Catalpol modulating the crosstalking between mesenchymal stromal cells and macrophages via paracrine to enhance angiogenesis and osteogenesis

Zhang, Yanling; Du, Zhiyun; Li, Dan; Wan, Zhuo; Zheng, Tianyi; Zhang, Xuehui; Yu, Yingjie; Yang, Xiaoping; Cai, Qing

doi:10.1016/j.yexcr.2022.113269

Cited by 8 publications

(3 citation statements)

References 48 publications

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“…CA has many biological activities, including antioxidative, anti‐inflammatory and anti‐ischaemic effects, and exerts protective effects against various diseases, such as osteoporosis and knee osteoarthritis 2,22–24 . In recent studies, catalpol was shown to modulate the physiological functions of MSCs in various ways, including improvement in MSCs survival and myocardial differentiation, enhancement of osteogenic differentiation and promotion of osteogenesis‐angiogenesis coupling 25–29 . However, studies on the impact of active ingredients of medicinal herbs on the recruitment of MSCs and maintaining its chondrogenic phenotypes in cartilage are still limited, and whether CA is effective against cartilage defects remains unknown.…”

Section: Introductionmentioning

confidence: 99%

“… 2 , 22 , 23 , 24 In recent studies, catalpol was shown to modulate the physiological functions of MSCs in various ways, including improvement in MSCs survival and myocardial differentiation, enhancement of osteogenic differentiation and promotion of osteogenesis‐angiogenesis coupling. 25 , 26 , 27 , 28 , 29 However, studies on the impact of active ingredients of medicinal herbs on the recruitment of MSCs and maintaining its chondrogenic phenotypes in cartilage are still limited, and whether CA is effective against cartilage defects remains unknown. Therefore, we conjectured that CA could promote the migration of MSCs to damaged cartilage and stimulate chondrogenesis in an animal model, eventually achieving cartilage repair.…”

Section: Introductionmentioning

confidence: 99%

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Catalpol promotes articular cartilage repair by enhancing the recruitment of endogenous mesenchymal stem cells

Wu,

Shi,

et al. 2024

J Cellular Molecular Medi

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Articular cartilage defect is challenged by insufficient regenerative ability of cartilage. Catalpol (CA), the primary active component of Rehmanniae Radix, could exert protective effects against various diseases. However, the impact of CA on the treatment of articular cartilage injuries is still unclear. In this study, full‐thickness articular cartilage defect was induced in a mouse model via surgery. The animals were intraperitoneally injected with CA for 4 or 8 weeks. According to the results of macroscopic observation, micro‐computed tomography CT (μCT), histological and immunohistochemistry staining, CA treatment could promote mouse cartilage repair, resulting in cartilage regeneration, bone structure improvement and matrix anabolism. Specifically, an increase in the expression of CD90, the marker of mesenchymal stem cells (MSCs), in the cartilage was observed. In addition, we evaluated the migratory and chondrogenic effects of CA on MSCs. Different concentration of CA was added to C3H10 T1/2 cells. The results showed that CA enhanced cell migration and chondrogenesis without affecting proliferation. Collectively, our findings indicate that CA may be effective for the treatment of cartilage defects via stimulation of endogenous MSCs.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Catalpol promotes articular cartilage repair by enhancing the recruitment of endogenous mesenchymal stem cells

Wu,

Shi,

et al. 2024

J Cellular Molecular Medi

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“…The osteogenic potential of BMSCs is the premise of their applications in bone regeneration[ 1 ]. Additionally, the crosstalk between BMSCs and immune cells like macrophages has been recognized as a critical element in achieving ideal bone tissue repair[ 2 ]. Plenty studies have demonstrated that BMSCs are able to trigger a functional switch in macrophages from pro-inflammatory classically activated macrophages (M1) to anti-inflammatory alternatively activated macrophages (M2)[ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Constitutive aryl hydrocarbon receptor facilitates the regenerative potential of mouse bone marrow mesenchymal stromal cells

