Case report: Temozolomide induced hypermutation indicates an unfavorable response to immunotherapy in patient with gliomas
Jiapeng Liu,
Shuli Hu,
Haihui Jiang
et al.
Abstract:BackgroundTemozolomide (TMZ) is a key component in the treatment of gliomas. Hypermutation induced by TMZ can be encountered in routine clinical practice, and its significance is progressively gaining recognition. However, the relationship between TMZ-induced hypermutation and the immunologic response remains controversial.Case presentationWe present the case of a 38-year-old male patient who underwent five surgeries for glioma. Initially diagnosed with IDH-mutant astrocytoma (WHO grade 2) during the first two… Show more
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