Case Report: A Case of Chromoblastomycosis Caused by Fonsecaea pedrosoi in Vietnam

Le, Tran-Anh; Nguyen, Khac-Luc; Pham, M B S Catherine; Vi, Thuat-Thang; Do, Ngoc-Anh

doi:10.1007/s11046-018-0284-3

Cited by 6 publications

(4 citation statements)

References 22 publications

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“…pedrosoi in 5, and F . nubica in 1 case [ 165 , 175 , 201 ]. The highest prevalence rates of CBM per 1 million inhabitants were observed in Sri Lanka, Laos, Taiwan, Japan, Malaysia, and Nepal.…”

Section: Resultsmentioning

confidence: 99%

The global burden of chromoblastomycosis

et al. 2021

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Background Chromoblastomycosis (CBM), represents one of the primary implantation mycoses caused by melanized fungi widely found in nature. It is characterized as a Neglected Tropical Disease (NTD) and mainly affects populations living in poverty with significant morbidity, including stigma and discrimination. Methods and findings In order to estimate the global burden of CBM, we retrospectively reviewed the published literature from 1914 to 2020. Over the 106-year period, a total of 7,740 patients with CBM were identified on all continents except Antarctica. Most of the cases were reported from South America (2,619 cases), followed by Africa (1,875 cases), Central America and Mexico (1,628 cases), Asia (1,390 cases), Oceania (168 cases), Europe (35 cases), and USA and Canada (25 cases). We described 4,022 (81.7%) male and 896 (18.3%) female patients, with the median age of 52.5 years. The average time between the onset of the first lesion and CBM diagnosis was 9.2 years (range between 1 month to 50 years). The main sites involved were the lower limbs (56.7%), followed by the upper limbs (19.9%), head and neck (2.9%), and trunk (2.4%). Itching and pain were reported by 21.5% and 11%, respectively. Malignant transformation was described in 22 cases. A total of 3,817 fungal isolates were cultured, being 3,089 (80.9%) Fonsecaea spp., 552 (14.5%) Cladophialophora spp., and 56 Phialophora spp. (1.5%). Conclusions and significance This review represents our current knowledge on the burden of CBM world-wide. The global incidence remains unclear and local epidemiological studies are required to improve these data, especially in Africa, Asia, and Latin America. The recognition of CBM as NTD emphasizes the need for public health efforts to promote support for all local governments interested in developing specific policies and actions for preventing, diagnosing and assisting patients.

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Section: Resultsmentioning

confidence: 99%

The global burden of chromoblastomycosis

et al. 2021

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“…Very few cases of mycetoma and chromoblastomycosis are described in Vietnam and none of sporotrichosis. 55 , 56 …”

Section: Other Fungal Infectionsmentioning

confidence: 99%

Updated estimation of the burden of fungal disease in Vietnam

Beardsley

et al. 2023

Mycoses

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Background Anecdotally, the burden of fungal diseases in Vietnam is rapidly rising, but there has been no updated estimate on this issue since a previous report in 2015. Objectives In this study, we aimed at estimating the incidence and prevalence of serious fungal infections for the year 2020. Methods We made estimates with a previously described methodology, using reports on the incidence and prevalence of various established risk factors for fungal infections from local, regional or global sources. Results We estimated 2,389,661 cases of serious fungal infection occurred in Vietnam in 2020. The most common condition was recurrent vaginal candidiasis (4047/100,000 women annually). Among people living with HIV, we estimated 451 cases of cryptococcal meningitis, 1030 of pneumocystis pneumonia, 166 of histoplasmosis and 1612 of talaromycosis annually. Candidaemia incidence was estimated at 12/100,000 population each year. Owing to its high burden of tuberculosis and respiratory diseases, Vietnam had high rates of severe infections caused by Aspergillus species. Incidence of invasive aspergillosis is 24/100,000 population, allergic bronchopulmonary aspergillosis 78/100,000 and severe asthma with fungal sensitisation 102/100,000. Five‐year period prevalence of chronic pulmonary aspergillosis is 120/100,000 population /5‐year period. Mucormycosis, fungal keratitis and tinea capitis were estimated at 192, 14,431 and 201 episodes each year, respectively. Conclusions The number of patients with mycoses in Vietnam is likely underestimated due to a lack of local data and limited diagnostic capacity, but at least 2.5% of the population might have some form of serious fungal disease.

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“…They are curable and preventable, and can be controlled and even eradicated by implementing the strategies outlined by the Department for the Control of Neglected Tropical Diseases (NTDs) [4].MBC is a chronic, progressive, granulomatous fungal infection of the skin and subcutaneous cellular tissue caused by multiple species of pigmented or pheoid fungi of the family Dematiaceae, which inhabit soil, plants, flowers, and decaying wood [5].The main infectious agents are: Fonsecaea pedrosoi (Negroni, 1936) and Cladophialophora carrionii (Trejos, 1954). This disease has a worldwide distribution and is currently considered a cosmopolitan infection [4,6].In Cuba, the microorganism and the climatic conditions for its development coexist. In addition, there is a high percentage of agricultural and artisanal workers exposed to acquiring this infection.…”

mentioning

confidence: 99%

“…The main infectious agents are: Fonsecaea pedrosoi (Negroni, 1936) and Cladophialophora carrionii (Trejos, 1954). This disease has a worldwide distribution and is currently considered a cosmopolitan infection [4,6].…”

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confidence: 99%

Etiological Diagnosis and Correlation of Chromoblastomycosis with Climatic Variables of Weather Stations in Villa Clara, Cuba

Dianiley García Gómez,

Ricardo Osés Rodríguez,

Daniel Artiles Martínez

et al. 2023

ABJAR

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In Villa Clara province, Cuba, microorganisms and climatic conditions coexist for the development of the infectious entity chromoblastomycosis. Besides, there is a high percentage of agricultural and handicraft workers exposed to acquiring this infection. The objective of the research consisted in describing the etiological diagnosis and correlating chromoblastomycosis with average climatic variables of the meteorological stations located in Villa Clara. Between 2018-2022, a descriptive, cross-sectional study was conducted in a population of 25 patients diagnosed with chromoblastomycosis by anatomopathological and microbiological studies. Absolute frequencies were used as a summary measure, and for correlation with climatic data from the five meteorological stations, inferential statistics. Of the total number of patients, 92% were diagnosed by anatomopathological studies and only 2/8% had mycological studies, in which the species Fonsecaea pedrosoi was isolated. There was a significant correlation between mean temperature (p=0.045) and mean predicted wind (p=0.028) and the number of cases. This was not the case with relative air humidity (p>0.05). It is concluded that in Villa Clara province, only the etiological agent F. pedrosoi was the cause of the disease during the period studied, with a significant relationship between the disease and the average climatic variables mean temperature and mean predicted wind.

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Case Report: A Case of Chromoblastomycosis Caused by Fonsecaea pedrosoi in Vietnam

Abstract: This is the first case of chromoblastomycosis caused by Fonsecaea pedrosoi reported in Vietnam.

Cited by 6 publications

References 22 publications

The global burden of chromoblastomycosis

The global burden of chromoblastomycosis

Updated estimation of the burden of fungal disease in Vietnam

Etiological Diagnosis and Correlation of Chromoblastomycosis with Climatic Variables of Weather Stations in Villa Clara, Cuba

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