Huang,

Wang,

Zhou

2023

World J Stem Cells

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The art of constructing an insightful literature review manuscript has witnessed an exemplar in the work of Oz et al (2023), wherein concept progression harmoniously merges with figures and tables. Reflecting on retrospective data science, it is evident that well-cited articles can wield a transformative influence on the Journal Citation Reports Impact Factor score, as exemplified by Robert Weinberg’s landmark on cancer (Hanahan and Weinberg, 2011). Here, we aim to spotlight a commendable contribution by Tuba Oz, Ajeet Kaushik, and Małgorzata Kujawska in this issue while pivoting towards identifying the hallmarks of a subpar literature review-elements that hinder rather than promote advancement. The hurdles and roadblocks encountered within subpar literature reviews are multifold. Anticipation of emerging trends, identification of challenges, and exploration of solutions remain conspicuously absent. Original Contributions fail to surface amidst the vast sea of pre-existing literature, with noticeable gaps amplified by the lack of illustrative figures and tables. The manuscript, at times, assumes a skeletal form, reflecting an attempt to accommodate an excess of references, leading to convoluted sentences laden with citations. In contrast, a potent solution lies in adopting a comprehensive approach. A nuanced and critical evaluation of sources can culminate in a robust discussion, surpassing the mere summarization of conclusions drawn by others. This approach, often dismissed, holds the potential to elevate clarity, coherence, and logical flow, ultimately inviting engaged readership and coveted citations. The critical necessity of integrating visionary insights is underscored and achieved through a rigorous analysis of pivotal concepts and innovative ideas. Examples can be harnessed to elucidate the application of these solutions. We advocate a paradigm shift, urging literature review writers to embrace the readers’ perspective. A literature review’s purpose extends beyond providing a comprehensive panorama; it should illuminate avenues for concept development within a specific field of interest. By achieving this balance, literature reviews stand to captivate a devoted readership, paving the way for manuscripts that are both widely read and frequently cited. The pathway forward requires a fusion of astute analysis and visionary insights, shaping the future of literature review composition.

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Ion‐Engineered Microcryogels via Osteogenesis‐Angiogenesis Coupling and Inflammation Reversing Augment Vascularized Bone Regeneration

Wang,

Pang

et al. 2024

Adv Funct Materials

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Native bone inherently requires a balanced ionic microenvironment to maintain bone homeostasis. Hence, scaffolds designed for the sustained release of therapeutic ions into bone defects hold great promise for bone regeneration. Magnesium (Mg) and silicon (Si) are essential elements, which play crucial roles in the process of bone regeneration, impacting immunomodulation, angiogenesis, and osteogenesis. Herein, porous cryogel‐type organic–inorganic composite microspheres are developed as injectable microscaffolds (denoted as GMN). GMN enables sustained release of Mg/Si ions at an optimized ratio, achieving the most significant synergistic effect on vascularized bone regeneration. Various conditioned media are obtained to explore angiogenesis‐osteogenesis coupling, as well as the crosstalk between bone marrow mesenchymal stromal cells (BMSCs) and macrophages. Meanwhile, autocrine and paracrine effects simultaneously play synergistic modulating functions in determining cell fates under the guidance of Mg/Si ions and biofactors secreted by cells. Overall, the Mg/Si ion‐engineering microscaffolds create a conducive microenvironment to efficiently augment the regeneration of vascularized bone tissue in vivo, offering a versatile platform for tissue engineering.

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Catalpol modulating the crosstalking between mesenchymal stromal cells and macrophages via paracrine to enhance angiogenesis and osteogenesis

Cited by 8 publications

References 48 publications

Catalpol promotes articular cartilage repair by enhancing the recruitment of endogenous mesenchymal stem cells

Catalpol promotes articular cartilage repair by enhancing the recruitment of endogenous mesenchymal stem cells

Constitutive aryl hydrocarbon receptor facilitates the regenerative potential of mouse bone marrow mesenchymal stromal cells

Ion‐Engineered Microcryogels via Osteogenesis‐Angiogenesis Coupling and Inflammation Reversing Augment Vascularized Bone Regeneration

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