2024
DOI: 10.1111/pde.15671
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CASTing the net wider: A case report of PLACK syndrome associated with dilated cardiomyopathy

Cassidy Nguyen,
Connor Hughes,
Samantha Little
et al.

Abstract: PLACK syndrome (OMIM 616295) is a rare genodermatosis associated with peeling skin, leukonychia, acral punctate keratosis, cheilitis, and knuckle pads and is caused by loss‐of‐function mutations in the CAST gene, which encodes calpastatin, a calcium‐dependent protease. This case report highlights a case of PLACK syndrome presenting with the unique findings of striate hyperkeratosis on the palms as well as life‐threatening cardiomyopathy. We review why CAST mutations might impact cardiac function and raise awar… Show more

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