Catalyst‐free facile and efficient one‐pot synthesis of densely functionalized pyrroles and α‐amino ketones

Abstract

An efficient catalyst‐free one‐pot three‐component synthesis of penta‐substituted pyrroles has been successfully developed. A variety of penta‐substituted pyrroles were straightforwardly synthesized from good to excellent yields (78%–93%) by using easily accessible starting materials under mild conditions. This protocol also provided α‐amino ketones in good yields (87%–98%) without column chromatography.