion animals in Australia: A one year study

et al. 2017

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“…There are now innumerable examples of the remarkable clonal spread of resistant pathogens in companion animals, including CTX-M-15-D-ST648 Escherichia coli (Ewers and others 2014a), ST15-CTX-M-15 Klebsiella pneumoniae (Ewers and others 2014b) and other extended-spectrum beta-lactamase-producing Enterobacteriaceae (Wieler and others 2011) in Europe, and the emergence and clonal spread of MRSP throughout Europe and North America (Perreten and others 2010). The increasing resistance of canine MRSP in the UK (and elsewhere) is well documented (Beever and others 2015), as is the higher frequency of MRSP infections in cats and dogs that have been hospitalised or visited veterinary clinics (Lehner and others 2014). Companion animal practitioners are sources of MRSA or MRSP (Jordan and others 2011, Paul and others 2011) and hand hygiene practices in companion animal medicine often leave a lot to be desired (Nakamura and others 2012).…”

mentioning

confidence: 99%

Antimicrobial use in companion animals and Good Stewardship Practice

Prescott¹

2016

Veterinary Record

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“…MSSP isolates were selected throughout the study period using simple randomization on www.randomizer.org.19 Data and pedigree information were obtained from the Swedish Dairy Association (Stockholm, Sweden), and the Swedish organic certification organization (KRAV; Uppsala, Sweden) contributed information about dairy farms with organic plant production. … The initial data set contained records from 402 organic herds (all herds with available data) and 5,335 ….…”

Section: (B) Describe the Sources And Methods Of Selection For The Omentioning

confidence: 99%

“…These results indicate an association of MRSP infection with veterinary clinic/hospital settings and possibly with chronic skin disease. There was an unexpected lack of association between MRSP and antimicrobial therapy; this requires further investigation…19 …”

Section: (B) Indicate Why the Study Was Conducted The Approach Thementioning

confidence: 99%

Explanation and Elaboration Document for the STROBE‐Vet Statement: Strengthening the Reporting of Observational Studies in Epidemiology—Veterinary Extension

O’Connor

Sargeant

Dohoo

et al. 2016

Veterinary Internal Medicne

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The STROBE (Strengthening the Reporting of Observational Studies in Epidemiology) statement was first published in 2007 and again in 2014. The purpose of the original STROBE was to provide guidance for authors, reviewers, and editors to improve the comprehensiveness of reporting; however, STROBE has a unique focus on observational studies. Although much of the guidance provided by the original STROBE document is directly applicable, it was deemed useful to map those statements to veterinary concepts, provide veterinary examples, and highlight unique aspects of reporting in veterinary observational studies. Here, we present the examples and explanations for the checklist items included in the STROBE‐Vet statement. Thus, this is a companion document to the STROBE‐Vet statement methods and process document (JVIM_14575 “Methods and Processes of Developing the Strengthening the Reporting of Observational Studies in Epidemiology—Veterinary (STROBE‐Vet) Statement” undergoing proofing), which describes the checklist and how it was developed.

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Case–control risk factor study of methicillin-resistant Staphylococcus pseudintermedius (MRSP) infection in dogs and cats in Germany

Cited by 75 publications

References 35 publications

Antimicrobial resistance in coagulase-positive staphylococci isolated from companion animals in Australia: A one year study

Antimicrobial resistance in coagulase-positive staphylococci isolated from companion animals in Australia: A one year study

Antimicrobial use in companion animals and Good Stewardship Practice

Explanation and Elaboration Document for the STROBE‐Vet Statement: Strengthening the Reporting of Observational Studies in Epidemiology—Veterinary Extension

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