Catalase and interleukin-6 serum elevation in a prediction of treatment-resistance in male schizophrenia patients

Yang, Haidong; Zhang, Jing; Yang, Mengqing; Xu, Li; Chen, Wan-Ming; Sun, Yong; Zhang, Xiaobin

doi:10.1016/j.ajp.2022.103400

Cited by 11 publications

(2 citation statements)

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“…In a recent study, no significant association was revealed between CAT concentration and every PANSS subscale score (all P > .05) in patients with chronic schizophrenia (n = 49) ( Yang et al, 2023 ). In another study, CAT concentrations were negatively related with negative symptoms in patients with schizophrenia (n = 96) (Juchnowicz et al, 2019).…”

Section: Discussionmentioning

confidence: 88%

“…Superoxide dismutase (SOD), catalase (CAT), and glutathione (GSH) are 3 first-line endogenous antioxidants ( Pigeolet et al, 1990 ; Liu and Ng, 2000 ; Islam, 2017 ; Ighodaro and Akinloye, 2018 ). Schizophrenia is associated with an alteration of these antioxidants; however, how they affect specific symptoms of the patients remains unclear, with inconsistent and even contradictory findings from previous studies ( Fraguas et al, 2019 ; Ermakov et al, 2021 ; Murray et al, 2021 ) in SOD ( Zhang et al, 2009 ; Wu et al, 2012 ; Gonzalez-Liencres et al, 2014 ; Bai et al, 2018 ; Chien et al, 2020 ; Huo et al, 2021 ), CAT ( Juchnowicz et al, 2021 ; Yang et al, 2023 ), and GSH ( Yao et al, 1999 ; Matsuzawa et al, 2008 ; Chien et al, 2020 ). The previous research about their influences on cognitive functions in schizophrenia has mainly focused on SOD and GSH; however, the results have been inconclusive too ( Gonzalez-Liencres et al, 2014 ; Huo et al, 2021 ).…”

Section: Introductionmentioning

confidence: 94%

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Differential Impacts of Endogenous Antioxidants on Clinical Symptoms and Cognitive Function in Acute and Chronic Schizophrenia Patients

Lin

Huang

et al. 2023

International Journal of Neuropsychopharmacology

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Background Impaired antioxidant defense is implicated in the pathophysiology of schizophrenia; and superoxide dismutase (SOD), catalase (CAT), and glutathione (GSH) are three first-line endogenous antioxidants. Various cognitive functions decline differently during schizophrenia course. The characteristic roles of the three antioxidants in clinical and cognitive profiles in acute and chronic phases of schizophrenia require study. Methods We recruited 311 patients with schizophrenia, including 92 acutely exacerbated patients who had been off antipsychotics for at least 2 weeks and 219 chronic patients who had been stable on medication for at least 2 months. Blood SOD, CAT, and GSH, clinical symptoms, and nine cognitive tests were measured. Results Blood CAT levels were higher in the acute patients than in the chronic patients, while SOD and GSH levels were similar between them. Higher CAT levels were correlated with less positive symptoms, better working memory and problem solving in the acute phase, and less negative symptoms, less general psychopathology, better global assessment of function (GAF), and better cognitive function (in speed of processing, attention, problem solving) in the chronic period. Higher SOD levels were correlated with better GAF in the acute phase, and better speed of processing, working memory, and verbal learning and memory in the chronic period. GSH influenced neither clinical nor cognitive manifestations. Conclusions This study showed that blood CAT affected different clinical and cognitive domains between acute and chronic stages of schizophrenia, SOD influenced cognitive functions in chronic state, but GSH impacted none. Further studies are needed to explore the underlying mechanisms.

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Section: Discussionmentioning

confidence: 88%