CATANA protontherapy facility: The state of art of clinical and dosimetric experience

Cuttone, G.; Cirrone, G.A.P.; Franco, Gabriela; Monaca, Vincenzo; Nigro, S. Ló; Ott, J.; Pittera, S.; Privitera, Giuseppe; Raffaele, L.; Reibaldí, A.; Romano, F.; Sabini, M.G.; Salamone, Vincenzo; Sanfilippo, Matteo; Spatola, Corrado; Valastro, L.

doi:10.1140/epjp/i2011-11065-1

Cited by 48 publications

(35 citation statements)

References 14 publications

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“…A detailed description of the dosimetric procedures adopted at the CATANA irradiation beam line can be found in Ref. [25]. Following the monitor chambers, a 370 mm long brass collimator with an internal diameter of 36 mm is used to limit the beam angular spread.…”

Section: Proton Beam Linementioning

confidence: 99%

Dosimetric characterization of a synthetic single crystal diamond detector in a clinical 62 MeV ocular therapy proton beam

Marinelli¹,

Pompili²,

Prestopino³

et al. 2014

Nuclear Instruments and Methods in Physics Research Section A:

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a b s t r a c tA synthetic single crystal diamond based Schottky photodiode was tested at INFN-LNS on the proton beam line (62 MeV) dedicated to the radiation treatment of ocular disease. The diamond detector response was studied in terms of pre-irradiation dose, linearity with dose and dose rate, and angular dependence. Depth dose curves were measured for the 62 MeV pristine proton beam and for three unmodulated range-shifted proton beams; furthermore, the spread-out Bragg peak was measured for a modulated therapeutic proton beam. Beam parameters, recommended by the ICRU report 78, were evaluated to analyze depth-dose curves from diamond detector. Measured dose distributions were compared with the corresponding dose distributions acquired with reference plane-parallel ionization chambers. Field size dependence of the output factor (dose per monitor unit) in a therapeutic modulated proton beam was measured with the diamond detector over the range of ocular proton therapy collimator diameters (5-30 mm). Output factors measured with the diamond detector were compared to the ones by a Markus ionization chamber, a Scanditronix Hi-p Si stereotactic diode and a radiochromic EBT2 film. Signal stability within 0.5% was demonstrated for the diamond detector with no need of any pre-irradiation dose. Dose and dose rate dependence of the diamond response was measured: deviations from linearity resulted to be within 70.5% over the investigated ranges of 0.5-40.0 Gy and 0.3-30.0 Gy/min respectively. Output factors from diamond detector measured with the smallest collimator (5 mm in diameter) showed a maximum deviation of about 3% with respect to the high resolution radiochromic EBT2 film. Depth-dose curves measured by diamond for unmodulated and modulated beams were in good agreement with those from the reference plane-parallel Markus chamber, with relative differences lower than 7 1% in peak-to-plateau ratios, well within experimental uncertainties. A 2.5% variation in diamond detector response was observed in angular dependence measurements carried-out by varying the proton beam incidence angle in the polar direction. The dosimetric characterization of the tested synthetic single crystal diamond detector clearly indicates its suitability for relative dosimetry in ocular therapy proton beams, with no need of any correction factors accounting for dose rate and linear energy transfer dependence.

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Section: Proton Beam Linementioning

confidence: 99%

Dosimetric characterization of a synthetic single crystal diamond detector in a clinical 62 MeV ocular therapy proton beam

Marinelli¹,

Pompili²,

Prestopino³

et al. 2014

Nuclear Instruments and Methods in Physics Research Section A:

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“…In order to investigate the FC prototype response, an experimental campaign has been performed using the 62 MeV proton beams delivered by the superconducting cyclotron (CS) at the CATANA protontherapy facility [31] at the INFN-LNS (Catania, Italy). A complete characterization of the FC prototype charge measurement varying the bias applied to the suppression electrodes, the proton beam incident current and the dose delivered has been also performed.…”

Section: On-line Beam Diagnostics and Dosimetrymentioning

confidence: 99%

Design and Status of the ELIMED Beam Line for Laser-Driven Ion Beams

et al. 2015

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Charged particle acceleration using ultra-intense and ultra-short laser pulses has gathered a strong interest in the scientific community and it is now one of the most attractive topics in the relativistic laser-plasma interaction research. Indeed, it could represent the future of particle acceleration and open new scenarios in multidisciplinary fields, in particular, medical applications. One of the biggest challenges consists of using, in a future perspective, high intensity laser-target interaction to generate high-energy ions for therapeutic purposes, eventually replacing the old paradigm of acceleration, characterized OPEN ACCESSAppl. Sci. 2015, 5 428 by huge and complex machines. The peculiarities of laser-driven beams led to develop new strategies and advanced techniques for transport, diagnostics and dosimetry of the accelerated particles, due to the wide energy spread, the angular divergence and the extremely intense pulses. In this framework, the realization of the ELIMED (ELI-Beamlines MEDical applications) beamline, developed by INFN-LNS (Catania, Italy) and installed in 2017 as a part of the ELIMAIA beamline at the ELI-Beamlines (Extreme Light Infrastructure Beamlines) facility in Prague, has the aim to investigate the feasibility of using laser-driven ion beams in multidisciplinary applications. ELIMED will represent the first user's open transport beam line where a controlled laser-driven ion beam will be used for multidisciplinary and medical studies. In this paper, an overview of the beamline, with a detailed description of the main transport elements, will be presented. Moreover, a description of the detectors dedicated to diagnostics and dosimetry will be reported, with some preliminary results obtained both with accelerator-driven and laser-driven beams.

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“…Eye melanoma treatments at CATANA use typically 62 MeV proton beams with dose rates that vary from 10 to 20 Gy min −1 (Cuttone et al 2011). Our measurements were performed with monoenergetic passively collimated proton beams of 62 MeV.…”

Section: Experimental Set-upmentioning

confidence: 99%

First full-beam PET acquisitions in proton therapy with a modular dual-head dedicated system

et al. 2013

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During particle therapy irradiation, positron emitters with half-lives ranging from 2 to 20 min are generated from nuclear processes. The half-lives are such that it is possible either to detect the positron signal in the treatment room using an in-beam positron emission tomography (PET) system, right after the irradiation, or to quickly transfer the patient to a close PET/CT scanner. Since the activity distribution is spatially correlated with the dose, it is possible to use PET imaging as an indirect method to assure the quality of the dose delivery. In this work, we present a new dedicated PET system able to operate in-beam. The PET apparatus consists in two 10 cm × 10 cm detector heads. Each detector is composed of four scintillating matrices of 23 × 23 LYSO crystals. The Content from this work may be used under the terms of the Creative Commons Attribution 3.0 licence.

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CATANA protontherapy facility: The state of art of clinical and dosimetric experience

Cited by 48 publications

References 14 publications

Dosimetric characterization of a synthetic single crystal diamond detector in a clinical 62 MeV ocular therapy proton beam

Dosimetric characterization of a synthetic single crystal diamond detector in a clinical 62 MeV ocular therapy proton beam

Design and Status of the ELIMED Beam Line for Laser-Driven Ion Beams

First full-beam PET acquisitions in proton therapy with a modular dual-head dedicated system

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