Case–Control Study to Find Association of Common RTIs with CIN and Cervical Cancer

Gupta, Radha; Singh, Nisha; Kalyan, Raj Kumar; Agrawal, Shuchi

doi:10.1007/s40944-020-00460-1

Cited by 2 publications

(4 citation statements)

References 13 publications

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“…The studies included in the meta-analysis, published from 1985 to 2021, comprised 67,856 women with cervical neoplasia in different stages and 933,697 healthy controls. Of the 35 studies, 11 were conducted in the Western Pacific [ 24 , 28 , 29 , 47 , 48 , 57 , 59 , 62 – 65 ], 9 in Europe and North America [ 27 , 41 – 44 , 46 , 49 , 51 , 52 ], 7 in South America [ 23 , 26 , 50 , 54 , 55 , 66 , 67 ], 4 in South-East Asia [ 22 , 56 , 58 , 60 ], and 4 in the Middle East and Africa [ 25 , 45 , 53 , 61 ]. All of these studies were observational: 20 case-control studies [ 22 , 25 , 41 , 42 , 44 – 51 , 54 , 58 , 61 – 65 , 67 ], 10 cross-sectional studies [ 23 , 24 , 26 – 28 , 55 , 57 , 59 , 60 , …”

Section: Resultsmentioning

confidence: 99%

“…Of the 35 studies, 11 were conducted in the Western Pacific [ 24 , 28 , 29 , 47 , 48 , 57 , 59 , 62 – 65 ], 9 in Europe and North America [ 27 , 41 – 44 , 46 , 49 , 51 , 52 ], 7 in South America [ 23 , 26 , 50 , 54 , 55 , 66 , 67 ], 4 in South-East Asia [ 22 , 56 , 58 , 60 ], and 4 in the Middle East and Africa [ 25 , 45 , 53 , 61 ]. All of these studies were observational: 20 case-control studies [ 22 , 25 , 41 , 42 , 44 – 51 , 54 , 58 , 61 – 65 , 67 ], 10 cross-sectional studies [ 23 , 24 , 26 – 28 , 55 , 57 , 59 , 60 , 66 ], and five cohort studies [ 29 , …”

Section: Resultsmentioning

confidence: 99%

“…All of these studies were observational: 20 case-control studies [ 22 , 25 , 41 , 42 , 44 – 51 , 54 , 58 , 61 – 65 , 67 ], 10 cross-sectional studies [ 23 , 24 , 26 – 28 , 55 , 57 , 59 , 60 , 66 ], and five cohort studies [ 29 , 43 , 52 , 53 , 56 ]. TV infection was assessed by cytology in 13 studies [ 27 , 29 , 43 , 45 , 47 – 49 , 52 , 56 , 58 , 61 , 62 , 67 ], PCR-based methods in nine studies [ 23 , 25 , 26 , 41 , 53 – 55 , 59 , 66 ], microscopy in eight studies [ 22 , 24 , 28 , 42 , 44 , 50 , 60 , 63 ], and other methods (ha...…”

Section: Resultsmentioning

confidence: 99%

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Trichomonas vaginalis infection and risk of cervical neoplasia: A systematic review and meta-analysis

Fazlollahpour-Naghibi

Bagheri

Almukhtar³

et al. 2023

PLoS ONE

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Objectives The evidence in the literature regarding the relationship between Trichomonas vaginalis (TV) infection and cervical neoplasia is conflicting. The main aim of this study was to evaluate the magnitude of the risk of cervical neoplasia associated with TV infection. Methods A meta-analysis of observational studies, which provided raw data on the association of TV infection with cervical neoplasia, was performed. For this aim, we searched scientific databases (PubMed/Medline, Scopus, the Web of Sciences, and Embase) from inception to March 15, 2023. A random-effects model was applied by Stata 17.0 to calculate the pooled and adjusted odds ratios (ORs) with 95% confidence intervals (CI), including subgroup, sensitivity, and cumulative analyses to explore sources of heterogeneity. Results Of the 2584 records initially identified, 35 eligible studies contributed data for 67,856 women with cervical neoplasia, and 933,697 healthy controls from 14 countries were included. The pooled (2.15; 1.61–2.87; I2 = 87.7%) and adjusted (2.17; 1.82–2.60; I2 = 31.27%) ORs indicated a significant positive association between TV infection and the development of cervical neoplasia. There was no significant change in pooled and adjusted ORs by applying sensitivity and cumulative analyses, indicating the robustness of our findings. The pooled OR was significant in most sub-group analyses. There was no publication bias in the included studies. Conclusion Our findings indicated that women with a TV infection are at significantly greater risk of cervical neoplasia. Future research, particularly longitudinal and experimental studies, should be done to better understand the various aspects of this association.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Trichomonas vaginalis infection and risk of cervical neoplasia: A systematic review and meta-analysis

Fazlollahpour-Naghibi

Bagheri

Almukhtar³

et al. 2023

PLoS ONE

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“…Three articles were quantitatively analyzed, with 219 women in the T. vaginalis-positive group and 397 women in the control group. 17,51,58 Women who were T. vaginalis-positive had 5.24 times higher odds of having cervical cancer (OR 5.23, 95% CI 3.03-9.04; I 2 3%; Figure 4) compared with T. vaginalis-negative women.…”

Section: The Association Between T Vaginalis and Cervical Cancermentioning

confidence: 99%

Trichomonas vaginalis infection is associated with increased risk of cervical carcinogenesis: A systematic review and meta‐analysis of 470 000 patients

Hamar

Teutsch

Hoffmann

et al. 2023

Intl J Gynecology & Obste

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BackgroundTrichomonas vaginalis infection is the most prevalent non‐viral sexually transmitted infection (STI) in women and has been suggested as a risk factor for developing cervical cancer.ObjectiveWe aimed to investigate the associations between T. vaginalis infection and cervical carcinogenesis.Search StrategyA comprehensive systematic search was conducted in five databases on 21 October 2021.Selection CriteriaStudies assessing the relationship between T. vaginalis infection, HPV co‐infections, cervical dysplasia, and cervical cancer were found eligible.Data Collection and AnalysisSummary estimates for pooled odds ratios (ORs) and their 95% confidence intervals (CIs) were calculated with a random‐effects model. Statistical heterogeneity was measured with I2 and Cochran's Q tests.Main ResultsThe 29 articles included 473 740 women, of whom 8518 were T. vaginalis‐positive. Our results showed that T. vaginalis‐infected women had 1.79 times higher odds of being diagnosed with HPV co‐infection (95% CI 1.27–2.53; I2 95%). We also found that T. vaginalis infection was associated with high‐grade squamous intraepithelial lesion diagnosis (OR 2.34, 95% CI 1.10–4.95; I2 75%) and cervical cancer (OR 5.23, 95% CI 3.03–9.04; I2 3%).ConclusionsOur results showed an association between T. vaginalis and cervical carcinogenesis in sexually active women.

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Case–Control Study to Find Association of Common RTIs with CIN and Cervical Cancer

Cited by 2 publications

References 13 publications

Trichomonas vaginalis infection and risk of cervical neoplasia: A systematic review and meta-analysis

Trichomonas vaginalis infection and risk of cervical neoplasia: A systematic review and meta-analysis

Trichomonas vaginalis infection is associated with increased risk of cervical carcinogenesis: A systematic review and meta‐analysis of 470 000 patients

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