Catarata e diabetes mellitus tipo 1

Pizzol, Melissa Manfroi Dal; Esteves, J; Sccoco, Caio Augusto; Roggia, Murilo Felix; Rosa, Carolina Maurente da; Lambert, José Humberto Franco; Canani, Luís Henrique Santos

doi:10.1590/s0004-27492008000400018

Cited by 6 publications

(3 citation statements)

References 12 publications

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“…Hence, the higher prevalence of cataracts in our patients was expected. Dal Pizzol et al 30 observed 20% prevalence of cataracts among persons with diabetes in Brazil. A multicenter study in West African countries suggested 17.9% and 44.9% prevalence of DR and cataracts, respectively, in patients with type 2 diabetes.…”

Section: Dr In Western Indiamentioning

confidence: 98%

Magnitude and Determinants of Ocular Morbidities Among Persons with Diabetes in a Project in Ahmedabad, India

Vyas

Khandekar²,

Trivedi

et al. 2009

Diabetes Technology & Therapeutics

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Section: Dr In Western Indiamentioning

confidence: 98%

Magnitude and Determinants of Ocular Morbidities Among Persons with Diabetes in a Project in Ahmedabad, India

Vyas

Khandekar²,

Trivedi

et al. 2009

Diabetes Technology & Therapeutics

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“…Pizzol et al 22 Hiperglicemia crônica é um dos fatores responsáveis por modificações em proteínas cristalinas.…”

Section: Autor Principais Achadosunclassified

Diabetes melito: hiperglicemia crônica e suas complicações

Ferreira

Saviolli

Valenti

et al. 2011

Arq. Bras. Ciên. Saúde

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ResumoIntrodução: O termo diabetes melito descreve uma desordem metabólica de múltipla etiologia, caracterizado por hiperglicemia crônica decorrente de defeitos na secreção e/ou ação da insulina. O diabetes melito é classificado em tipo 1 e 2, diabetes gestacional e outros tipos. A hiperglicemia crônica é o fator primário desencadeador das complicações do diabetes melito. Objetivo: Descrever os mecanismos fisiopatológicos das complicações crônicas e dos distúrbios metabólicos decorrentes da hiperglicemia. Métodos: Foram consultadas as bases de dados do SciELO, Lilacs e Medline. As consultas incluíram artigos registrados entre 1999 e 2010, nas línguas portuguesa e inglesa. Resultados: A hiperglicemia promove a formação dos produtos de glicação avançada (AGEs), responsáveis por complicações macrovasculares. A insulinopenia estimula a secreção de hormônios contrainsulínicos como glucagon, cortisol, catecolaminas e hormônio do crescimento. Iniciam-se processos catabólicos (lipólise e proteólise). Ácidos graxos são captados pelas células hepáticas. Ocorre síntese de acetil-Coa que é convertida em corpos cetônicos. A retenção de corpos cetônicos no plasma provoca acidose metabólica. Alterações na fisiologia ocular são derivadas da opacificação do cristalino e de modificações vasculares retinianas. Nefropatia diabética é a complicação crônica microvascular que compromete a função renal por aumento da membrana basal glomerular. A neuropatia diabética envolve a ativação da via do poliol, a síntese de AGEs e a redução do fluxo sanguíneo neural. Conclusão: A patogênese das alterações fisiológicas e metabólicas decorrentes da hiperglicemia compreende mecanismos fisiológicos, biológicos e bioquímicos que afetam a qualidade de vida do organismo.Palavras-chave: diabetes mellitus; hiperglicemia; complicações do diabetes; cetoacidose diabética. AbstractIntroduction: The term diabetes mellitus describes a metabolic disorder of multiple etiology, which is characterized by chronic hyperglycemia resulting from

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“…It is believed that the risk of eye diseases such as retinopathy and diabetic cataract (DC) increases with the pathogenesis of diabetes. DC is a serious disease because approximately 20% of diabetic patients develop DC (2), and cataracts account for a majority of the visual impairment cases globally (3). As lens proteins are known to be only slightly metabolized during the lifetime, cataracts are difficult to reverse once they have progressed.…”

mentioning

confidence: 99%

<i>Aphanothece sacrum</i> (Sur.) Okada Prevents Cataractogenesis in Type 1 Diabetic Mice

Matsuda

Sugawa

Shirakawa

et al. 2017

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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Summary Aphanothece sacrum (Sur.) Okada is a species of cyanobacteria found in Japan. Although it has been used in local cuisine in Kyushu, Japan, for 250 y, little is known about its beneficial effect as food. The daily intake of health beneficial phytochemicals is believed to be useful for preventing lifestyle-related diseases, such as diabetic cataracts. In this study, the inhibitory effect of freeze-dried A. sacrum (Asa) on the formation of diabetic cataracts (DCs) was evaluated. Type 1 diabetes was induced in mice using streptozotocin (STZ). The mice were divided into two groups: one was fed a normal diet (DM-control group) and the other was fed a diet containing 1% Asa (DM-Asa group). During the study, changes in blood glucose levels and the amount of food and water consumed were measured. After 3 mo, the amount of N ε -(carboxymethyl)lysine (CML), an oxidative stress marker, in the lens was measured using liquid chromatography-tandem mass spectrometry (LC-MS/MS). Although the blood glucose levels (pϭ0.91) and food consumption did not significantly change in any group, the oral administration of Asa tended to suppress CML accumulation (pϭ0.15) and significantly inhibited the progression of cataractogenesis in the diabetic lens compared with that reported for the normal diet (pϭ0.009). These results suggested that the daily intake of A. sacrum prevents the pathogenesis of cataracts, and indicated that may reduce the number of DC patients.

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Catarata e diabetes mellitus tipo 1

Cited by 6 publications

References 12 publications

Magnitude and Determinants of Ocular Morbidities Among Persons with Diabetes in a Project in Ahmedabad, India

Magnitude and Determinants of Ocular Morbidities Among Persons with Diabetes in a Project in Ahmedabad, India

Diabetes melito: hiperglicemia crônica e suas complicações

<i>Aphanothece sacrum</i> (Sur.) Okada Prevents Cataractogenesis in Type 1 Diabetic Mice

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