Case Report: Simultaneously Induced Neutropenia and Hemolysis After a Single Metamizole Dose

Abstract

Background and objective Metamizole is a non-opioid ampyrone sulfonate compound with potent analgesic, antipyretic, and spasmolytic effects. Agranulocytosis is a rare life-threatening complication of metamizole. Case Here, we present the case of a 62-year-old patient who developed agranulocytosis as well as hemolysis after a single administration of metamizole. Conclusion This case illustrates the inherent allergic potential of metamizole and its effects on different hematopoietic cell types. Key PointsAgranulocytosis and hemolysis occurred simultaneously as a result of the first and single administration of metamizole.It is unclear which individual factors determine the extent of a potential allergic reaction.Patients receiving metamizole for the first time may benefit from a close follow-up, in particular within the first few weeks.