CaT1 Expression Correlates with Tumor Grade in Prostate Cancer

Peng, Ji‐Bin; Zhuang, Liyan; Berger, Urs V.; Adam, Rosalyn M.; Williams, B. Jill; Brown, Edward M.; Hediger, Matthias A.; Freeman, Michael R.

doi:10.1006/bbrc.2001.4638

Cited by 166 publications

(134 citation statements)

References 13 publications

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“…In addition, TRPM8 has originally been cloned from prostate cancer tissue (Tsavaler et al 2001). Moreover, TRPV6 was shown to be strongly upregulated in prostate cancer (Peng et al 2001b;Wissenbach et al 2001Wissenbach et al , 2004. Also in carcinomas of other tissues, such as breast, thyroid, colon and ovary, TRPV6 expression is increased (Zhuang et al 2002).…”

Section: Prostate Cancermentioning

confidence: 99%

“…Peng et al showed that in a human prostate adenocarcinoma cell line TRPV6 mRNA expression was decreased upon dihydrotestosterone treatment, whereas an androgen receptor antagonist significantly increased TRPV6 mRNA levels (Peng et al 2001b). Furthermore, estrogens, also used therapeutically in prostate cancer, positively regulate TRPV6 (van Abel et al 2003).…”

Section: Prostate Cancermentioning

confidence: 99%

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The epithelial calcium channels TRPV5 and TRPV6: regulation and implications for disease

Abel

Hoenderop

Bindels

2005

Naunyn-Schmiedeberg's Arch Pharmacol

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The epithelial Ca 2+ channels TRPV5 and TRPV6 represent a new family of Ca 2+ channels that belongs to the superfamily of transient receptor potential channels. TRPV5 and TRPV6 constitute the apical Ca 2+ entry mechanism in active Ca 2+ transport in kidney and intestine. The central role of TRPV5 and TRPV6 in active Ca 2+ (re)absorption makes it a prime target for regulation to maintain Ca 2+ balance. This review covers the hormonal regulation, interaction with accessory proteins and (patho)physiological implications of these epithelial Ca 2+ channels.

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Section: Prostate Cancermentioning

confidence: 99%

Section: Prostate Cancermentioning

confidence: 99%

The epithelial calcium channels TRPV5 and TRPV6: regulation and implications for disease

Abel

Hoenderop

Bindels

2005

Naunyn-Schmiedeberg's Arch Pharmacol

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“…Nonspecific blockage with ruthenium red, Gd 3+ , and La 3+ was observed (19). TRPV6 mRNA expression is regulated by dietary calcium, 1,25-vitamin D3, dihydrotestosterone, and estrogen (20)(21)(22). The intestinal calcium absorption is significantly reduced in TRPV6 knockout mice (23).…”

Section: Introductionmentioning

confidence: 95%

“…A correlation of TRPV6 expression to the prostate cancer Gleason grade was detected in different cancer stages, whereas there was only little expression in normal prostate tissue (24). Furthermore, certain prostate cancer cell lines such as LNCaP and PC-3 express high amounts of TRPV6 mRNA (20). A study in LNCaP cells showed that TRPV6 can influence the proliferation rate, the cell cycle, and the expression of the proliferating cell nuclear antigen.…”

Section: Introductionmentioning

confidence: 98%

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Tamoxifen Inhibits TRPV6 Activity via Estrogen Receptor–Independent Pathways in TRPV6-Expressing MCF-7 Breast Cancer Cells

Bolanz

Kovács

Landowski

et al. 2009

Molecular Cancer Research

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The epithelial calcium channel TRPV6 is upregulated in breast carcinoma compared with normal mammary gland tissue. The selective estrogen receptor modulator tamoxifen is widely used in breast cancer therapy. Previously, we showed that tamoxifen inhibits calcium uptake in TRPV6-transfected Xenopus oocytes. In this study, we examined the effect of tamoxifen on TRPV6 function and intracellular calcium homeostasis in MCF-7 breast cancer cells transiently transfected with EYFP-C1-TRPV6. TRPV6 activity was measured with fluorescence microscopy using Fura-2. The basal calcium level was higher in transfected cells compared with nontransfected cells in calcium-containing solution but not in nominally calcium-free buffer. Basal influxes of calcium and barium were also increased. In transfected cells, 10 μmol/L tamoxifen reduced the basal intracellular calcium concentration to the basal calcium level of nontransfected cells. Tamoxifen decreased the transport rates of calcium and barium in transfected cells by 50%. This inhibitory effect was not blocked by the estrogen receptor antagonist, ICI 182,720. Similarly, a tamoxifen-induced inhibitory effect was also observed in MDA-MB-231 estrogen receptor-negative cells. The effect of tamoxifen was completely blocked by activation of protein kinase C. Inhibiting protein kinase C with calphostin C decreased TRPV6 activity but did not alter the effect of tamoxifen. These findings illustrate how tamoxifen might be effective in estrogen receptor-negative breast carcinomas and suggest that the therapeutic effect of tamoxifen and protein kinase C inhibitors used in breast cancer therapy might involve TRPV6-mediated calcium entry. This study highlights a possible role of TRPV6 as therapeutic target in breast cancer therapy.

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TRP Channels and Human Diseases

Nilius

Vennekens

2010

Vanilloid Receptor TRPV1 in Drug Discovery

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CaT1 Expression Correlates with Tumor Grade in Prostate Cancer

Cited by 166 publications

References 13 publications

The epithelial calcium channels TRPV5 and TRPV6: regulation and implications for disease

The epithelial calcium channels TRPV5 and TRPV6: regulation and implications for disease

Tamoxifen Inhibits TRPV6 Activity via Estrogen Receptor–Independent Pathways in TRPV6-Expressing MCF-7 Breast Cancer Cells

TRP Channels and Human Diseases

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