“…Previous studies have demonstrated the success of combining transdermal laser treatment with the use of sclerosants in the treatment of lower extremity varicose veins. 5 , 6 , 7 , 8 Dinache et al 10 (2020) demonstrated that the laser can interact with the foam, further reducing its microbubbles and increasing its stability, as well as allowing better interface interaction with the tissue. Additionally, external cooling provided by cold air prevented damage to the skin surface.…”