“…Since its index study, TopClosure has been successfully used to manage congenital nevi, traumatic hemipelvectomy, bladder extrophy, enteroatmospheric fistula, and extensive abdominal wall defect following malignancy resection. 35,37,40,43,[45][46][47] Topaz has presented numerous studies in the literature reporting on its positive outcomes for managing medium and large soft tissue defects with a low posttreatment complication profile. 35,36,38,47 Supplementing management with oxygen therapy has proven to be effective and may also reduce the risk of anaerobic bacterial contamination and mitigate risk of infection.…”