Caspase-8 dependent apoptosis contributes to dyskinesia caused by muscle defects and neurotoxicity in zebrafish exposed to zearalenone

Wang, Yunpeng; Li, Shuaiting; Cheng, Zhi; Zhang, Ziyuan; Xu, Yu; Zhang, Huan; Xu, Ting; Chen, Jianqiang; Yin, Danyang; Yan, Wenhua; Huang, Huizhe

doi:10.1016/j.fct.2024.114516

Cited by 4 publications

(1 citation statement)

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“… 23 In this study, the increased levels of Methyloligellaceae, Stappiaceae, and norank_o_Chloroplast significantly affected the expression of genes such as Mhc-1 , c3 , Wnt , and caspase 8 ( Figure 6 F), influencing the regulation of immune responses and apoptosis in the liver. 24 , 25 Therefore, the impact of retinoids on gut microbiota can affect liver health through the gut–liver axis. SOD, CAT, T-GSH, LPO, and MDA are key components of antioxidant processes in vertebrates.…”

Section: Discussionmentioning

confidence: 99%

Conversion of Retinoids along the Marine Food Chain Contributes to Adverse Impacts on the Spine, Liver, and Intestinal Health of the Marine Medaka (Oryzias melastigma)

Liu,

Xie,

Xiao

et al. 2024

Environ. Sci. Technol.

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Marine microalgae serve as an aquaculture bait. To enhance algal cell growth and breeding profits, high-intensity light conditions are standard for cultivating bait microalgae, potentially altering microalgal metabolite production. This research revealed that Thalassiosira pseudonana, when subjected to high-intensity light conditions, accumulated significant quantities of retinal (RAL) that transferred through the food chain and transformed into alltrans retinoic acid (atRA) in marine medaka. The study further explored the toxic effects on individual fish and specific tissues, as well as the mechanisms behind this toxicity. The accumulation of atRA in the liver, intestine, and spinal column resulted in structural damage and tissue inflammation, as well as oxidative stress. It also down-regulated the gene transcription levels of key pathways involved in immune function and growth. Furthermore, it disrupted the homeostasis of the intestinal microbial communities. The implications for wildlife and human health, which are influenced by the regulation of microalgal metabolite accumulation and their transfer via the food chain, require further investigation and could hold broader significance.

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Section: Discussionmentioning

confidence: 99%