1999
DOI: 10.1016/s0014-5793(99)00984-9
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Caspases‐3 and ‐7 are activated in goniothalamin‐induced apoptosis in human Jurkat T‐cells

Abstract: Goniothalamin, a plant styrylpyrone derivative isolated from Goniothalamus andersonii, induced apoptosis in Jurkat T-cells as assessed by the externalisation of phosphatidylserine. Immunoblotting showed processing of caspases-3 and -7 with the appearance of their catalytically active large subunits of 17 and 19 kDa, respectively. Activation of these caspases was further evidenced by detection of poly(ADP-ribose) polymerase cleavage (PARP). Pre-treatment with the caspase inhibitor benzyloxycarbonyl-Val-Ala-Asp … Show more

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Cited by 71 publications
(53 citation statements)
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“…These results conducted to other studies investigated the cytotoxic effect of Goniothalamin towards human breast cancer, vascular smooth muscle cells (VSMCs), Jurkat leukemia cells, HL-60 leukemia cells, Chinese hamster ovary (CHO) and hepatoblastoma HepG2 cells (Ali et al, 1997;Pihie et al, 1998;Inayat-Hussain et al, 1999;Inayat-Hussain et al, 2003;Nasir et al, 2004;Chen et al, 2005;Chan et al, 2006;Al-Qubaisi et al, 2011).…”
Section: Discussionmentioning
confidence: 92%
“…These results conducted to other studies investigated the cytotoxic effect of Goniothalamin towards human breast cancer, vascular smooth muscle cells (VSMCs), Jurkat leukemia cells, HL-60 leukemia cells, Chinese hamster ovary (CHO) and hepatoblastoma HepG2 cells (Ali et al, 1997;Pihie et al, 1998;Inayat-Hussain et al, 1999;Inayat-Hussain et al, 2003;Nasir et al, 2004;Chen et al, 2005;Chan et al, 2006;Al-Qubaisi et al, 2011).…”
Section: Discussionmentioning
confidence: 92%
“…These results conducted to other studies investigated the cytotoxic effect of Goniothalamin towards human breast cancer, vascular smooth muscle cells (VSMCs), Jurkat leukemia cells, HL-60 leukemia cells, Chinese hamster ovary (CHO) and hepatoblastoma HepG2 cells (Ali et al, 1997;Pihie et al, 1998;Inayat-Hussain et al, 1999;2003;Chen et al, 2005;2006;Al-Qubaisi et al, 2011).…”
Section: Discussionmentioning
confidence: 94%
“…However, many cancer cells, such as leukemic HL-60 cells, Jurkat T cells, colon HT29 cells were induced to undergo apoptosis by GTN as well (Alabsi et al, 2012;Inayat-Hussain et al, 2003;InayatHussain et al, 2010;Inayat-Hussain et al, 1999). Even though there are reports of mechanisms of cancer cell apoptosis induced by GTN to be mitochondrial pathway, the cross-link between the extrinsic and intrinsic pathways remains elusive.…”
Section: Discussionmentioning
confidence: 99%
“…GTN can also be extracted from several other species of Goniothalamus such as Goniothalamus macrophyllus (Alabsi et al, 2012), Goniothalamus tapisoides Mat Salleh (Kim et al, 2012) and Goniothalamus andersonii (Inayat-Hussain et al, 1999).…”
Section: Introductionmentioning
confidence: 99%
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