Case Report: Boldo (Peumus boldus) and Tacrolimus Interaction in a Renal Transplant Patient

Carbajal, Roger; Yisfalem, A.; Pradhan, N. K.; Baumstein, Donald; Chaudhari, Ashok

doi:10.1016/j.transproceed.2014.01.021

Cited by 14 publications

(6 citation statements)

References 10 publications

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“…Cases of treatment failure or toxicity have been reported in patients consuming tacrolimus, azathioprine and cyclosporine with herbal preparations such as turmeric or chamomile tea [43,50,79,82]. The active phytoconstituents of the herbal medicines inhibit CYP3A4 and P-glycoprotein to reduce elimination of the immunosuppressive agents [96][97][98][99][100].…”

Section: Discussionmentioning

confidence: 99%

Critical evaluation of causality assessment of herb–drug interactions in patients

Awortwe

Makiwane

Reuter

et al. 2018

Brit J Clinical Pharma

114

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The aim of this review was to assess the severity of adverse drug reactions (ADRs) due to herb-drug interactions (HDI) in patients taking herbs and prescribed medications based on published evidence. Electronic databases of PubMed, the Cochrane Library, Medline and Scopus were searched for randomized or nonrandomized clinical studies, case-control and case reports of HDI. The data were extracted and the causal relationship of ADRs as consequences of HDI assessed using Horn's drug interaction probability scale or Roussel Uclaf Causality Assessment Method scoring systems. The mechanism of interaction was ascertained using Stockley's herbal medicine interaction companion. Forty-nine case reports and two observational studies with 15 cases of ADRs were recorded. The majority of the patients were diagnosed with cardiovascular diseases (30.60%), cancer (22.45%) and renal transplants (16.32%) receiving mostly warfarin, alkylating agents and cyclosporine, respectively. HDI occurred in patients resulting in clinical ADRs with different severity. Patients may poorly respond to therapeutic agents or develop toxicity due to severe HDI, which in either scenario may increase the cost of treatment and/or lead to or prolong patient hospitalization. It is warranted to increase patient awareness of the potential interaction between herbs and prescribed medicines and their consequences to curb HDI as a potential health problem.

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Section: Discussionmentioning

confidence: 99%

Critical evaluation of causality assessment of herb–drug interactions in patients

Awortwe

Makiwane

Reuter

et al. 2018

Brit J Clinical Pharma

114

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“…as cholagogue, choleretic, for treatment of mild dyspepsia Carbajal et al (2014) Saponaria officinalis L.…”

Section: Peumus Boldus Molinamentioning

confidence: 99%

Acaricidal properties of extracts of some medicinal and culinary plants against Tetranychus urticae Koch.

Pavela¹

2016

Plant Prot. Sci.

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Pavela R. (2016): Acaricidal properties of extracts of some medicinal and culinary plants against Tetranychus urticae Koch. Plant Protect. Sci., 52: 54-63.The acaricidal activity of aqueous extracts obtained from 28 plant species was tested against Tetranychus urticae. The extract efficacy on the incidence of individual development stages of T. urticae on the treated plants was determined, compared to untreated plants. Of the 28 extracts, 24 showed an efficacy higher than 50%; of these, 16 extracts caused a reduction in the count of adults on the plants by more than 90% compared to the control. The counts of nymphs and eggs showed significant differences depending on the extract used. Only 13 extracts showed an efficacy higher than 50%, and only 2 extracts (obtained from ammi visnaga and Saponaria officinalis) had more than 90% efficacy. Twenty extracts resulted in eggs reduction of more than 50% compared to the control; of these, 6 extracts (from a. visnaga, G. glabra, J. palmata, l. carthamoides, O. majorana, S. officinalis) exhibited an efficacy higher than 90%. Extracts with the highest efficacy were tested for their acute toxicity for T. urticae adults, and LD 50(90) values were estimated. By comparing the confidence intervals (CI 95 ) for individual LD 50 values, extracts obtained from Saponaria officinalis roots and ammi visnaga seeds were found to provide the significantly highest efficacies, and lethal doses (LD 50 ) of 10.3 and 12.5 g/l, respectively, were estimated for them. However, wanting to compare LD 90 values as well, we chose 5 extracts (a. visnaga, C. annum, M. × piperita, O. majorana, and S. officinalis) whose CI 95 intervals overlapped (P ≤ 0.05). Based on our tests, aqueous extracts from S. officinalis roots can be recommended for the development of products which reduce the incidence of T. urticae on plants.

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“…Herb-drug interactions are among the most frequent medical concerns when taking herbs and pharmaceutical prescriptions concurrently (11) . In addition, TAC bioavailability decreased when concurrently administered with St John's wort (SJW), cranberry, rooibos tea, and boldo in human models by induction of CYP450 system isoenzyme and/or P-gp efflux pump (18)(19)(20)(21) . Meanwhile, TAC bioavailability was enhanced in human and/or animal models when grapefruit juice, schisandra, pomelo, and ginger were given concurrently, presumably due to an inhibitory effect on the CYP450 system or the P-gp efflux pump (22)(23)(24) .…”

Section: Discussionmentioning

confidence: 99%

Effect of Curcumin at Various Doses on the Pharmacokinetic Profile of Tacrolimus in Healthy Rabbits

Abushammala

Mqat²,

Hamdan³

2022

IJPS

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The purpose of present study is to evaluate the effect of co-administration of curcumin (CUR) at various doses on the pharmacokinetic (PK) profile of tacrolimus (TAC), a CYP 3A4 substrate in healthy male rabbits. Healthy male rabbits (n=18) were employed in an in vivo, parallel-randomized study. Three groups of rabbits were selected and separated: The rabbits in the first group (control group) received 1 mg/kg TAC orally. Blood samples (1.5-2 mL) were drawn from rabbits' ear marginal veins at the following time frames: 15.0, 30.0, 45.0, 60.0, 90.0, 120.0, 150.0, 180.0 and 300 minutes after TAC administration post dosing and analyzed by using a TAC chemiluminescent enzyme immunoassay (CLIA) detection kit. In the second and third groups (test groups), rabbits received TAC (1mg/kg) at identical conditions as in the control group with volumes equivalent to (30 and 90 mg/kg/day) of prepared CUR suspension in normal saline for seven continuous days. Blood samples from the control group were obtained on the eighth day. Non-compartmental analysis was used to derive different PK parameters of TAC for the three groups. When CUR was co-administered at both concentrations, insignificant statistically small changes between the control and testing groups were found. Our results revealed that the differences for the three groups in PK parameters as Cmax, tmax, ke, AUC0-6 and AUC0-? were statistically insignificant (P>0.05). In conclusion, it has been found that CUR at the experimented doses does not affect the PK of TAC. Further confirmation of our findings is requiered before these results can be applied in patient care.

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Case Report: Boldo (Peumus boldus) and Tacrolimus Interaction in a Renal Transplant Patient

Cited by 14 publications

References 10 publications

Critical evaluation of causality assessment of herb–drug interactions in patients

Critical evaluation of causality assessment of herb–drug interactions in patients

Acaricidal properties of extracts of some medicinal and culinary plants against Tetranychus urticae Koch.

Effect of Curcumin at Various Doses on the Pharmacokinetic Profile of Tacrolimus in Healthy Rabbits

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