Case Report and Genomic Characterization of a Novel Porcine Nodavirus in the United States

Abstract

Nodaviruses are small bisegmented RNA viruses belonging to the family Nodaviridae. Nodaviruses have been identified in different hosts, including insects, fishes, shrimps, prawns, dogs, and bats. A novel porcine nodavirus was first identified in the United States by applying next-generation sequencing on brain tissues of pigs with neurological signs, including uncontrollable shaking. RNA1 of the porcine nodavirus had the highest nucleotide identity (51.1%) to the Flock House virus, whereas its RNA2 shared the highest nucleotide identity (48%) with the RNA2 segment of caninovirus (Canine nodavirus). Genetic characterization classified porcine nodavirus as a new species under the genus Alphanodavirus. Further studies are needed to understand the pathogenicity and clinical impacts of this virus.

Identification and Characterization of Two Novel Noda-like Viruses from Rice Plants Showing the Dwarfing Symptom

“…Nematodes are also known as the hosts of some noda-like viruses that possess unique genome features [18][19][20]. Moreover, some nodaviruses have been found in mammals or their fecal samples [21][22][23][24][25]. Although nodaviruses are currently considered to be animal viruses, some noda-like viruses have also been detected in plant samples through RNA-seq technologies [26,27].…”