Catastrophic deterioration in asthma induced by rifampicin in steroid-dependent asthma

Udwadia, Zarir; Sridhar, Ganga; Beveridge, C.J.; Soutar, C. A.; McHardy, G. J. R.; Leitch, A. G.

doi:10.1016/s0954-6111(05)80267-7

Cited by 11 publications

(2 citation statements)

References 3 publications

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“…Other case reports of harm occurring due to loss of steroid efficacy with rifampin range in diseases such as nephrotic syndrome, giant cell arteritis, immunosuppression for renal transplant, and asthma [ 47 – 50 ]. A pharmacokinetic study of two patients with giant cell arteritis treated with prednisone and rifampin found that prednisolone clearance increased by greater than 200% and half-life decreased by 40% to 60% compared to prednisolone administration without rifampin.…”

Section: Anti-fungal Agentsmentioning

confidence: 99%

Pharmacokinetic Drug–Drug Interactions Between Immunosuppressant and Anti-Infective Agents: Antimetabolites and Corticosteroids

Matre

Satyanarayana²,

Page

et al. 2018

Ann Transplant

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Infections account for 15–20% of deaths in transplant recipients, requiring rapid and appropriate therapeutic interventions. Many anti-infective agents interact with immunosuppressive regimens used in transplantation, placing patients at increased risk for adverse drug reactions and prolonged hospitalizations. There is established data regarding the level of evidence and magnitude of interactions between calcineurin inhibitors and mammalian target of rapamycin inhibitors with anti-infective agents. Less is known about the interactions with anti-proliferative agents and corticosteroids, with gaps in knowledge on the appropriate management of these interactions. The objective of this review was to highlight the pharmacokinetic drug–drug interactions between antimetabolites and corticosteroids with commonly used anti-infective agents.

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Section: Anti-fungal Agentsmentioning

confidence: 99%

Pharmacokinetic Drug–Drug Interactions Between Immunosuppressant and Anti-Infective Agents: Antimetabolites and Corticosteroids

Matre

Satyanarayana²,

Page

et al. 2018

Ann Transplant

View full text Add to dashboard Cite

show abstract

“…[33][34][35] Similarly, disease states such as hyperthyroidism can induce accelerated glucocorticoid metabolism,l36] These abnormalities can be evaluated by pharmacokinetic studies of glucocorticoids, involving serial determinations of serum drug concentration. [29] Unfortunately, these investigations are currently available only in research centres.…”

Section: Pharmacological Factorsmentioning

confidence: 99%