Cataract morphology and risk for glaucoma after cataract surgery in infants with unilateral congenital cataract

Traboulsi, Elias I.; Freedman, Sharon F.; Wilson, M. Edward; Lambert, Scott R.

doi:10.1016/j.jcrs.2017.10.032

Cited by 6 publications

(5 citation statements)

References 8 publications

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“…Controversy exists over whether the incidence of glaucoma in eyes with PFV after lensectomy is higher than in non-PFV cataracts. Although the Infant Aphakia Treatment Study (IATS) did not show an increased risk of glaucoma or suspect glaucoma in eyes at 5 years after unilateral CCS, 19 other studies reported a higher risk in PFV suggesting underlying factors such as younger age at intervention, associated microphthalmia, microcornea and anterior dysgenesis. 13,21–23 We found no differences in age at CCS between both surgically treated groups, but microcornea was present in 42% and microphthalmia in 83% of the PFV-affected eyes.…”

Section: Discussionmentioning

confidence: 97%

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Outcomes of Ahmed glaucoma valve in paediatric glaucoma following congenital cataract surgery in persistent foetal vasculature

Spiess

Calvo

2020

European Journal of Ophthalmology

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Purpose To evaluate the outcomes of primary Ahmed glaucoma valve in refractory secondary glaucoma following congenital cataract surgery, particularly in persistent foetal vasculature. Method Retrospective review of paediatric patients after Ahmed glaucoma valve implantation for refractory post-lensectomy glaucoma in a tertiary referral centre in Spain. Surgical complications, additional and/or replacements of Ahmed glaucoma valve, intraocular pressure, cup-to-disc ratio, glaucoma medications and final visual acuity were studied. Results A total of 29 eyes, 41% with persistent foetal vasculature and 59% with non–persistent foetal vasculature were included with mean follow-up of 105 ± 67 and 74 ± 45 months, respectively, after first Ahmed glaucoma valve implant. Median survival time for the first Ahmed glaucoma valve was significantly lower in persistent foetal vasculature (7.0 ± 3.2 months) compared to non–persistent foetal vasculature (over 129 months), p = 0.001. The cumulative probability of success in persistent foetal vasculature and non–persistent foetal vasculature eyes with Ahmed glaucoma valve were, respectively, 37.5% and 88.2% at year 1 and 28.1% and 71.9% at year 5. Cox regression model suggested persistent foetal vasculature as predictive risk factor of time to Ahmed glaucoma valve failure (hazard ratio: 5.77, p = 0.004). Four eyes developed phthisis bulbi. Mean intraocular pressure prior glaucoma surgery was 32.66 ± 6.73 mmHg and decreased to 16.54 ± 2.75 mmHg (p < 0.001) at final visit. The most frequent early postoperative complication was severe hypotony (32.6%) which tended to be self-limiting. Vitreous haemorrhage was associated with persistent foetal vasculature (p = 0.024). Ahmed glaucoma valve replacements after complications and additional Ahmed glaucoma valve implantations due to unsatisfactory intraocular pressure were more common in the persistent foetal vasculature group. Conclusion Eyes with persistent foetal vasculature and secondary glaucoma after congenital cataract surgery followed by AGV implantation had a higher number of complications and a decreased probability of success compared to the non-persistent foetal vasculature group. Both groups achieved a significant decrease in intraocular pressure; thus, Ahmed glaucoma valve may be considered as first-line treatment in refractory glaucoma following congenital cataract surgery.

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Section: Discussionmentioning

confidence: 97%

“…Prevalence of glaucoma after PFV-related CCS ranges from 4% to 29% in 1 and 5 years of follow-up, respectively. 18,19…”

Section: Introductionmentioning

confidence: 99%

Outcomes of Ahmed glaucoma valve in paediatric glaucoma following congenital cataract surgery in persistent foetal vasculature

Spiess

Calvo

2020

European Journal of Ophthalmology

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“…El (18) reflejo rojo es una herramienta que se debe realizar a los recién nacidos y que lo puede descartar en forma ´precoz . Cardozo y col en un trabajo realizado en (19) un grupo de pacientes pediátricos encontraron que la frecuencia de catarata congénita de diagnóstico tardío fue de 0.8 % (8).…”

Section: Discussionunclassified

“…(24) El glaucoma también puede desarrollarse después del nacimiento en el glaucoma infantil del desarrollo . (19) Todo niño que presente lagrimeo, fotofobia, opacidad corneal, buftalmos debe llamar la atención del pediatra y descartar glaucoma congénito . (25) En nuestro estudio la conjuntivitis ocupó el tercer lugar entre las patologías oculares.…”

Section: Discussionunclassified

Patologías Oftalmológicas en lactantes menores de 6 meses en un servicio de oftalmopediatría de un hospital de referencia

Sosa,

Cardozo,

Mesquita

2023

Pediatr (Asunción).

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Introducción: Las afecciones oftalmológicas en niños menores de 6 meses pueden producir alteraciones visuales e incluso la ceguera total. Objetivos: Describir la frecuencia y los tipos de patologías oftalmológicas en lactantes menores de 6 meses en un servicio de oftalmopediatría de un hospital infantil. Materiales y Métodos: estudio observacional, descriptivo, retrospectivo. Se revisó la base de datos del servicio de oftalmopediatría. Por muestreo de casos consecutivos fueron incluidos lactantes con edad ≤6 meses, que consultaron en el periodo de marzo a septiembre del 2022, en cuyas fichas figuraban el número telefónico. Variables: edad, sexo, motivo de consulta, antecedentes perinatales y de patologías oftalmológicas, resultado del examen oftalmológico y tratamiento. Los datos fueron analizados en SPSS con estadísticas descriptivas. El comité de ética aprobó el protocolo con consentimiento de los padres. Resultados: Ingresaron 137 lactantes con edad 2,9 ± 1,8 meses, peso de nacimiento 2995 ± 621, edad gestacional 38 ± 2,1 semanas, 53% varones, 31% para control, el 83%, con antecedente de patología ocular. Presentaron patología ocular el 32% (44/137), 59% (26/44) de origen congénito y 41%(18/44) adquiridas. El 18% (8/44) de las alteraciones oculares recibieron tratamiento quirúrgico. Conclusión: El 32% de los lactantes atendidos en el servicio de oftalmopediatria presentaron patologías oculares, de las cuales el 59% fueron congénitas, las dos más frecuentes la catarata congénita y la obstrucción del conducto nasolagrimal.

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“…Not only does such knowledge increase the success of surgery, but it also helps reduce postoperative complications. Characteristic abnormalities may also indicate the difficulties and risks of surgery, which may be helpful in preoperative preparation (7). Thus, an indirect experience that quickly provides professional knowledge and compensates for lack of direct experience is significant.…”

Section: Introductionmentioning

confidence: 99%

Establishing a novel lens opacities classification system based on ultrasound biomicroscopy (UBM) for pediatric cataracts: reliability and availability

Xiang¹,

Jiang²,

Chen³

et al. 2021

Quant Imaging Med Surg

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Background: This study sought to develop and validate a lens opacities classification system based on ultrasound biomicroscopy (UBM) imaging to grade pediatric cataracts. Methods:The study was conducted at Guangzhou Children's Hospital, Guangzhou Women and Children's Medical Center. UBM images of patients at the hospital from September 2013 to November 2014 were used in this study. We summarized the characteristics of lenticular opacification in each of the following 4 zones: the anterior capsule (A); the cortex (C); the nucleus (N); and the posterior capsule (P). The UBM data and intraoperative videos were compared, and sensitivity, specificity, accuracy, and positive and negative predictive values were determined for our Lens Opacities Classification System based on UBM for Pediatric Cataracts (LOCS-UP) detection. Two physicians classified pediatric cataracts (anterior capsule, cortex, and posterior capsule) by extracting 146 images from the UBM database. Patients' data were recorded to calculate the kappa coefficients. The LOCS-UP was developed.Results: Under this standard, all types of pediatric cataracts can be be classified and acquired a code by the LOCS-UP. The LOCS-UP had the highest sensitivity (100%) and specificity (98.96%) in naming the anterior capsule and the lowest sensitivity (50%) and specificity (89.59%) in naming the posterior capsule. Its consistency at naming the anterior capsule was satisfactory (Kappa coefficient: 0.70), and it was also able to name the nucleus, cortex, and posterior capsule (0.56, 0.58, and 0.48, respectively).Conclusions: LOCS-UP could name pediatric cataracts by providing an unique digital encoding, which could reflect characteristics exactly for different local lens anomalies to all kinds of pediatric cataract patients.This method provides detailed and accurate information about patients' lenses.

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Cataract morphology and risk for glaucoma after cataract surgery in infants with unilateral congenital cataract

Cited by 6 publications

References 8 publications

Outcomes of Ahmed glaucoma valve in paediatric glaucoma following congenital cataract surgery in persistent foetal vasculature

Outcomes of Ahmed glaucoma valve in paediatric glaucoma following congenital cataract surgery in persistent foetal vasculature

Patologías Oftalmológicas en lactantes menores de 6 meses en un servicio de oftalmopediatría de un hospital de referencia

Establishing a novel lens opacities classification system based on ultrasound biomicroscopy (UBM) for pediatric cataracts: reliability and availability

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